The Wnt/beta-catenin pathway in adrenocortical development and cancer

MOLECULAR AND CELLULAR ENDOCRINOLOGY

卷:332

Review

El Wakil, Abeer^1,2,3  Lalli, Enzo^1,2 

[1] CNRS, Inst Pharmacol Mol & Cellulaire, UMR 6097, F-06560 Valbonne, France

[2] Univ Nice Sophia Antipolis, Valbonne, France

[3] Univ Alexandria, Dept Biol Sci, Fac Educ, Alexandria, Egypt

关键词: Adrenal cortex;    Wnt;    beta-Catenin;    Development;    Cancer;   

DOI  :  10.1016/j.mce.2010.11.014

来源: Elsevier

【 摘 要 】

Signaling by the Wnt family of secreted glycolipoproteins plays key roles in embryonic development of organisms ranging from nematodes to mammals and is also implicated in several types of human cancers. Canonical Wnt signaling functions by regulating the translocation of beta-catenin to the nucleus, where it controls key gene expression programs through interaction with Tcf/Lef and other families of transcription factors. Wnts can also act through non-canonical pathways that do not involve beta-catenin activation, but implicate small GTPases/JNK kinase and intracellular calcium. Here we review recent studies that have revealed the expression of several components of Wnt/beta-catenin signaling in the adrenal cortex and discovered a key role for this pathway in the regulation of proliferation/differentiation of progenitor cells and in tumorigenesis of that endocrine organ. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

Free