Serum 25-hydroxyvitamin D concentration does not correlate with atopic dermatitis severity

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

卷:69

Article

Chiu, Yvonne E.¹  Havens, Peter L.²  Siegel, Dawn H.¹  Ali, Omar³  Wang, Tao⁴  Holland, Kristen E.¹  Galbraith, Sheila S.¹  Lyon, Valerie B.⁵  Drolet, Beth A.¹ 

[1] Med Coll Wisconsin, Dept Dermatol, Div Pediat Dermatol, Milwaukee, WI 53226 USA

[2] Med Coll Wisconsin, Dept Pediat, Div Infect Dis, Milwaukee, WI 53226 USA

[3] Med Coll Wisconsin, Dept Pediat, Div Endocrinol, Milwaukee, WI 53226 USA

[4] Med Coll Wisconsin, Inst Hlth & Soc, Div Biostat, Milwaukee, WI 53226 USA

[5] Madison Med Affiliates, Milwaukee, WI USA

关键词: asthma;    atopic dermatitis;    atopy;    eczema;    25-hydroxyvitamin D;    vitamin D;   

DOI  :  10.1016/j.jaad.2013.01.010

来源: Elsevier

【 摘 要 】

Background: An inverse correlation between serum 25-hydroxyvitamin D concentration and atopic dermatitis (AD) severity has been suggested. Objective: To determine if a statistically significant relationship exists between serum 25-hydroxyvitamin D concentration and AD severity. Methods: A cross-sectional study was conducted of patients with AD who were 1 to 18 years of age. An objective Severity Scoring of Atopic Dermatitis (SCORAD) and a serum 25-hydroxyvitamin D concentration were measured for each subject. Statistical analysis was performed using appropriate univariate tests and multivariable models. Results: Ninety-four of 97 enrolled subjects were included in the analysis. Vitamin D deficiency (25-hydroxyvitamin D <20 ng/mL) was present in 37 subjects (39%), insufficiency (25-hydroxyvitamin D 21-29 ng/mL) in 33 (35%), and sufficiency (25-hydroxyvitamin D >= 30 ng/mL) in 24 (26%). The correlation between 25-hydroxyvitamin D concentration and SCORAD was not significant (r = -0.001; P = .99). A multivariate model showed that a lower serum 25-hydroxyvitamin D concentration was significantly associated with age 3 years or older (P < .0001), black race (P < .0001), and winter season (P = .0084). Limitations: Limitations of this study include the inability to control for natural sunlight exposure, vitamin D intake, and AD treatment; in addition, only a single time point was captured. Conclusions: Serum 25-hydroxyvitamin D concentration is not significantly correlated with AD severity in our pediatric population.

【 授权许可】

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