Incidence of lentigo maligna in Olmsted County, Minnesota, 1970 to 2007

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

卷:70

Article

Mirzoyev, Sultan A.³  Knudson, Richelle M.¹  Reed, Kurtis B.¹  Hou, Jennifer L.³  Lohse, Christine M.²  Frohm, Marcus L.¹  Brewer, Jerry D.¹  Otley, Clark C.¹  Roenigk, Randall K.¹ 

[1] Mayo Clin, Div Dermatol Surg, Rochester, MN 55905 USA

[2] Mayo Clin, Div Biomed Stat & Informat, Rochester, MN 55905 USA

[3] Mayo Clin, Coll Med, Mayo Med Sch, Rochester, MN 55905 USA

关键词: excision;    incidence;    lentigo maligna;    lentigo maligna melanoma;    melanoma;    melanoma in situ;    Mohs micrographic surgery;    Rochester Epidemiology Project;   

DOI  :  10.1016/j.jaad.2013.11.008

来源: Elsevier

【 摘 要 】

Background: The incidence of lentigo maligna (LM) may be increasing, but no population-based epidemiologic studies have been performed to our knowledge. Objective: We sought to determine the incidence of LM in Olmsted County, Minnesota, along with overall and recurrence-free survival. Methods: Using the Rochester Epidemiology Project, we identified all adult residents of Olmsted County, Minnesota, with a first lifetime diagnosis of LM between 1970 and 2007. Medical records were reviewed to determine demographic, clinical, and surgical data, and incidence and survival were calculated. Results: Among 145 patients identified, median (range) age at diagnosis of LM was 70 (33-97) years. Treatment changed over time, with Mohs micrographic surgery becoming available after 1986. No patients died of LM; 5 had local recurrence. Estimated local recurrence-free survival at 5, 10, 15, and 20 years after diagnosis was 98%, 96%, 92%, and 92%, respectively. Overall age-and sex-adjusted incidence of LM among adults was 6.3 per 100,000 person-years, increasing from 2.2 between 1970 and 1989 to 13.7 between 2004 and 2007. Limitations: Retrospective study design and homogeneous population are limitations. Conclusion: The incidence of LM increased significantly among residents of Olmsted County, Minnesota, over an extended time frame, with incidence being significantly higher among men than women and increasing with age.

【 授权许可】

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