Does total volume of physical activity matter more than pattern for onset of CVD? A prospective cohort study of older British men

INTERNATIONAL JOURNAL OF CARDIOLOGY

卷:278

Article

Jefferis, Barbara J.¹  Parsons, Tessa J.¹  Sartini, Claudio¹  Ash, Sarah¹  Lennon, Lucy T.¹  Papacosta, Olia¹  Morris, Richard W.²  Wannamethee, S. Goya¹  Lee, I-Min³  Whincup, Peter H.⁴ 

[1] UCL, Dept Primary Care & Populat Hlth, Rowland Hill St, London NW3 2PF, England

[2] Univ Bristol, Populat Hlth Sci, Bristol Med Sch, Canynge Hall 39 Whatley Rd, Bristol BS8 2PS, Avon, England

[3] Harvard Med Sch, Brigham & Womens Hosp, 900 Commonwealth Ave East, Boston, MA 02215 USA

[4] St Georges Univ London, Populat Hlth Res Inst, Cranmer Terrace, London SW17 0RE, England

关键词: Physical activity;    Sedentary behaviour;    Accelerometer;    CHD;    Stroke;    Heart failure;   

DOI  :  10.1016/j.ijcard.2018.12.024

来源: Elsevier

【 摘 要 】

Aims: With increasing age, physical inactivity and sedentary behaviour levels increase, as does cardiovascular disease (CVD) incidence. We investigate how device-measured sedentary behaviour and physical activity (PA) are related to CVD onset in men aged 70+; whether the total volume of activity is more important than pattern. Methods and results: Prospective population-based cohort study of men recruited from24 UK General Practices in 1978-80. In 2010-12, 3137 survivors were invited to complete questionnaires and wear an Actigraph GT3x accelerometer for 7 days. PA intensity was categorised as sedentary, light and moderate to vigorous (MVPA). Men were followed up for Myocardial Infarction, stroke and heart failure (ICD9 410-414, 430-438 and 428) morbidity and mortality from 2010 to 12 to June 2016. Hazard Ratios (HRs) for incident Cardiovascular Disease (CVD) were estimated. 1528/3137 (49%) men had sufficient accelerometer data. 254 men with pre-existing CVD were excluded. Participants' mean age was 78.4 (range 71-92) years. After median 4.9 years follow-up, 122 first CVD events occurred in 1181 men (22.7/1000 person-years) with complete data. For each additional 30 min in sedentary behaviour, light PA, 10 min in MVPA, or 1000 steps/day, HRs for CVD were 1.09(95% CI 1.00, 1.19), 0.94(0.85, 1.04), 0.88(0.81, 0.96) and 0.86(0.78 to 0.95) respectively, adjusted for measurement-related factors, socio-demographics, health behaviours and disability. HRs for accumulating 150 min/week MVPA in bouts >= 1 min and bouts >= 10 min were 0.47(0.32 to 0.69), and 0.49(0.25, 0.98). Conclusions: In older men, high volume of steps or MVPA rather than MVPA bouts was associated with reduced CVD risk. (c) 2018 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

【 授权许可】

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