Novel blood pressure targets in patients with high-normal levels and grade 1 hypertension: Room for monotherapy?

INTERNATIONAL JOURNAL OF CARDIOLOGY

卷:291

Article

Volpe, Massimo^1,2  Gallo, Giovanna¹  Tocci, Giuliano^1,2 

[1] Sapienza Univ Rome, Sch Med & Psychol, Dept Clin & Mol Med, Rome, Italy

[2] IRCCS Neuromed, Pozzilli, Italy

关键词: Hypertension;    Blood pressure targets;    Monotherapy;    Stroke;    Cardiovascular risk;   

DOI  :  10.1016/j.ijcard.2019.04.074

来源: Elsevier

【 摘 要 】

The 2018 European and 2017 American guidelines recommend to start antihypertensive treatment with combinations of two or more drugs in most hypertensive patients, as a consequence of the suggested more ambitious blood pressure (BP) targets (systolic BP between 130 and 120 mmHg in most patients, diastolic BP between 80 and 70 mmHg). Monotherapy, however, is still suggested as first choice in some specific classes of patients. In this article, we analyze the subgroups of hypertensive patients that should properly started and even maintained on monotherapy, with a focus on subjects with BP in the high-normal range or grade 1 hypertension, young adults with estimated low cardiovascular risk, women during pregnancy or menopause, elderly patients aged >80 years or with frailty parameters. Altogether, these subgroups cover a relatively large proportion of patients with hypertension. Thus, we conclude that, despite the upgrowing role of combination therapy, there is still ample room for the approach with monotherapy in clinical management of hypertension. (C) 2019 The Authors. Published by Elsevier B.V.

【 授权许可】

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