Effect of Alirocumab on Lipoprotein(a) and Cardiovascular Risk After Acute Coronary Syndrome

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

卷:75

Article

Bittner, Vera A.¹  Szarek, Michael²  Bhatt, Deepak L.^4,5  Diaz, Rafael⁶  Edelberg, Jay M.⁷  Goodman, Shaun G.^10,11  Hanotin, Corinne¹⁴  Harrington, Robert A.¹⁵  Jukema, J. Wouter¹⁶  Loizeau, Virginie¹⁴  Moryusef, Angele⁷  Pordy, Robert¹⁸  Roe, Matthew T.^19,20  Tsimikas, Sotirios²³  White, Harvey D.²⁵  Zeiher, Andreas M.²⁷  Steg, Gabriel^28,29  Schwartz, Gregory G.²⁴  Aylward, Philip E.³  Drexel, Heinz^30,171  Sinnaeve, Peter^21,22,31  Dilic, Mirza³²  Lopes, Renato D.^1,94,236  Gotcheva, Nina N.³³  Prieto, Juan-Carlos³⁴  Yong, Huo³⁵  Lopez-Jaramillo, Patricio³⁶  Pecin, Ivan³⁷  Reiner, Zeljko³⁸  Ostadal, Petr^39,397  Poulsen, Steen Hvitfeldt⁴⁰  Viigimaa, Margus⁴¹  Nieminen, Markku S.⁴²  Danchin, Nicolas⁴³  Chumburidze, Vakhtang⁴⁴  Marx, Nikolaus⁴⁵  Liberopoulos, Evangelos⁴⁶  Montenegro Valdovinos, Pablo Carlos⁴⁷  Tse, Hung-Fat⁴⁸  Kiss, Robert Gabor⁴⁹  Xavier, Denis⁵⁰  Zahger, Doron²⁶  Valgimigli, Marco⁵¹  Kimura, Takeshi⁵²  Kim, Hyo Soo⁵³  Kim, Sang-Hyun⁵⁴  Erglis, Andrejs⁵⁵  Laucevicius, Aleksandras⁵⁶  Kedev, Sasko⁵⁷  Yusoff, Khalid^58,59  Ramos Lopez, Gabriel Arturo⁶⁰  Alings, Marco⁶¹  Halvorsen, Sigrun^12,13,62  Correa Flores, Roger M.⁶³  Sy, Rody G.⁶⁴  Budaj, Andrzej⁶⁵  Morais, Joao⁶⁶  Dorobantu, Maria⁶⁷  Karpov, Yuri⁶⁸  Ristic, Arsen D.⁶⁹  Chua, Terrance⁷⁰  Murin, Jan⁷¹  Fras, Zlatko^8,9,72,73  Dalby, Anthony J.⁷⁴  Tunon, Jose⁷⁵  de Silva, H. Asita⁷⁶  Hagstrom, Emil⁷⁷  Muller, Christian⁷⁸  Chiang, Chern-En^79,80  Sritara, Piyamitr⁸¹  Guneri, Sema⁸²  Parkhomenko, Alexander⁸³  Ray, Kausik K.⁸⁴  Moriarty, Patrick M.^17,85  Vogel, Robert^24,86  Chaitman, Bernard⁸⁷  Kelsey, Sheryl F.⁸⁸  Olsson, Anders G.⁸⁹  Rouleau, Jean-Lucien⁹⁰  Simoons, Maarten L.⁹¹  Alexander, Karen⁹²  Meloni, Chiara¹⁹  Rosenson, Robert⁹³  Sijbrands, Eric J. G.⁹¹  Alexander, John H.⁹⁴  Armaganijan, Luciana⁹⁵  Bagai, Akshay¹¹  Bahit, Maria Cecilia⁹⁵  Brennan, J. Matthew⁹⁴  Clifton, Shaun⁹⁴  DeVore, Adam D.