Correlation between cardio-pulmonary exercise test variables and health-related quality of life among children with congenital heart diseases

INTERNATIONAL JOURNAL OF CARDIOLOGY

卷:203

Article

Amedro, P.^1,4,5  Picot, M. C.^2,6  Moniotte, S.³  Dorka, R.¹  Bertet, H.^3,6  Guillaumont, S.^1,7  Barrea, C.³  Vincenti, M.^1,4  De La Villeon, G.^1,7  Bredy, C.¹  Soulatges, C.¹  Voisin, M.¹  Matecki, S.^4,8  Auquier, P.⁵ 

[1] Univ Hosp, Pediat & Congenital Cardiol Dept, Montpellier, France

[2] Univ Hosp, Epidemiol & Clin Res Dept, Montpellier, France

[3] UCL, St Luc Univ Hosp, Pediat & Congenital Cardiol Dept, Brussels, Belgium

[4] Univ Montpellier, Physiol & Expt Biol Heart & Muscles Lab PHYMEDEXP, UMR CNRS 9214, INSERM U1046, F-34059 Montpellier, France

[5] Mediterranean Med Sch, Dept Publ Hlth, Self Perceived Hlth Assessment Res Unit, EA3279, Marseille, France

[6] INSERM CIC 1411, Clin Invest Ctr, Montpellier, France

[7] St Pierre Inst, Pediat Cardiol & Rehabil Unit, Pafavas Les Elots, France

[8] Univ Hosp, Dept Physiol, Pediat Funct Explorat Lab, Montpellier, France

关键词: Quality of life;    Cardio-pulmonary exercise test;    Congenital heart disease;    Peak VO2;    Pediatrics;   

DOI  :  10.1016/j.ijcard.2015.11.028

来源: Elsevier

【 摘 要 】

Background: Health-related quality of life (HR-QoL) stands as a determinant patient-related outcome and correlates with cardio-pulmonary exercise test (CPET) in adults with chronic heart failure or with a congenital heart disease (CHD). No such correlation has been established in pediatric cardiology. Methods and results: 202 CHD children aged 8 to 18 performed a CPET (treadmill n = 96, cycle-ergometer n = 106). CHD severity was stratified into 4 groups. All children and parents filled out the Kidscreen HR-QoL questionnaire. Peak VO2, anaerobic threshold (AT), and oxygen pulse followed a downward significant trend with increasing CHD severity and conversely for VE/VCO2 slope. Self-reported and parent-reported physical well-being HR-QoL scores correlated with peak VO2 (respectively r = 0.27, p < 0.0001 and r = 0.43, p < 0.0001), percentage of predicted peak VO2 (r = 0.28, p = 0.0001 and r = 0.41, p < 0.0001), and percentage of predicted VO2 at AT (r = 0.22, p < 0.01 and r = 0.31, p < 0.0001). Significant correlations were also observed between several HR-QoL dimensions and dead space to tidal volume ratio (VD/VT), oxygen uptake efficiency slope (OUES), oxygen pulse but never with VE/VCO2 slope. The strongest correlations were observed in the treadmill group, especially between peak VO2 and physical well-being for parents (r = 0.57, p < 0.0001) and self (r = 0.40, p < 0.0001) reported HR-QoL. Conclusions: Peak VO2 and AT are the two CPET variables that best correlated with HR-QoL in this large pediatric cohort, parents' reports being more accurate. If HR-QoL is involved as a PRO in a pediatric cardiology clinical trial, we suggest using parents related physical well-being HR-QoL scores. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

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