Regadenoson: A New Myocardial Stress Agent

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

卷:54

Article

Al Jaroudi, Wael¹  Iskandrian, Ami E.^1,2 

[1] Univ Alabama Birmingham, Dept Med, Div Cardiovasc Dis, Birmingham, AL 35294 USA

[2] Astellas Pharma US Inc, Deerfield, IL USA

关键词: adenosine;    regadenoson;    myocardial perfusion imaging;    single-photon emission computed tomography;    stress testing;   

DOI  :  10.1016/j.jacc.2009.04.089

来源: Elsevier

【 摘 要 】

Vasodilator stress myocardial perfusion imaging (MPI) accounts for up to 50% of all stress MPI studies performed in the U. S. In 2008, the Food and Drug Administration approved regadenoson for stress testing in conjunction with MPI. Regadenoson, unlike adenosine, is a selective A(2A) agonist that is given as an intravenous bolus at a fixed dose, with less undesirable side effects including atrioventricular block and bronchospasm. Unlike adenosine, regadenoson could be used in patients with mild-to-moderate reactive airway disease. This review will summarize the pre-clinical and clinical data on regadenoson, as they specifically relate to its use as a vasodilator stress agent, currently the only approved selective A(2A) agonist. (J Am Coll Cardiol 2009; 54: 1123-30) (C) 2009 by the American College of Cardiology Foundation

【 授权许可】

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