Uniform modeling of bacterial colony patterns with varying nutrient and substrate

PHYSICA D-NONLINEAR PHENOMENA

卷:318

Article

Schwarcz, Deborah¹  Levine, Herbert^2,3  Ben-Jacob, Eshel^1,2  Ariel, Gil⁴ 

[1] Tel Aviv Univ, Raymond & Beverly Sackler Fac Exact Sci, Sch Phys & Astron, IL-69978 Tel Aviv, Israel

[2] Rice Univ, Ctr Theoret Biol Phys, Houston, TX 77005 USA

[3] Rice Univ, Dept Bioengn, Houston, TX 77005 USA

[4] Bar Ilan Univ, Dept Math, IL-5290002 Ramat Gan, Israel

关键词: Pattern formation;    Bacterial colonies;    Reaction-diffusion model;    Random lattice;   

DOI  :  10.1016/j.physd.2015.11.002

来源: Elsevier

【 摘 要 】

Bacteria develop complex patterns depending on growth condition. For example, Bacillus subtilis exhibit five different patterns depending on substrate hardness and nutrient concentration. We present a unified integro-differential model that reproduces the entire experimentally observed morphology diagram at varying nutrient concentrations and substrate hardness. The model allows a comprehensive and quantitative comparison between experimental and numerical variables and parameters, such as colony growth rate, nutrient concentration and diffusion constants. As a result, the role of the different physical mechanisms underlying and regulating the growth of the colony can be evaluated. (C) 2015 Elsevier B.V. All rights reserved.

【 授权许可】

Free