MicroRNAs relate to early worsening of renal function in patients with acute heart failure

INTERNATIONAL JOURNAL OF CARDIOLOGY

卷:203

Article

Bruno, Noemi¹  ter Maaten, Jozine M.¹  Ovchinnikova, Ekaterina S.²  Vegter, Eline L.¹  Valente, Mattia A. E.¹  van der Meer, Peter¹  de Boer, Rudolf A.¹  van der Harst, Pim¹  Schmitter, Daniela³  Metra, Marco⁴  O'Connor, Christopher M.⁵  Ponikowski, Piotr⁶  Teerlink, John R.⁷  Cotter, Gad⁸  Davison, Beth⁸  Cleland, John G.^9,10  Givertz, Michael M.¹¹  Bloomfield, Daniel M.¹²  Dittrich, Howard C.¹³  Pinto, Yigal M.¹⁴  van Veldhuisen, Dirk J.¹  Hillege, Hans L.¹  Berezikov, Eugene²  Voors, Adriaan A.¹ 

[1] Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands

[2] Univ Groningen, Univ Med Ctr Groningen, European Res Inst Biol Ageing, Groningen, Netherlands

[3] Momentum Res Inc, Allschwil, Switzerland

[4] Univ Brescia, Dept Cardiol, Brescia, Italy

[5] Duke Univ, Med Ctr, Duke Clin Res Inst, Durham, NC USA

[6] Med Univ, Clin Mil Hosp, Wroclaw, Poland

[7] Univ Calif San Francisco, San Francisco Vet Affairs Med Ctr, San Francisco, CA 94143 USA

[8] Momentum Res, Durham, NC USA

[9] Univ London Imperial Coll Sci Technol & Med, Royal Brompton Hosp, Natl Heart & Lung Inst, London, England

[10] Univ London Imperial Coll Sci Technol & Med, Harefield Hosp, Natl Heart & Lung Inst, London, England

[11] Harvard Univ, Brigham & Womens Hosp, Sch Med, Boston, MA 02115 USA

[12] Merck Res Labs, Rahway, NJ USA

[13] Univ Iowa, Carver Coll Med, Cardiovasc Res Ctr, Iowa City, IA USA

[14] Univ Amsterdam, Amsterdam, Netherlands

关键词: Circulating microRNA;    Acute heart failure;    Worsening renal function;   

DOI  :  10.1016/j.ijcard.2015.10.217

来源: Elsevier

【 摘 要 】

Background: Deregulation of microRNAs (miRNAs) may be involved in the pathogenesis of heart failure (HF) and renal disease. Our aim is to describe miRNA levels related to early worsening renal function in acute HF patients. Method and results: We studied the association between 12 circulating miRNAs and Worsening Renal Function (WRF; defined as an increase in the serum creatinine level of 0.3 mg per deciliter or more from admission to day 3), absolute change in creatinine and Neutrophil Gelatinase Associated Lipocalin (NGAL) from admission to day 3 in 98 patients hospitalized for acute HF. At baseline, circulating levels of all miRNAs were lower in patients with WRF, with statistically significant decreased levels of miR-199a-3p, miR-423-3p, and miR-let-7i-5p (p-value < 0.05). The increase in creatinine during the first 3 days of hospitalization was significantly associated with lower levels of miR-199a-3p, miR-27a-3p, miR-652-3p, miR-423-5p, and miR-let-7i-5p, while the increase in NGAL was significantly associated with lower levels of miR-18a-5p, miR-106a-5p, miR-223-3p, miR-199a-3p and miR-423-3p. MiR-199a-3p was the strongest predictor of WRF, with an Odds Ratio of 1.48 (1.061-2.065; p-value = 0.021) and a C-index of 0.701. Conclusions: Our results show that the levels of circulating miRNAs at hospital admission for acute HF were consistently lower in patients who developed worsening of renal function. MiR-199a-3p was the best predictor of WRF in these patients. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

Free