All-cause mortality in patients with basal and squamous cell carcinoma: A systematic review and meta-analysis

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

卷:78

Review

Wehner, Mackenzie R.¹  Serrano, Wilmarie Cidre^2,3  Nosrati, Adi^4,5  Schoen, Patrick Michael⁵  Chren, Mary-Margaret^4,5  Boscardin, John⁶  Linos, Eleni⁵ 

[1] Univ Penn, Dept Dermatol, Philadelphia, PA 19104 USA

[2] Harvard Med Sch, Boston, MA USA

[3] Stanford Univ, Dept Psychiat, Stanford, CA 94305 USA

[4] Vet Affairs Med Ctr, Dermatol Serv, San Francisco, CA 94121 USA

[5] Univ Calif San Francisco, Dept Dermatol, 2340 Sutter St,Room N412, San Francisco, CA 94143 USA

[6] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA

关键词: all-cause mortality;    basal cell carcinoma;    cutaneous squamous cell carcinoma;    keratinocyte carcinoma;    meta-analysis;    systematic review;   

DOI  :  10.1016/j.jaad.2017.11.026

来源: Elsevier

【 摘 要 】

Background: There are varying reports of the association of basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (SCC) with mortality. Objective: To synthesize the available information on all-cause mortality after a diagnosis of BCC or SCC in the general population. Methods: We searched PubMed (1966-present), Web of Science (1898-present), and Embase (1947-present) and hand-searched to identify additional records. All English articles that reported all-cause mortality in patients with BCC or SCC were eligible. We excluded case reports, case series, and studies in subpopulations of patients. Random effects model meta-analyses were performed separately for BCC and SCC. Results: The searches yielded 6538 articles, and 156 were assessed in a full-text review. Twelve studies met the inclusion criteria, and 4 were included in the meta-analysis (encompassing 464,230 patients with BCC and with 175,849 SCC), yielding summary relative mortalities of 0.92 (95% confidence interval, 0.83-1.02) in BCC and 1.25 (95% confidence interval, 1.17-1.32) in SCC. Limitations: Only a minority of studies controlled for comorbidities. There was significant heterogeneity in meta-analysis (chi(2) P < .001, I-2 > 98%), but studies of SCC were qualitatively concordant: all showed statistically significant increased relative mortality. Conclusions: We found that patients with SCC are at higher risk for death from any cause compared with the general population. (J Am Acad Dermatol 2018; 78: 663-72.)

【 授权许可】

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