⁹⁴  Deloatch, Shalonda⁹⁴  Dickey, Sheila⁹⁴  Dombrowski, Keith⁹⁴  Ducrocq, Gregory⁹⁶  Eapen, Zubin⁹⁴  Endsley, Patricia⁹⁴  Eppinger, Arleen⁹⁴  Hess, Connie Ng⁸⁶  Hlatky, Mark A.⁹⁷  Jordan, Joseph Dedrick⁹⁸  Knowles, Joshua W.⁹⁷  Kolls, Bradley J.⁹⁴  Kong, David F.⁹⁴  Leonardi, Sergio⁹⁹  Lillis, Linda⁹⁴  Maron, David J.⁹⁷  Marcus, Jill⁹⁴  Mathews, Robin⁹⁴  Mehta, Rajendra H.⁹⁴  Mentz, Robert J.⁹⁴  Moreira, Humberto Graner⁹⁵  Patel, Chetan B.⁹⁴  Pereira, Sabrina Bernardez⁹⁵  Perkins, Lynn⁹⁴  Povsic, Thomas J.⁹⁴  Puymirat, Etienne¹⁰⁰  Jones, William Schuyler⁹⁴  Shah, Bimal R.⁹⁴  Sherwood, Matthew W.⁹⁴  Stringfellow, Kenya⁹⁴  Sujjavanich, Darin⁹⁴  Toma, Mustafa¹⁰¹  Trotter, Charlene⁹⁴  van Diepen, Sean F. P.¹⁰  Wilson, Matthew D.⁹⁴  Yan, Andrew Tze-Kay¹¹  Schiavi, Lilia B.¹⁰²  Garrido, Marcelo¹⁰³  Alvarisqueta, Andres F.¹⁰⁴  Sassone, Sonia A.¹⁰⁵  Bordonava, Anselmo P.¹⁰⁶  Alves De Lima, Alberto E.¹⁰⁷  Schmidberg, Jorge M.¹⁰⁸  Duronto, Ernesto A.¹⁰⁹  Caruso, Orlando C.¹¹⁰  Novaretto, Leonardo P.¹¹¹  Angel Hominal, Miguel¹¹²  Montana, Oscar R.¹¹³  Caccavo, Alberto¹¹⁴  Gomez Vilamajo, Oscar A.¹¹⁵  Lorenzatti, Alberto J.¹¹⁶  Cartasegna, Luis R.¹¹⁷  Paterlini, Gustavo A.¹¹⁸  Mackinnon, Ignacio J.¹¹⁹  Caime, Guillermo D.¹²⁰  Amuchastegui, Marcos¹²¹  Codutti, Oscar R.¹²²  Jure, Horacio O.¹²³  Bono, Julio O. E.¹²⁴  Hrabar, Adrian D.¹²⁵  Vallejos, Julio A.¹²⁶  Ahuad Guerrero, Rodolfo A.¹²⁷  Novoa, Federico¹²⁸  Patocchi, Cristian A.¹²⁹  Zaidman, Cesar J.¹³⁰  Giuliano, Maria E.¹³¹  Dran, Ricardo D.¹³²  Vico, Marisa L.¹³³  Carnero, Gabriela S.¹³⁴  Guzman, Pablo N.¹³⁵  Medrano Allende, Juan C.¹³⁶  Garcia Brasca, Daniela F.¹³⁷  Bustamante Labarta, Miguel H.¹³⁸  Nani, Sebastian¹³⁹  Blumberg, Eduardo D. S.¹⁴⁰  Colombo, Hugo R.¹⁴¹  Liberman, Alberto¹⁴²  Luciardi, Hector L.¹⁴³  Waisman, Gabriel D.¹⁴⁴  Berli, Mario A.¹⁴⁵  Garcia Duran, Ruben O.¹⁴⁶  Cestari, Horacio G.¹⁴⁷  Luquez, Hugo A.¹⁴⁸  Giordano, Jorge A.¹⁴⁹  Saavedra, Silvia S.¹⁵⁰  Waites, Jonathon H.¹⁵¹  Collins, Nicholas¹⁵²  Soward, Allan¹⁵³  Hii, Chris L. S.¹⁵⁴  Shaw, James¹⁵⁵  Arstall, Margaret A.