Hair disorders in patients with cancer

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

卷:80

Article

Freites-Martinez, Azael¹  Shapiro, Jerry³  Goldfarb, Shari²  Nangia, Julie⁴  Jimenez, Joaquin J.^5,6  Paus, Ralf^7,8,9  Lacouture, Mario E.¹ 

[1] Mem Sloan Kettering Canc Ctr, Dept Med, Dermatol Serv, New York, NY 10021 USA

[2] Mem Sloan Kettering Canc Ctr, Breast Canc Med Serv, Div Solid Tumor Oncol, Dept Med, 1275 York Ave, New York, NY 10021 USA

[3] NYU, Sch Med, Ronald O Perelman Dept Dermatol, New York, NY USA

[4] Baylor Coll Med, Dan L Duncan Comprehens Canc Ctr, Sue Smith Breast Ctr, Houston, TX 77030 USA

[5] Univ Miami, Miller Sch Med, Dept Dermatol & Cutaneous Surg, Coral Gables, FL 33124 USA

[6] Univ Miami, Miller Sch Med, Dept Biochem & Mol Biol, Coral Gables, FL 33124 USA

[7] Univ Manchester, Dermatol Res Ctr, Manchester, Lancs, England

[8] Natl Inst Hlth Res Manchester Biomed Res Ctr, Manchester, Lancs, England

[9] Univ Munster, Dept Dermatol, Munster, Germany

关键词: anagen effluvium;    brittleness;    cancer patients;    catagen effluvium;    chemotherapy-induced alopecia;    curling;    depigmentation;    eyebrow alopecia;    eyelash alopecia;    hair repigmentation;    hirsutism;    hyperpigmentation;    hypertrichosis;    hypopigmentation;    straightening;    trichomegaly;   

DOI  :  10.1016/j.jaad.2018.03.055

来源: Elsevier

【 摘 要 】

Cytotoxic chemotherapies, molecularly targeted therapies, immunotherapies, radiotherapy, stem cell transplants, and endocrine therapies may lead to hair disorders, including alopecia, hirsutism, hypertrichosis, and pigmentary and textural hair changes. The mechanisms underlying these changes are varied and remain incompletely understood, hampering the development of preventive or therapeutic guidelines. The psychosocial impact of chemotherapy-induced alopecia has been well documented primarily in the oncology literature; however, the effect of other alterations, such as radiation-induced alopecia, hirsutism, and changes in hair color or texture on quality of life have not been described. This article reviews clinically significant therapy-related hair disorders in oncology patients, including the underlying pathophysiological mechanisms, severity grading scales, patient-reported quality of life questionnaires, management strategies, and future translational research opportunities.

【 授权许可】

Free