Ascending aortic aneurysm and aortic valve dysfunction in bicuspid aortic valve disease

INTERNATIONAL JOURNAL OF CARDIOLOGY

卷:164

Article

Aydin, Ali¹  Desai, Nikolaus¹  Bernhardt, Alexander M. J.¹  Treede, Hendrik¹  Detter, Christian¹  Sheikhzadeh, Sara¹  Rybczynski, Meike¹  Hillebrand, Mathias¹  Lorenzen, Victoria¹  Mortensen, Kai³  Robinson, Peter N.⁴  Berger, Juergen²  Reichenspurner, Hermann¹  Meinertz, Thomas¹  Willems, Stephan¹  von Kodolitsch, Yskert¹ 

[1] Univ Hosp Eppendorf, Ctr Cardiol & Cardiovasc Surg, Hamburg, Germany

[2] Univ Hosp Eppendorf, Dept Med Biometry & Epidemiol, Hamburg, Germany

[3] Med Univ Lubeck, Med Clin 2, Lubeck, Germany

[4] Charite Univ Med Berlin, Inst Med Genet, Berlin, Germany

关键词: Bicuspid aortic valve;    Aortic dilatation;    Aortic valve stenosis;    Aortic valve regurgitation;    Surgery;   

DOI  :  10.1016/j.ijcard.2011.07.018

来源: Elsevier

【 摘 要 】

Background: The relationship of aortic valve dysfunction and ascending aortic aneurysm is unclear in adults with bicuspid aortic valve disease. Methods: We retrospectively studied 134 consecutive out-patients (98 men, 36 women aged 43 +/- 18 years) with bicuspid aortic valve disease. To investigate the relationship of ascending aortic aneurysm and aortic valve dysfunction we exclusively considered severe pathologies that required treatment by surgical or percutaneous intervention. Results: Of 134 patients, 39 had aortic valve dysfunction without concomitant ascending aortic aneurysm which had been treated previously with isolated valve surgery or percutaneous valvuloplasty comprising 25 patients with aortic stenosis (19%) and 14 patients with aortic regurgitation (10%). Conversely, 26 patients had ascending aortic aneurysm which had been treated previously with aortic surgery (19%). Of these, ascending aortic aneurysm was associated with severe aortic stenosis in 13 patients and with severe aortic regurgitation in 7 patients, whereas aneurysm was unrelated to severe aortic valve dysfunction in the remaining 6 patients including 2 without any degree of aortic valve dysfunction. The maximal aortic diameters were similar at the time of aortic surgery irrespective of presence of severe aortic valve dysfunction (P=.527). Other characteristics of patients with ascending aortic aneurysm were also similar irrespective of presence or type of aortic valve dysfunction. Conclusion: The majority of patients with bicuspid aortic valve disease exhibit ascending aortic aneurysm in conjunction with severe aortic valve dysfunction. However, in our study 6 of 134 (5%) of persons with bicuspid aortic valve disease developed ascending aortic aneurysm without aortic valve dysfunction. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

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