Coronary Calcium Score and Cardiovascular Risk

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

卷:72

Review

Greenland, Philip^1,2  Blaha, Michael J.³  Budoff, Matthew J.⁴  Erbel, Raimund⁵  Watson, Karol E.⁶ 

[1] Northwestern Univ, Feinberg Sch Med, Dept Prevent Med, 680 North Lake Shore Dr,Suite 1400, Chicago, IL 60611 USA

[2] Northwestern Univ, Feinberg Sch Med, Dept Med, Chicago, IL 60611 USA

[3] Johns Hopkins Sch Med, Ciccarone Ctr Prevent Heart Dis, Baltimore, MD USA

[4] LA BioMed, Dept Med, Torrance, CA USA

[5] Univ Clin, Inst Med Informat Biometry & Epidemiol, Essen, Germany

[6] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA

关键词: aspirin;    atherosclerotic cardiovascular disease;    coronary artery calcification;    coronary heart disease;    statins;   

DOI  :  10.1016/j.jacc.2018.05.027

来源: Elsevier

【 摘 要 】

Coronary artery calcium (CAC) is a highly specific feature of coronary atherosclerosis. On the basis of single-center and multicenter clinical and population-based studies with short-term and long-term outcomes data (up to 15-year followup), CAC scoring has emerged as a widely available, consistent, and reproducible means of assessing risk for major cardiovascular outcomes, especially useful in asymptomatic people for planning primary prevention interventions such as statins and aspirin. CAC testing in asymptomatic populations is cost effective across a broad range of baseline risk. This review summarizes evidence concerning CAC, including its pathobiology, modalities for detection, predictive role, use in prediction scoring algorithms, CAC progression, evidence that CAC changes the clinical approach to the patient and patient behavior, novel applications of CAC, future directions in scoring CAC scans, and new CAC guidelines. (C) 2018 by the American College of Cardiology Foundation.

【 授权许可】

Free