¹⁵⁶  Horowitz, John¹⁵⁷  Rogers, James F.¹⁵⁸  Colquhoun, David¹⁵⁹  Flores, Romulo E. Oqueli¹⁶⁰  Roberts-Thomson, Philip¹⁶¹  Raffel, Owen¹⁶²  Lehman, Sam J.¹⁶³  Coverdale, Steven G. M.¹⁶⁴  Garrahy, Paul J.¹⁶⁵  Starmer, Gregory¹⁶⁶  Sader, Mark¹⁶⁷  Carroll, Patrick A.¹⁶⁸  Zweiker, Robert¹⁶⁹  Hoppe, Uta¹⁷⁰  Huber, Kurt¹⁷²  Berger, Rudolf¹⁷³  Weidinger, Franz¹⁷⁴  Faes, Dirk¹⁷⁵  Hermans, Kurt¹⁷⁶  Pirenne, Bruno¹⁷⁷  Leone, Attilio¹⁷⁸  Hoffer, Etienne¹⁷⁹  Vrolix, Mathias C. M.¹⁸⁰  De Wolf, Luc¹⁸¹  Wollaert, Bart¹⁸²  Castadot, Marc¹⁸³  Dujardin, Karl¹⁸⁴  Beauloye, Christophe¹⁸⁵  Vervoort, Geert¹⁸⁶  Striekwold, Harry¹⁸⁷  Convens, Carl¹⁸⁸  Roosen, John¹⁸⁹  Barbato, Emanuele¹⁹⁰  Claeys, Marc¹⁹¹  Cools, Frank¹⁹²  Terzic, Ibrahim¹⁹³  Barakovic, Fahir¹⁹⁴  Midzic, Zlatko¹⁹⁵  Pojskic, Belma¹⁹⁶  Fazlibegovic, Emir¹⁹⁷  Durak-Nalbantic, Azra³²  Vulic, Dusko¹⁹⁸  Muslibegovic, Adis¹⁹⁹  Reis, Gilmar²⁰⁰  Sousa, Luciano²⁰¹  Nicolau, Jose C.²⁰²  Giorgeto, Flavio E.²⁰³  Silva, Ricardo P.²⁰⁴  Maia, Lilia Nigro²⁰⁵  Rech, Rafael²⁰⁶  Rossi, Paulo R. F.²⁰⁷  Cerqueira, Maria Jose A. G.²⁰⁸  Duda, Norberto²⁰⁹  Kalil, Renato²¹⁰  Kormann, Adrian²¹¹  Abrantes, Jose Antonio M.²¹²  Pimentel Filho, Pedro²¹³  Soggia, Ana Priscila²¹⁴  de Santos, Mayler O. N.²¹⁵  Neuenschwander, Fernando²¹⁶  Bodanese, Luiz C.²¹⁷  Michalaros, Yorghos L.^218,253  Eliaschewitz, Freddy G.²¹⁹  Vidotti, Maria H.²²⁰  Leaes, Paulo E.²²¹  Botelho, Roberto V.²²²  Kaiser, Sergio²²³  Fernandes Manenti, Euler Roberto F.²²⁴  Precoma, Dalton B.²²⁵  Moura Jorge, Jose C.²²⁶  Silva, Pedro G. M. de B.²²⁷  Silveira, Jose A.²²⁸  Saporito, Wladimir^229,237  Marin Neto, Jose A.²³⁰  Feitosa, Gilson S.²³¹  Ritt, Luiz Eduardo F.²³¹  de Souza, Juliana A.²³²  Costa, Fernando²³³  Souza, Weimar K. S. B.²³⁴  Reis, Helder J. L.²³⁵  Machado, Leandro²³⁷  Aidar Ayoub, Jose Carlos²³⁸  Todorov, Georgi V.²³⁹  Nikolov, Fedya P.²⁴⁰  Velcheva, Elena S.²⁴¹  Tzekova, Maria L.²⁴²  Benov, Haralambi O.²⁴³  Petranov, Stanislav L.²⁴⁴  Tumbev, Haralin S.²⁴⁵  Shehova-Yankova, Nina S.²⁴⁶  Markov, Dimitar T.²⁴⁷  Raev, Dimitar H.