Red meat and processed meat intake and risk for cutaneous melanoma in white women and men: Two prospective cohort studies

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

卷:79

Article

Yen, Hsi^1,2,3,4  Li, Wen-Qing^5,6  Dhana, Ashar^1,7,8  Li, Tricia^9,10  Qureshi, Abrar^5,6,9,10  Cho, Eunyoung^5,6,9,10 

[1] Harvard TH Chan Sch Publ Hlth, Boston, MA USA

[2] Chang Gung Mem Hosp Linkou, Taoyuan, Taiwan

[3] Taipei Branch, Taoyuan, Taiwan

[4] Chang Gung Univ, Coll Med, Taoyuan, Taiwan

[5] Brown Univ, Dept Dermatol, Warren Alpert Med Sch, Box G-D, Providence, RI 02912 USA

[6] Brown Univ, Sch Publ Hlth, Dept Epidemiol, Providence, RI 02912 USA

[7] Groote Schuur Hosp, Div Dermatol, Cape Town, South Africa

[8] Univ Cape Town, Cape Town, South Africa

[9] Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA

[10] Harvard Med Sch, Boston, MA USA

关键词: cutaneous melanoma;    processed meat;    prospective cohort study;    red meat;    skin cancer;   

DOI  :  10.1016/j.jaad.2018.04.036

来源: Elsevier

【 摘 要 】

Background: Red and processed meat consumption has been associated with increased risk for several cancers, but the association with cutaneous melanoma risk has been inconclusive. Objective: To investigate the association between red and processed meat intake and melanoma risk. Methods: Dietary information was assessed by using food frequency questionnaires in 2 prospective cohorts: 75,263 women from the Nurses' Health Study (1984-2010) and 48,523 men from the Health Professionals Follow-up Study (1986-2010). Melanoma cases were confirmed by reviewing pathology records. Pooled multivariable hazard ratios and 95% confidence intervals were estimated by using Cox proportional hazards models. Results: A total of 679 female and 639 male melanoma cases were documented during follow-up. Red and processed meat intake was inversely associated with melanoma risk (P=.002 for trend); the pooled hazard ratios (95% confidence intervals) of the 2 cohorts were 1.00 (reference), 1.00 (0.87-1.14), 0.98 (0.86-1.13), 0.89 (0.77-1.02), and 0.81 (0.70-0.95) for increasing quintiles of intake. Limitations: Findings might have limited generalizability, considering that the cohorts were limited to white health professionals. Conclusion: Red and processed meat intake was inversely associated with melanoma risk in these 2 cohorts.

【 授权许可】

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