The prognostic value of inositol polyphosphate 5-phosphatase in cutaneous squamous cell carcinoma

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

卷:80

Article

Cumsky, Helen J. L.^1,3  Costello, Collin M.¹  Zhang, Nan²  Butterfield, Richard²  Buras, Matthew R.²  Schmidt, Jessica E.¹  Drenner, Kevin¹  Nelson, Steven A.¹  Ochoa, Shari A.¹  Baum, Christian L.⁴  Pittelkow, Mark R.¹  DiCaudo, David J.¹  Sekulic, Aleksandar¹  Mangold, Aaron R.¹ 

[1] Mayo Clin, Dept Dermatol, Scottsdale, AZ USA

[2] Mayo Clin, Dept Hlth Sci Res, Scottsdale, AZ USA

[3] Case Western Reserve Univ, Sch Med, Cleveland, OH USA

[4] Mayo Clin, Dept Dermatol, Rochester, MN USA

关键词: biomarker;    cancer tumor marker;    cutaneous squamous cell carcinoma;    inositol polyphosphate-5-phosphatase;    metastases;    outcome;    prognosis;    prognostic marker;    recurrence;    squamous cell carcinoma;    staging;   

DOI  :  10.1016/j.jaad.2018.10.018

来源: Elsevier

【 摘 要 】

Background: Inositol polyphosphate 5-phosphatase (INPP5A) has been shown to play a role in development and progression of cutaneous squamous cell carcinoma (cSCC). The goal of the current study was to explore the prognostic value of INPP5A expression in cSCC. Methods: A total of 189 cases of actinic keratosis and SCC in 174 patients were identified; clinical and outcome data were abstracted, histopathology was rereviewed, and immunohistochemical staining and interpretation was performed for INPP5A. Results: The majority of tumors (89.4%) had an INPP5A score of 2 or 3. No patients had complete loss of INPP5A. Tumors with an INPP5A score of 1 were more likely to be intermediate-to high-risk tumors (Brigham and Women's Hospital stage >= T2a 85.0% vs 23.7% [P < .0001]) characterized by a larger diameter (2.4 cm vs 1.3 cm [P = .0004]), moderate-to-poor differentiation (86.7% vs 17.6% [P < .0001]), and perineural invasion (37.5% vs 5.3%, [P < .0001]). An INPP5A score of 1 was associated with a worse 3-year survival (a rate of 42.3% [hazard ratio, 2.81, P = .0006]) and a local metastasis rate of 48.0% (hazard ratio, 4.71; P < . 0001). Conclusions: Low INPP5A scores are predictive of aggressive tumors and may be a useful adjunct to guide clinical management of cSCC.

【 授权许可】

Free