Response to cardiac resynchronization therapy is determined by intrinsic electrical substrate rather than by its modification

INTERNATIONAL JOURNAL OF CARDIOLOGY

卷:270

Article

Strik, Marc^1,2,3  Ploux, Sylvain^1,2  Huntjens, Peter R.^1,2,3  Nguyen, Uyen Chau³  Frontera, Antionio^1,2  Eschalier, Romain⁴  Dubois, Remi^1,2  Ritter, Philippe^1,2  Klotz, Nicholas^1,2  Vernooy, Kevin^3,5  Haissaguerre, Michel^1,2  Crijns, Harry J. G. M.³  Prinzen, Frits W.³  Bordachar, Pierre^1,2 

[1] Fdn Bordeaux Univ, Electrophysiol & Heart Modeling Inst, IHU Liryc, F-33600 Bordeaux, France

[2] Bordeaux Univ Hosp CHU, Cardiothorac Unit, F-33600 Pessac, France

[3] Maastricht Univ, Med Ctr, Cardiovasc Res Inst Maastricht, Maastricht, Netherlands

[4] CHU Clermont Ferrand, Clermont Ferrand, France

[5] Radboud Univ Nijmegen, Med Ctr, Nijmegen, Netherlands

关键词: Left bundle branch block;    Cardiac resynchronization therapy;    Cardiac resynchronization;    Cardiac mapping;    Heart failure;   

DOI  :  10.1016/j.ijcard.2018.06.005

来源: Elsevier

【 摘 要 】

Background: Electrocardiographic mapping (ECM) expresses electrical substrate through magnitude and direction of the activation delay vector (ADV). We investigated to what extent the response to cardiac resynchronization therapy (CRT) is determined by baseline ADV and by ADV modification through CRT and optimization of left ventricular (LV) pacing site. Methods: ECM was performed in 79 heart failure patients (4 RBBB, 12 QRS <120 ms, 23 non-specific conduction delay [NICD] and 40 left bundle branch block [LBBB]). 67 patients (QRS >= 120 ms) underwent CRT implantation and in 26 patients multiple LV pacing site optimization was performed. ADV was calculated from locations/depolarization times of 2000 virtual epicardial electrodes derived from ECM. Acute response was defined as >= 10% LVdP/dt(max) increase, chronic response by composite clinical score at 6 months. Results: During intrinsic conduction, ADV direction was similar in patients with QRS < 120 ms, NICD and LBBB, pointing towards the LV free wall, while ADV magnitude was larger in LBBB (117 +/- 25 ms) than in NICD (70 +/- 29 ms, P < 0.05) and QRS < 120 ms (52 +/- 14 ms, P < 0.05). Intrinsic ADV accurately predicted the acute (AUC = 0.93) and chronic (AUC = 0.90) response to CRT. ADV change by CRT only moderately predicted response (highest AUC = 0.76). LV pacing site optimization had limited effects: +3 +/- 4% LVdP/dt(max) when compared to conventional basolateral LV pacing. Conclusion: The baseline electrical substrate, adequately measured by ADV amplitude, strongly determines acute and chronic CRT response, while the extent of its modification by conventional CRT or by varying LV pacing sites has limited effects. (c) 2018 Elsevier B.V. All rights reserved.

【 授权许可】

Free