Hypothalamic gene switches control transitions between seasonal life history states in a night-migratory photoperiodic songbird

MOLECULAR AND CELLULAR ENDOCRINOLOGY

卷:399

Article

Majumdar, Gaurav¹  Rani, Sangeeta²  Kumar, Vinod¹ 

[1] Univ Delhi, DST IRHPA, Ctr Excellence Biol Rhythms Res, Dept Zool, Delhi 110007, India

[2] Univ Lucknow, DST IRHPA, Ctr Excellence Biol Rhythms Res, Dept Zool, Lucknow 226007, Uttar Pradesh, India

关键词: Bunting;    Critical day length;    Circadian;    Genes;    Metabolism;    Opsins;   

DOI  :  10.1016/j.mce.2014.09.020

来源: Elsevier

【 摘 要 】

This study investigated photoperiodic plasticity in hypothalamic expression of genes implicated in the photoperiodic light perception (rhodopsin, melanopsin, neuropsin and peropsin), transduction (pax6, bmal1, clock, per2 and casr), induction (eya3, tsh beta, dio2 and dio3, gnrh and gnih) and metabolism (NPY, sirtuin1, foxO1, hmgcr, citrate synthase and dehydrogenases) in photosensitive and photorefractory redheaded buntings. There was a significant increase in eya3, tsh beta, dio2, pax6 and rhodopsin and decrease in dio3 mRNA expression at hour 15 and/or 19 on the day photosensitive buntings were subjected to a 13- or 16 h, but not to 8- and 11 h light exposure. Downstream reproductive and metabolic gene expression was not altered, except for an increase in those genes coding for succinate and malate dehydrogenase enzymes involved in lipogenesis. Photorefractory buntings had high dio3 mRNA expression which significantly declined after 1 short day exposure, suggesting possible involvement of dio3 in the maintenance of photorefractoriness. Positive correlation of rhodopsin on eya 3 and tsh beta indicates its role in photoperiodic timing, perhaps involving the peropsin and pax6 genes. These results suggest that rapid switching of hypothalamic gene expression underlies photoperiod-induced seasonal plasticity and regulates transitions from photosensitive to photostimulated and from photorefractory to photosensitive states in migratory songbirds. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

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