²⁴⁸  Mollov, Mihail N.²⁴⁹  Kichukov, Kostadin N.²⁵⁰  Ilieva-Pandeva, Katya A.²⁵¹  Ivanova, Raya²⁵²  Mincheva, Valentina M.²⁵³  Lazov, Petar V.²⁵⁴  Dimov, Bojidar I.²⁵⁵  Senaratne, Manohara²⁵⁶  Stone, James²⁵⁷  Pearce, Stephen²⁵⁸  Dion, Danielle²⁵⁹  Savard, Daniel²⁶⁰  Pesant, Yves²⁶¹  Pandey, Amritanshu²⁶²  Robinson, Simon²⁶³  Gosselin, Gilbert²⁶⁴  Vizel, Saul²⁶⁵  Hoag, Gordon²⁶⁶  Bourgeois, Ronald²⁶⁷  Morisset, Anne²⁶⁸  Sabbah, Eric²⁶⁹  Sussex, Bruce²⁷⁰  Kouz, Simon²⁷¹  MacDonald, Paul²⁷²  Diaz, Ariel²⁷³  Michaud, Nicolas²⁷⁴  Fell, David²⁷⁵  Leung, Raymond²⁷⁶  Vuurmans, Tycho²⁷⁷  Lai, Christopher²⁷⁸  Nigro, Frank²⁷⁸  Davies, Richard²⁷⁹  Nogareda, Gustavo²⁸⁰  Vijayaraghavan, Ram²⁸¹  Ducas, John²⁸²  Lepage, Serge²⁸³  Mehta, Shamir²⁸⁴  Cha, James²⁸⁵  Dupuis, Robert²⁸⁶  Fong, Peter²⁸⁷  Rodes-Cabau, Josep²⁸⁸  Fadlallah, Hussein²⁸⁹  Cleveland, David²⁹⁰  Huynh, Thao²⁹¹  Bata, Iqbal²⁹²  Hameed, Adnan²⁹³  Pincetti, Cristian²⁹⁴  Potthoff, Sergio²⁹⁵  Acevedo, Monica²⁹⁶  Aguirre, Arnoldo²⁹⁷  Vejar, Margarita²⁹⁸  Yanez, Mario²⁹⁹  Araneda, Guillermo³⁰⁰  Fernandez, Mauricio³⁰¹  Perez, Luis³⁰²  Varleta, Paola³⁰³  Florenzano, Fernando³⁰⁴  Huidobro, Laura³⁰⁵  Raffo, Carlos A.³⁰⁶  Olivares, Claudia³⁰⁷  Chen, Jiyan³⁰⁸  Dong, Yugang³⁰⁹  Huang, Weijian³¹⁰  Wang, Jianzhong³¹¹  Huang, Shi'An³¹²  Yao, Zhuhua³¹³  Cui, Lan³¹⁴  Lin, Wenhua³¹⁵  Sun, Yuemin³¹⁶  Wang, Jingfeng³¹⁷  Li, Jianping³¹⁸  Zhang, Xuelian³¹⁹  Zhu, Hong³²⁰  Chen, Dandan³²¹  Huang, Lan³²²  Dong, Shaohong³²³  Su, Guohai³²⁴  Xu, Biao³²⁵  Su, Xi³²⁶  Cheng, Xiaoshu³²⁷  Lin, Jinxiu³²⁸  Zong, Wenxia³²⁹  Li, Huanming³³⁰  Feng, Yi³³¹  Xu, Dingli³³²  Yang, Xinchun³³³  Ke, Yuannan³³⁴  Lin, Xuefeng³³⁵  Zhang, Zheng³³⁶  Zheng, Zeqi³³⁷  Luo, Zhurong³³⁸  Chen, Yundai³³⁹  Ding, Chunhua³⁴⁰  Zheng, Yang³⁴¹  Li, Xiaodong³⁴²  Peng, Daoquan³⁴³  Li, Ying³⁴⁴  Wei, Meng³⁴⁵  Liu, Shaowen³⁴⁶  Yu, Yihua³⁴⁷  Qu, Baiming³⁴⁸  Jiang, Weihong³⁴⁹  Zhou, Yujie³⁵⁰  Zhao, Xingsheng³⁵¹  Yuan, Zuyi³⁵²  Guo, Ying³⁵³  Xu, Xiping³⁵⁴  Shi, Xubo³⁵⁵  Ge, Junbo³⁵⁶  Fu, Guosheng³⁵⁷  Bai, Feng³⁵⁸  Fang, Weiyi³⁵⁹  Shou, Xiling³⁶⁰  Yang, Xiangjun^360,361  