Quality of life in dermatomyositis

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

卷:65

Article

Goreshi, Renato^1,2  Chock, Monika³  Foering, Kristen^1,2  Feng, Rui⁴  Okawa, Joyce^1,2  Rose, Matt^1,2  Fiorentino, David³  Werth, Victoria^1,2 

[1] Philadelphia Dept Vet Affairs Med Ctr, Philadelphia, PA USA

[2] Univ Penn, Sch Med, Philadelphia, PA 19104 USA

[3] Stanford Univ, Sch Med, Stanford, CA 94305 USA

[4] Univ Penn, Ctr Clin Epidemiol & Biostat, Philadelphia, PA 19104 USA

关键词: autoimmune disease;    clinical research;    connective tissue disease;    cutaneous lupus;    dermatomyositis;    itch;    pruritus;    quality of life;   

DOI  :  10.1016/j.jaad.2010.10.016

来源: Elsevier

【 摘 要 】

Background: Quality of life (QoL) for patients with inflammatory skin disease can he significant, but has been evaluated in just one study in dermatomyositis (DM). Objective: We sought to examine the relationship between the Cutaneous Dermatomyositis Area (CDASI) and Severity Index, a DM-specific cutaneous severity instrument. and various QoL study instruments and to determine the impact of DM on QoL. Methods: Skin-specific QoL instruments, the Skindex and the Dermatology Life Quality Index, and global medical QoL instruments, the Short Form 36 and the Health Assessment Questionnaire-Disability Index, were used. Pruritus was evaluated by a visual analog scale and a 0-to-10 scale in DM and cutaneous lupus erythematosus (CLE) populations, respectively. Results: There was a significant correlation between the CDASI and all skin-specific QoL scores (lowest P = .0377). Using the Short Form 36, DM population was found to have significantly worse QoL scores than the general population with the exception of bodily pain (all subscore P values < .01). Furthermore, DM had a significantly lower vitality score, representing energy level, compared with CLE, hypertension, diabetes, and recent myocardial infarction scores (lowest P = .003). There was a significantly lower mental health score, representing overall mood, to all compared diseases except CLE and clinical depression (P values < .01 when significant). We found that DM produces more pruritus than CLE (P < .0001). Limitations: A larger patient population needs to be studied to further assess QoL in patients with DM. Conclusion: We conclude that DM has a large impact on QoL, even when compared with other diseases, and that DM skin disease activity correlates with a poorer QoL. (J Am Acad Dermatol 2011;65:1107-16.)

【 授权许可】

Free