Racial differences in mycosis fungoides: A retrospective study with a focus on eosinophilia

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

卷:68

Article

Zampella, John G.^1,3  Hinds, Ginette A.² 

[1] Johns Hopkins Univ, Johns Hopkins Sch Med, Baltimore, MD USA

[2] Johns Hopkins Univ Hosp, Dept Dermatol, Baltimore, MD 21287 USA

[3] Howard Hughes Med Inst, Chevy Chase, MD USA

关键词: black;    cutaneous T-cell lymphoma;    eosinophilia;    ethnic skin;    mycosis fungoides;    race;   

DOI  :  10.1016/j.jaad.2012.11.021

来源: Elsevier

【 摘 要 】

Background: Mycosis fungoides (MF) is often associated with eosinophilia and portends a poorer prognosis. MF is more common in blacks and follows a more aggressive course compared with whites. Objective: We further elucidate racial differences between blacks and whites with MF, focusing on blood eosinophilia. Methods: The records of 345 patients with MF were reviewed for demographic, clinical, and pathologic data and evaluated by analysis of variance. Results: The average age at diagnosis for blacks was 45 years and was 55 years for white patients (P < .001). In the cohorts of patients with and without blood eosinophilia, the average maximum blood eosinophil count had a greater range in blacks. Independent of race, blood eosinophilia was predictive of more advanced disease (P < .0001), increased number of treatment types (P < .002), and less responsiveness to treatment (P < .0006). Limitations: This was a retrospective study at a single institution. Conclusions: These differences observed in eosinophil values may highlight disparities in MF diagnosis or a difference in pathophysiology between races.

【 授权许可】

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