Wang, Jian'An³⁶²  Jaramillo, Nicolas³⁶³  Vallejo, Gregorio Sanchez³⁶⁴  Botia, Diana C. Luna³⁶⁵  Lopez, Rodrigo Botero³⁶⁶  De Salazar, Dora I. Molina³⁶⁷  Bonfanti, Alberto J. Cadena³⁶⁸  Higuera, Juan Diego³⁶⁹  Silva, Sandra I. Barrera³⁷⁰  Lozada, Henry J. Garcia³⁷¹  Arroyo, Julian A. Coronel³⁷²  Mendoza, Jose L. Accini³⁷³  Ruiz, Ricardo L. Fernandez³⁷⁴  Fernandez, Angela M.³⁷⁵  Jatin, Fernando G. Manzur³⁷⁶  Herazo, Aristides Sotomayor³⁷⁷  Parada, Jeffrey Castellanos³⁷⁸  Triana, Miguel A. Urina³⁷⁹  Spinar, Jindrich³⁸⁰  Horak, David³⁸¹  Stasek, Josef³⁸²  Alan, David³⁸³  Machova, Vilma³⁸⁴  Linhart, Ales³⁸⁵  Novotny, Vojtech³⁸⁶  Kaucak, Vladimir³⁸⁷  Rokyta, Richard³⁸⁸  Naplava, Robert³⁸⁹  Coufal, Zdenek³⁹⁰  Adamkova, Vera³⁹¹  Podpera, Ivo³⁹²  Zizka, Jiri³⁹³  Motovska, Zuzana³⁹⁴  Marusincova, Ivana³⁹⁵  Svab, Premysl³⁹⁶  Heinc, Petr³⁹⁸  Kuchar, Jiri³⁹⁹  Povolny, Petr⁴⁰⁰  Raungaard, Bent⁴⁰¹  Clemmensen, Peter⁴⁰²  Bang, Lia E.⁴⁰²  May, Ole⁴⁰³  Bottcher, Morten⁴⁰³  Hove, Jens D.⁴⁰⁴  Frost, Lars⁴⁰⁵  Gislason, Gunnar⁴⁰⁶  Larsen, John⁴⁰⁷  Johansen, Peter Betton⁴⁰⁸  Hald, Flemming⁴⁰⁸  Jeppesen, Jorgen⁴⁰⁹  Nielsen, Tonny⁴¹⁰  Kristensen, Kjeld S.⁴¹¹  Walichiewicz, Piotr Maria⁴¹¹  Lomholdt, Jens D.⁴¹²  Klausen, Ib C.⁴¹³  Nielsen, Peter Kaiser⁴¹⁴  Davidsen, Flemming⁴¹⁵  Videbaek, Lars⁴¹⁶  Soots, Mai⁴¹⁷  Vahula, Veiko⁴¹⁸  Hedman, Anu⁴¹⁹  Soopold, sllar⁴²⁰  Martsin, Kaja⁴²¹  Taskinen, Marja-Riitta^422,423  Porthan, Kimmo^422,423  Airaksinen, Juhani K.⁴²⁴  Juonala, Markus⁴²⁴  Kiviniemi, Tuomas⁴²⁴  Vikman, Saila⁴²⁵  Posio, Pirjo⁴²⁵  Taurio, Jyrki⁴²⁶  Huikuri, Heikki^427,428  Kaikkonen, Kari^427,428  Coste, Pierre⁴²⁹  Ferrari, Emile⁴³⁰  Morel, Olivier⁴³¹  Montalescot, Gilles⁴³²  Barone-Rochette, Gilles⁴³³  Mansourati, Jacques⁴³⁴  Cottin, Yves⁴³⁵  Steg, Philippe Gabriel⁴³⁶  Leclercq, Florence⁴³⁷  Belhassane, Abdelkader⁴³⁸  Delarche, Nicolas⁴³⁹  Boccara, Franck⁴⁴⁰  Paganelli, Franck⁴⁴¹  Clerc, Jerome⁴⁴²  Schiele, Francois⁴⁴³  Aboyans, Victor⁴⁴⁴  Probst, Vincent⁴⁴⁵  Berland, Jacques⁴⁴⁶  Lefevre, Thierry⁴⁴⁷  Simic, Dragan⁶⁹  Asanin, Milika R.⁶⁹ 

