Sex differences in the association of cutaneous melanoma incidence rates and geographic ultraviolet light exposure

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

卷:76

Article

Liu-Smith, Feng^1,2  Farhat, Ahmed Majid³  Arce, Anthony⁸  Ziogas, Argyrios^1,7  Taylor, Thomas^1,7  Wang, Zi^2,9  Yourk, Vandy⁴  Liu, Jing⁹  Wu, Jun¹  McEligot, Archana J.⁸  Anton-Culver, Hoda^1,7  Meyskens, Frank L.^1,2,5,6 

[1] Univ Calif Irvine, Dept Epidemiol, Sprague Halle,Rm 226, Irvine, CA 92697 USA

[2] Univ Calif Irvine, Dept Med, Irvine, CA USA

[3] Univ Calif Irvine, Dept Biomed Engn, Irvine, CA USA

[4] Univ Calif Irvine, Dept Neurosci, Irvine, CA USA

[5] Univ Calif Irvine, Dept Publ Hlth, Irvine, CA USA

[6] Univ Calif Irvine, Dept Biol Chem, Irvine, CA USA

[7] Univ Calif Irvine, Genet Epidemiol Res Inst, Irvine, CA USA

[8] Calif State Univ, Dept Hlth Sci, Fullerton, CA USA

[9] Cent South Univ, Dept Mol Biol, Changsha, Hunan, Peoples R China

关键词: age-standardized rates;    gender difference;    melanoma;    UV index;    UVI;    sex;   

DOI  :  10.1016/j.jaad.2016.08.027

来源: Elsevier

【 摘 要 】

Background: Cutaneous melanoma (CM) incidence rates continue to increase, and the reasons are unknown. Previously, we reported a unique age-specific sex difference in melanoma that suggested additional causes other than solar ultraviolet (UV) radiation. Objective: This study attempted to understand whether and how UVradiation differentially impacts the CM incidence in men and women. Methods: CM data and daily UV index (UVI) from 31 cancer registries were collected for association analysis. A second dataset from 42 US states was used for validation. Results: There was no association between log-transformed female CM rates and levels of UVI, but there was a significant association between male rates and UVI and a significant association between overall rates and UVI. The 5-year age-specific rate-UVI association levels (represented by Pearson's coefficient rho) increased with age in men, but age-specific rho levels remained low and unchanged in women. The significant rate-UVI association in men and nonassociation in women was validated in a population of white residents of the United States. Limitations: Confounders, including temperature and latitude, are difficult to separate from UVI. Conclusions: Ambient UVI appears to be associated with melanoma incidence in males but not in females.

【 授权许可】

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