Orexins (hypocretins) and energy balance: More than feeding

MOLECULAR AND CELLULAR ENDOCRINOLOGY

卷:418

Article

Ferno, Johan^1,2  Senaris, Rosa¹  Dieguez, Carlos^1,3  Tena-Sempere, Manuel^3,4,5  Lopez, Miguel^1,3 

[1] Univ Santiago de Compostela, CIMUS, Dept Physiol, Inst Invest Sanitaria, Santiago De Compostela 15782, Spain

[2] Univ Bergen, Dept Clin Sci, KG Jebsen Ctr Diabet Res, N-5021 Bergen, Norway

[3] CIBER Fisiopatol Obesidad & Nutr CIBERobn, Madrid 15706, Spain

[4] Univ Cordoba, Dept Cell Biol Physiol & Immunol, Inst Maimonides Invest Biomed IMIBIC, Hosp Reina Sofia, E-14004 Cordoba, Spain

[5] Univ Turku, Dept Physiol, FiDiPro Program, FIN-20520 Turku, Finland

关键词: Orexins;    Energy balance;    Hypothalamus;    Food intake;    Brown adipose tissue;   

DOI  :  10.1016/j.mce.2015.07.022

来源: Elsevier

【 摘 要 】

Initially implicated in the regulation of feeding, orexins/hypocretins are now acknowledged to play a major role in the control of a wide variety of biological processes, such as sleep, energy expenditure, pain, cardiovascular function and neuroendocrine regulation, a feature that makes them one of the most pleiotropic families of hypothalamic neuropeptides. While the orexigenic effect of orexins is well described, their central effects on energy expenditure and particularly on brown adipose tissue (BAT) thermogenesis are not totally unraveled. Better understanding of these actions and their possible interrelationship with other hypothalamic systems controlling thermogenesis, such as AMP-activated protein kinase (AMPK) and endoplasmic reticulum (ER) stress, will help to clarify the exact role and pathophysiological relevance of these neuropeptides have on energy balance. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

Free