Adverse reactions to injectable soft tissue fillers

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

卷:64

Article

Requena, Luis¹  Requena, Celia²  Christensen, Lise³  Zimmermann, Ute S.⁴  Kutzner, Heinz⁵  Cerroni, Lorenzo⁶ 

[1] Univ Autonoma, Fdn Jimenez Diaz, Dept Dermatol, Madrid 28040, Spain

[2] Inst Valenciano Oncol, Valencia, Spain

[3] Univ Hosp, Bispebjerg Hosp, Dept Pathol, Copenhagen, Denmark

[4] Ctr Pathol Cutanee Roquette, Paris, France

[5] Dermatopathol Gemeinschaftspraxis, Friedrichshafen, Germany

[6] Graz Univ, Dept Dermatol, Graz, Austria

关键词: adverse reactions;    bovine collagen;    calcium hydroxylapatite;    dextranomers;    fillers;    histopathology;    hyaluronic acid;    paraffin;    polyacrylamide;    polyalkylimide;    poly-L-lactic acid;    polymethylmethacrylate;    polyvinylhydroxide;    polyvinylpyrrolidone;    silicone;   

DOI  :  10.1016/j.jaad.2010.02.064

来源: Elsevier

【 摘 要 】

In recent years, injections with filler agents are often used for wrinkle-treatment and soft tissue augmentation by dermatologists and plastic surgeons. Unfortunately, the ideal filler has not yet been discovered and all of them may induce adverse reactions. Quickly biodegradable or resorbable agents may induce severe complications, but they will normally disappear spontaneously in a few months. Slowly biodegradable or nonresorbable fillers may give rise to severe reactions that show little or no tendency to spontaneous improvement. They may appear several years after the injection, when the patient does not remember which product was injected, and treatment is often insufficient. In this review, we discuss the most commonly used fillers, their most frequent adverse reactions as well as the characteristic histopathlogic findings that allow the identification of the injected filler agent. In conclusion, histopathologic study remains as the gold standard technique to identify the responsible filler. (J Am Acad Dermatol 2011;64:1-34.) Learning objectives: After completing this learning activity, participants should be able to recognize the most frequent adverse reactions induced by cosmetic fillers, identify their histopathologic characteristics so that they can be distinguished from each other, and advise their patients with adverse reactions about the different nature of these according to the filler for subsequent successful treatment.

【 授权许可】

Free