Healthy lifestyle factors and incident heart disease and mortality in candidates for primary prevention with statin therapy

INTERNATIONAL JOURNAL OF CARDIOLOGY

卷:207

Article

Booth, John N., III¹  Colantonio, Lisandro D.¹  Howard, George¹  Safford, Monika M.¹  Banach, Maciej²  Reynolds, Kristi³  Cushman, Mary⁴  Muntner, Paul¹ 

[1] Univ Alabama Birmingham, Birmingham, AL 35294 USA

[2] Med Univ Lodz, Lodz, Poland

[3] Kaiser Permanente So Calif, Pasadena, CA 91101 USA

[4] Univ Vermont, Colchester, VT USA

关键词: Healthy lifestyle;    Statins;    Atherosclerotic cardiovascular disease;    Cholesterol treatment guidelines;    Atherosclerotic cardiovascular disease risk;    Mortality;   

DOI  :  10.1016/j.ijcard.2016.01.001

来源: Elsevier

【 摘 要 】

Background: There are limited data on the use of healthy lifestyles among adults who are candidates for primary prevention of atherosclerotic cardiovascular disease (ASCVD) with statin therapy due to a 10-year predicted risk >= 7.5%. We determined the prevalence of healthy lifestyle factors and their association with incident ASCVD and all-cause mortality in the Reason for Geographic and Racial Differences in Stroke study participants (n = 5709). Methods: Lifestyle factors (non-obese waist circumference, physical activity >= 5 times-per-week, non-smoking, low saturated-fat-intake, highest Mediterranean diet score quartile) were assessed during an in-home examination and interviewer-administered questionnaires. Adjudicated incident ASCVD (nonfatal/fatal stroke, nonfatal myocardial infarction or coronary heart disease death) and all-cause mortality were identified through active participant follow-up. Results: Overall, 5.1%, 28.9%, 36.9%, 21.7% and 7.5% had 0, 1, 2, 3, and >= 4 of the 5 healthy lifestyle factors studied. There were 377 incident ASCVD events (203 CHD events and 174 strokes) and 471 deaths during 5.8 and 6.0 median years of follow-up, respectively. ASCVD incidence rates (95% Cl) per 1000-person-years associated with 0, 1, 2, 3 and >= 4 healthy lifestyles were 134 (7.3-19.5), 12.8 (10A-152), 11.0 (9.0-12.9), 11.0 (8.313.7), and 87(49-124), respectively. Mortality rates associated with 0, 1, 2, 3 and a4 healthy lifestyles were 20.6 (13.3-27.8), 15.9 (13.3-18.5), 13.1 (10.9-15.2), 12.6 (9.9-15.2) ancl 9.2 (5.3-13.2) per 1000-person years, respectively. The use of more healthy lifestyles was associated with lower risks for ASCVD and mortality after multivariable adjustment. Conclusion: Healthy lifestyles arc underutilized among high-risk US adults and may substantially reduce their ASCVD risk. (C) 2016 Published by Elsevier Ireland Ltd.

【 授权许可】

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