Healthy diet reduces markers of cardiac injury and inflammation regardless of macronutrients: Results from the OmniHeart trial

INTERNATIONAL JOURNAL OF CARDIOLOGY

卷:299

Article

Kovell, Lara C.¹  Yeung, Edwina H.²  Miller, Edgar R., III³  Appel, Lawrence J.³  Christenson, RobertH.⁴  Rebuck, Heather⁴  Schulman, Steven P.⁵  Juraschek, Stephen P.⁶ 

[1] Univ Massachusetts, Med Sch, Div Cardiol, Worcester, MA USA

[2] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Epidemiol Branch, Div Intramural Populat Hlth Res, NIH, Bethesda, MD USA

[3] Johns Hopkins Univ, Welch Ctr Prevent Epidemiol & Clin Res, Baltimore, MD USA

[4] Univ Maryland, Sch Med, Dept Pathol, Baltimore, MD 21201 USA

[5] Johns Hopkins Univ, Sch Med, Dept Med, Div Cardiol, Baltimore, MD 21205 USA

[6] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Boston, MA 02115 USA

关键词: Diet;    Randomized trial;    High-sensitivity cardiac troponin I;    High-sensitivity C-reactive protein;    Cardiovascular risk factors;    Hypertension;   

DOI  :  10.1016/j.ijcard.2019.07.102

来源: Elsevier

【 摘 要 】

Background: Despite diet being a first-line strategy for preventing cardiovascular disease, the optimal macronutrient profile remains unclear. We studied the effects of macronutrient profile on subclinical cardiovascular injury and inflammation. Methods: OmniHeart was a randomized 3-period, crossover feeding study in 164 adults with high blood pressure or hypertension (SBP 120-159 or DBP 80-99 mm Hg). Participants were fed each of 3 diets (emphasizing carbohydrate (CARB), protein (PROT), or unsaturated fat (UNSAT)) for 6-weeks, with feeding periods separated by a washout period. Weight was held constant. Fasting serum was collected at baseline while participants ate their own diets and after each feeding period. High-sensitivity cardiac troponin I (hs-cTnI) and high-sensitivity C-reactive protein (hs-CRP) were measured in stored specimens. Results: The average age was 53.6 years, 55% were African American, and 45% were women. At baseline, the median (25th-percentile, 75th-percentile) hs-cTnI was 3.3 ng/L (1.9, 5.6) and hs-CRP was 2.2 mg/L (1.1, 5.2). Compared to baseline, all 3 diets reduced hs-cTnI: CARB -8.6% (95%CI: -16.1, -0.4), PROT -10.8% (-18.4, -2.5), and UNSAT -9.4% (-17.4, -0.5). Hs-CRP was similarly changed by -13.9 to -17.0%. Hs-cTnI and hs-CRP reductions were of similar magnitudes as SBP and low-density lipoprotein cholesterol (LDLc) but were not associated with these risk-factor reductions (P-values = 0.09). There were no between-diet differences in hs-cTnI and hs-CRP reductions. Conclusions: Healthy diet, regardless of macronutrient emphasis, directly mitigated subclinical cardiac injury and inflammation in a population at risk for cardiovascular disease. These findings support dietary recommendations emphasizing healthy foods rather than any one macronutrient. (C) 2019 Elsevier B.V. All rights reserved.

【 授权许可】

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