Role of inflammatory signaling in atrial fibrillation

INTERNATIONAL JOURNAL OF CARDIOLOGY

卷:287

Review

Scott, Larry, Jr.^1,2  Li, Na^1,2,3  Dobrev, Dobromir⁴ 

[1] Baylor Coll Med, Dept Med, Sect Cardiovasc Res, Houston, TX 77030 USA

[2] Baylor Coll Med, Dept Mol Physiol & Biophys, Houston, TX 77030 USA

[3] Baylor Coll Med, Cardiovasc Res Inst, Houston, TX 77030 USA

[4] Univ Duisburg Essen, West German Heart & Vasc Ctr, Inst Pharmacol, Essen, Germany

关键词: Atrial fibrillation;    Inflammation;    Inflammasome;    TNF-alpha;    NF kappa B;    IL-1 beta;   

DOI  :  10.1016/j.ijcard.2018.10.020

来源: Elsevier

【 摘 要 】

Atrial fibrillation (AF), the most prevalent arrhythmia, is often associated with enhanced inflammatory response. Emerging evidence points to a causal role of inflammatory signaling pathways in the evolution of atrial electrical, calcium handling and structural remodeling, which create the substrate of AF development. In this review, we discuss the clinical evidence supporting the association between inflammatory indices and AF development, the molecular and cellular mechanisms of AF, which appear to involve multiple canonical inflammatory pathways, and the potential of anti-inflammatory therapeutic approaches in AF prevention/treatment. (c) 2018 Elsevier B.V. All rights reserved.

【 授权许可】

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