JAK inhibitors in dermatology: The promise of a new drug class

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

卷:76

Review

Damsky, William¹  King, Brett A.¹ 

[1] Yale Sch Med, Dept Dermatol, New Haven, CT USA

关键词: alopecia areata;    atopic dermatitis;    baricitinib;    JAK inhibitor;    JAK-STAT;    psoriasis;    ruxolitinib;    tofacitinib;    vitiligo;   

DOI  :  10.1016/j.jaad.2016.12.005

来源: Elsevier

【 摘 要 】

New molecularly targeted therapeutics are changing dermatologic therapy. Janus kinase-signal transducer and activator of transcription (JAK-STAT) is an intracellular signaling pathway upon which many different proinflammatory signaling pathways converge. Numerous inflammatory dermatoses are driven by soluble inflammatory mediators, which rely on JAK-STAT signaling, and inhibition of this pathway using JAK inhibitors might be a useful therapeutic strategy for these diseases. Growing evidence suggests that JAK inhibitors are efficacious in atopic dermatitis, alopecia areata, psoriasis, and vitiligo. Additional evidence suggests that JAK inhibition might be broadly useful in dermatology, with early reports of efficacy in several other conditions. JAK inhibitors can be administered orally or used topically and represent a promising new class of medications. The use of JAK inhibitors in dermatology is reviewed here.

【 授权许可】

Free