Significance of the CAPRI risk score to predict heart failure hospitalization post-TAVI: The CAPRI-HF study

INTERNATIONAL JOURNAL OF CARDIOLOGY

卷:296

Article

Harbaoui, Brahim^1,2,3  Durand, Eric⁴  Dupre, Marion⁴  Rabilloud, Muriel⁵  Souteyrand, Geraud⁶  Courand, Pierre-Yves^1,2,3  Boussel, Loic^3,7  Lefevre, Thierry⁸  Eltchaninoff, Helene⁴  Lantelme, Pierre^1,2,3 

[1] Hop Croix Rousse, Cardiol Dept, 103 Grande Rue Croix Rousse, F-69004 Lyon, France

[2] Hosp Civils Lyon, Hop Lyon Sud, Lyon, France

[3] Univ Lyon, CREATIS, INSERM, U1044,UMR5220,INSA 15, Lyon, France

[4] Rouene Charles Nicolle Univ Hosp Ctr, Natl Inst Hlth & Med Res, Cardiol Serv, U644, Rouen, France

[5] Univ Lyon, Serv Biostat & Bioinformat, Lab Biometrie & Biol Evolut, CNRS,UMR 5558,Equipe Biostat Sante, F-69100 Villeurbanne, France

[6] Univ Auvergne, Gabriel Montpied Univ Hosp Ctr, Image Sci Intervent Tech Cardiovasc Intervent The, Natl Sci Res Ctr,UMR 6284,Dept Cardiol, Clermont Ferrand, France

[7] Hosp Civils Lyon, Hop Croix Rousse, Radiol Dept, Lyon, France

[8] Inst Cardiovasc Paris Sud, Ramsay Gen De Sante, France

关键词: TAVR;    Outcome;    Hospitalization;    Risk score;    Heart failure;    Aortic stiffness;   

DOI  :  10.1016/j.ijcard.2019.08.033

来源: Elsevier

【 摘 要 】

Background: Predictors of heart failure (HF) hospitalization after transcatheter aortic valve implantation (TAVI) are not well defined. CAPRI is a score for predicting 1-year post-TAVI cardiovascular and all-cause mortality. The aim of the present study is to assess the prognostic significance of the CAPRI score for HF hospitalization 1 year after TAVI. Methods and results: CAPRI-HF is an ancillary study of the C4CAPRI trial, analyzing 409 consecutive patients treated by TAVI. The primary outcome was hospitalization for HF during the first year post-intervention. The prognostic value of the CAPRI score was assessed by multivariable analysis adjusted for diabetes, atrial fibrillation, vascular route, pacemaker implantation, post-TAVI aortic regurgitation, transfusion and pulmonary artery systolic pressure. A subanalysis focused on patients with low-gradient aortic stenosis (LGAS). At 1 year, HF hospitalization occurred in 78 (19.9%) patients. Patients with HF were more prone to have diabetes, atrial fibrillation, renal dysfunction, lower mean aortic gradient, higher logistic EuroSCORE and higher CAPRI score (p < .05 for all associations). In the multivariable analysis, CAPRI score was the sole predictor of HF: hazard ratio (HR) for each 0.1 CAPRI score increase was 1.065, 95% confidence interval (CI) 1.021-1.110. This was confirmed when adjusted for EuroSCORE: HR 1.066, 95% CI 1.024-1.110. The predictive power of the CAPRI score increased for LGAS: HR 1.098, 95% CI 1.028-1.172. Conclusions: CAPRI score helps predictHF post-TAVI. Including the score in the decision-making process may help selecting candidates for TAVI and identifying patients who need close monitoring post-procedure. (C) 2019 Elsevier B.V. All rights reserved.

【 授权许可】

Free