Role of imaging in low-grade cutaneous B-cell lymphoma presenting in the skin

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

卷:81

Article

Kheterpal, Meenal K.^1,2  Dai, Julia³  Geller, Shamir¹  Pulitzer, Melissa⁴  Ni, Andy⁵  Myskowski, Patricia L.¹  Moskowitz, Alison⁶  Kim, Jinah⁷  Hong, Eric K.³  Fong, Sophia³  Hoppe, Richard T.⁸  Kim, Youn H.⁹  Horwitz, Steven M.⁶ 

[1] Mem Sloan Kettering Canc Ctr, Dept Med, Dermatol Serv, New York, NY 10021 USA

[2] Duke Univ, Dept Dermatol, 40 Duke Med Cir, Durham, NC 27710 USA

[3] Stanford Univ, Dept Dermatol, Stanford, CA 94305 USA

[4] Mem Sloan Kettering Canc Ctr, Dept Pathol, 1275 York Ave, New York, NY 10021 USA

[5] Mem Sloan Kettering Canc Ctr, Dept Biostat, New York, NY 10021 USA

[6] Mem Sloan Kettering Canc Ctr, Dept Med, Lymphoma Serv, 1275 York Ave, New York, NY 10021 USA

[7] Stanford Univ, Dept Pathol, Stanford, CA 94305 USA

[8] Stanford Univ, Dept Radiat Oncol, Stanford, CA 94305 USA

[9] Stanford Univ, Dept Dermatol & Med, Stanford, CA 94305 USA

关键词: imaging;    primary cutaneous B-cell lymphoma;    prognosis;    systemic involvement of cutaneous B-cell lymphoma;   

DOI  :  10.1016/j.jaad.2019.01.037

来源: Elsevier

【 摘 要 】

Background: Whole-body imaging is the current standard of care for staging all patients presenting with skin lesions of B-cell lymphomas (BCLs), regardless of skin disease extent; however, supporting data are lacking. Objective: To determine the clinical utility of imaging in the detection of systemic involvement in low-grade cutaneous BCLs in the skin. Methods: Retrospective cohort analysis of patients presenting with cutaneous lesions of BCLs at Memorial Sloan Kettering Cancer Center and Stanford University during 1997-2016. Results: At initial staging, of the 522 patients, extracutaneous disease was noted in 3.6% and 8.8% of patients with marginal zone lymphoma (MZL, n = 306) and follicle center lymphoma (FCL, n = 216) histology, respectively. In patients with systemic involvement, imaging alone identified 81.8% (9/11) of MZL cases and 89.4% of follicular lymphoma cases. In primary cutaneous MZL, 1.7% of patients subsequently had extracutaneous involvement (median follow-up 45 months), and in primary cutaneous FCL. 3.0% subsequently had extracutaneous involvement (median follow-up 47 months). Limitations: This was a retrospective study. Conclusion: Imaging is effective at identifying patients with systemic involvement in indolent BCLs present in the skin; however, incidence is low. After negative initial staging, primary cutaneous MZL patients may be followed clinically without routine imaging.

【 授权许可】

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