PGAxBSA composite versus PASI: Comparison across disease severities and as therapeutic response measure for Cal/BD foam in plaque psoriasis

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

卷:83

Article

Gold, Linda Stein¹  Hansen, Jes B.²  Patel, Dharm²  Veverka, Karen A.²  Strober, Bruce^3,4 

[1] Henry Ford Hosp, Detroit, MI 48202 USA

[2] LEO Pharma Inc, Madison, WI USA

[3] Yale Univ, New Haven, CT USA

[4] Cent Connecticut Dermatol Res, Cromwell, CT USA

关键词: body surface area;    Cal/BD;    extent of disease activity;    mPASI;    psoriasis;    PGA3BSA;    Physician Global Assessment;    severity;   

DOI  :  10.1016/j.jaad.2020.02.077

来源: Elsevier

【 摘 要 】

Background: The product of the Physician Global Assessment and body surface area (PGAxBSA) is simpler to use than the Psoriasis Area and Severity Index (PASI), which lacks sensitivity in patients with mild psoriasis. Objective: To compare the PGAxBSA versus the modified PASI (mPASI) for assessing disease severity and therapeutic response to calcipotriol/betamethasone dipropionate (Cal/BD) foam. Methods: This post hoc analysis evaluated the efficacy of Cal/BD foam in mild, moderate, and severe psoriasis, as assessed by the PGAxBSA and mPASI, using data from 3 randomized controlled trials (NCT01536886, NCT01866163, NCT02132936). Spearman correlation and Bland-Altman plots were used to compare the PGAxBSA with the mPASI. Results: Proportions of patients receiving Cal/BD foam achieving 75% response for PGAxBSA and mPASI at weeks 1, 2, and 4 were similar and significantly greater than with vehicle (P <=.002 at all timepoints); at week 4, mean improvements were 51.0% and 50.7%, respectively. Spearman correlations for mild, moderate, and severe psoriasis were moderate to high between PGAxBSA and mPASI at baseline (r=.51, .72, and .86, respectively; n = 126, 465, and 58, respectively) and high at week 4 (r = .80, .81, and .89, respectively; n = 121, 452, and 58, respectively) (P<001). Limitations: Pooled data from different trials were not prespecified for post hoc analysis. Interrater reliability was not assessed. Conclusion: Pooled data analysis showed that the PGAxBSA and mPASI correlation was higher with increasing psoriasis severity.

【 授权许可】

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