Systemic treatment and narrowband ultraviolet B differentially affect cardiovascular risk markers in psoriasis

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

卷:70

Article

Sigurdardottir, Gunnthorunn¹  Ekman, Anna-Karin¹  Stahle, Mona²  Bivik, Cecilia¹  Enerback, Charlotta¹ 

[1] Linkoping Univ, Fac Hlth Sci, Ingrid Asp Psoriasis Res Ctr, Dept Clin & Expt Med, SE-58185 Linkoping, Sweden

[2] Karolinska Inst, Dept Med, Unit Dermatol & Venereol, Stockholm, Sweden

关键词: cardiovascular risk;    matrix metalloproteinase-9;    myeloperoxidase;    psoriasis;    soluble E-selectin;    soluble intercellular adhesion molecule-1;    soluble vascular cell adhesion molecule-1;    total plasminogen activator inhibitor-1;    tumor necrosis factor-alfa inhibitor;    ultraviolet B;   

DOI  :  10.1016/j.jaad.2013.12.044

来源: Elsevier

【 摘 要 】

Background: Psoriasis is associated with a systemic inflammation and an increased frequency of the metabolic syndrome, both of which are believed to link psoriasis to an increased risk of cardiovascular disease. Objective: The study aimed to investigate the systemic expression of markers of cardiovascular risk and determine their response to ultraviolet B therapy and treatment with the tumor necrosis factor-alfa inhibitor, etanercept. Methods: Six markers of cardiovascular risk were measured in 28 patients with psoriasis and 28 control subjects. Results: Five of the 6 investigated markers were elevated in patients with psoriasis. Four of these correlated to the body mass index and waist-hip ratio, suggesting a link to the metabolic syndrome. Total plasminogen activator inhibitor-1 remained elevated independently of these factors. The levels of the investigated risk markers decreased considerably after tumor necrosis factor-alfa inhibitor treatment but remained unaffected by ultraviolet therapy. Limitations: A relatively limited study population and nonrandomization are limitations. Conclusion: These findings suggest that the choice of treatment in psoriasis may influence the cardiovascular risk in patients with psoriasis and the metabolic syndrome.

【 授权许可】

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