COVID-19 vaccine safety and efficacy in patients with immune-mediated inflammatory disease: Review of available evidence

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

卷:85

Review

Wack, Sarah¹  Patton, Timothy¹  Ferris, Laura K.¹ 

[1] Univ Pittsburgh, Sch Med, Dept Dermatol, Pittsburgh, PA 15260 USA

关键词: atopic dermatitis;    autoimmune disease;    autoimmunity;    biologics;    COVID-19;    dermatomyositis;    hidradenitis suppurativa;    IMID;    MCTD;    myositis;    pemphigoid;    pemphigus;    psoriasis;    sarcoid;    SARS-CoV-2;    sclerosis;    Systemic Lupus Erythematosus;    vaccines;    vasculitis;   

DOI  :  10.1016/j.jaad.2021.07.054

来源: Elsevier

【 摘 要 】

Dermatologists diagnose and treat many immune-mediated inflammatory diseases (IMID). Understanding the inherent immune dysregulation of these diseases as well as the additional disruption that comes as a result of IMID treatments has been important during the COVID-19 pandemic. With vaccines becoming widely available, dermatologists need to be familiar with the risks and benefits of vaccination in these patients, particularly those taking biologics, in order to have informed discussions with their patients. In this review, we present the current evidence related to COVID-19 vaccine safety and efficacy in patients with IMID and review existing recommendations for vaccination against SARS-CoV-2. Given the current evidence, there is minimal concern that these patients are at any greater risk of harm from COVID-19 vaccination compared to healthy controls. For most, the benefit of avoiding severe COVID-19 through vaccination will outweigh the theoretical risk of these vaccines. A question that is still outstanding is whether patients on biologics will generate a sufficient immune response to the vaccine, which may be dependent on the specific biologic therapy and indication being treated. This underscores the importance of following patients with IMID after vaccination to determine the safety, efficacy, and duration of the vaccine in this population. ( J Am Acad Dermatol 2021;85:1274-84.)

【 授权许可】

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