Statin therapy modulates thickness and inflammatory profile of human epicardial adipose tissue

INTERNATIONAL JOURNAL OF CARDIOLOGY

卷:274

Article

Parisi, Valentina¹  Petraglia, Laura¹  D'Esposito, Vittoria¹  Cabaroa, Serena¹  Rengo, Giuseppe¹  Caruso, Aurelio²  Grimaldi, Maria Gabriella²  Baldascino, Francesco²  De Bellis, Antonio²  Vitale, Dino²  Formisano, Roberto¹  Ferro, Adele³  Paolillo, Stefania⁴  Davin, Laurent⁵  Lancellotti, Patrizio^5,6  Formisano, Pietro¹  Filardi, Pasquale Perrone⁷  Ferrara, Nicola¹  Leosco, Dario¹ 

[1] Univ Naples Federico II, Dept Translat Med Sci, Via S Pansini 5, I-80131 Naples, Italy

[2] Casa Cura San Michele, Maddaloni, CE, Italy

[3] CNR, Inst Biostruct & Bioimaging, Naples, Italy

[4] Italy SDN Fdn, Inst Diagnost & Nucl Dev, Naples, Italy

[5] CHU Sart Tilman, Univ Liege Hosp, GIGA Cardiovasc Sci, Dept Cardiol,Heart Valve Clin, Liege, Belgium

[6] Anthea Hosp, Grp Villa Maria Care & Res, Bari, Italy

[7] Univ Federico II Naples, Dept Adv Biomed Sci, Naples, Italy

关键词: Epicardial adipose tissue;    Statin;    Inflammation;    Aortic stenosis;   

DOI  :  10.1016/j.ijcard.2018.06.106

来源: Elsevier

【 摘 要 】

Background: Epicardial adipose tissue (EAT) thickness and pro-inflammatory status has been shown to be associated with several cardiac diseases, including aortic stenosis (AS). Thus, cardiac visceral fat could represent a potential new target for drugs. In the present study we evaluate the effect of statin therapy on EAT accumulation and inflammation. Methods: Echocardiographic EAT thickness was assessed in 193 AS patients taking (n.87) and not taking (n.106) statins, undergoing cardiac surgery. To explore the association between statin therapy and EAT inflammation, EAT biopsies were obtained for cytokines immunoassay determination in EAT secretomes. An in vitro study was also conducted and the modulation of EAT and subcutaneous adipose tissue (SCAT) secretomes by atorvastatin was assessed in paired biopsies. Results: Statin therapy was significantly associated with lower EAT thickness (p < 0.0001) and with lower levels of EAT-secreted inflammatory mediators (p < 0.0001). Of note, there was a significant correlation between EAT thickness and its pro-inflammatory status. In vitro, atorvastatin showed a direct anti-inflammatory effect on EAT which was significantly higher compared to the SCAT response to statin incubation (p < 0.0001). Conclusions: The present study indicates a robust association between statin therapy and reduced EAT accumulation in patients with AS. The present data also suggest a direct relationship between EAT thickness and its inflammatory status, both modulated by statin therapy. The in vitro results support the hypothesis of a direct action of statins on EAT secretory profile. Overall our data suggest EAT as a potential new therapeutic target for statin therapy. (c) 2018 Elsevier B.V. All rights reserved.

【 授权许可】

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