JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY | 卷:83 |
Immune checkpoint inhibitors to treat cutaneous malignancies | |
Review | |
Barrios, Dulce M.1  Do, Mytrang H.1,2  Phillips, Gregory S.3  Postow, Michael A.2,4  Akaike, Tomoko5  Nghiem, Paul5  Lacouture, Mario E.1,2  | |
[1] Mem Sloan Kettering Canc Ctr, Dermatol Serv, Dept Med, 530 E 74th St, New York, NY 10021 USA | |
[2] Weill Cornell Med, New York, NY USA | |
[3] SUNY Downstate Hlth Sci Univ, Brooklyn, NY USA | |
[4] Mem Sloan Kettering Canc Ctr, Dept Med, Melanoma Serv, New York, NY 10021 USA | |
[5] Univ Washington, Sch Med, Dept Med, Div Dermatol, Seattle, WA 98195 USA | |
关键词: basal cell carcinoma; checkpoint inhibitor; CTLA-4 inhibitor; cutaneous lymphomas; cutaneous malignancies; cutaneous squamous cell carcinoma; immunotherapy; Kaposi sarcoma; melanoma; Merkel cell carcinoma; PD-1 inhibitor; PD-L1 inhibitor; skin cancer; | |
DOI : 10.1016/j.jaad.2020.03.131 | |
来源: Elsevier | |
【 摘 要 】
As the incidence of cutaneous malignancies continues to rise and their treatment with immunotherapy expands, dermatologists and their patients are more likely to encounter immune checkpoint inhibitors. While the blockade of immune checkpoint target proteins (cytotoxic T-lymphocyte-associated protein-4, programmed cell death-1, and programmed cell death ligand-1) generates an antitumor response in a substantial fraction of patients, there is a critical need for reliable predictive biomarkers and approaches to address refractory disease. The first article of this Continuing Medical Education series reviews the indications, efficacy, safety profile, and evidence supporting checkpoint inhibition as therapeutics for metastatic melanoma, cutaneous squamous cell carcinoma, and Merkel cell carcinoma. Pivotal studies resulting in the approval of ipilimumab, pembrolizumab, nivolumab, cemiplimab, and avelumab by regulatory agencies for various cutaneous malignancies, as well as ongoing clinical research trials, are discussed.
【 授权许可】
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【 预 览 】
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10_1016_j_jaad_2020_03_131.pdf | 1257KB | download |