[1] Univ Alabama Birmingham, Div Cardiovasc Dis, Birmingham, AL USA

[2] SUNY, Downstate Sch Publ Hlth, Brooklyn, NY USA

[3] Flinders Univ & Med Ctr, South Australian Hlth & Med Res Inst, Adelaide, SA, Australia

[4] Brigham & Womens Hosp, Heart & Vasc Ctr, 75 Francis St, Boston, MA 02115 USA

[5] Harvard Med Sch, Boston, MA 02115 USA

[6] Inst Cardiovasc Rosario, Estudios Cardiol Latinoamer, Rosario, Argentina

[7] Sanofi, Bridgewater, MA USA

[8] Univ Med Ctr Ljubljana, Prevent Cardiol Unit, Div Med, Dept Vasc Med, Ljubljana, Slovenia

[9] Univ Ljubljana, Med Fac, Ljubljana, Slovenia

[10] Univ Alberta, Canadian VIGOUR Ctr, Edmonton, AB, Canada

[11] Univ Toronto, St Michaels Hosp, Toronto, ON, Canada

[12] Oslo Univ Hosp, Dept Cardiol, Oslo, Norway

[13] Univ Oslo, Oslo, Norway

[14] Sanofi, Paris, France

[15] Stanford Univ, Dept Med, Stanford Ctr Clin Res, Stanford, CA 94305 USA

[16] Leiden Univ, Med Ctr, Dept Cardiol, Leiden, Netherlands

[17] Univ Kansas, Med Ctr, Div Clin Pharmacol, Kansas City, KS 66103 USA

[18] Regeneron Pharmaceut Inc, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA

[19] Duke Univ, Med Ctr, Duke Clin Res Inst, Durham, NC USA

[20] Duke Univ, Sch Med, Dept Med, Div Cardiol, Durham, NC 27706 USA

[21] Univ Hosp Leuven, Dept Cardiovasc Med, Leuven, Belgium

[22] Univ Leuven, Leuven, Belgium

[23] Univ Calif San Diego, Div Cardiovasc Med, La Jolla, CA 92093 USA

[24] Univ Colorado, Div Cardiol, Sch Med, Aurora, CO USA

[25] Auckland City Hosp, Green Lane Cardiovasc Serv, Auckland, New Zealand

[26] Ben Gurion Univ Negev, Soroka Univ Med Ctr, Fac Hlth Sci, Beer Sheva, Israel

[27] Goethe Univ, Dept Med 3, Frankfurt, Germany

[28] Univ Paris, Hop Bichat, AP HP, FACT,INSERM,U1148, Paris, France

[29] Imperial Coll, Natl Heart & Lung Inst, Royal Brompton Hosp, London, England

[30] Landeskrankenhaus Feldkirch, Feldkirch, Austria

[31] UZ Leuven, Leuven, Belgium

[32] Univ Clin Ctr Sarajevo, Sarajevo, Bosnia & Herceg

[33] MHAT Natl Cardiol Hosp EAD, Sofia, Bulgaria

[34] Hosp Clin Univ Chile, Santiago, Chile

[35] Peking Univ First Hosp, Beijing, Peoples R China

[36] Fdn Oftalmol Santander FOSCAL, Floridablanca, Colombia

[37] Univ Zagreb, Univ Hosp Ctr Zagreb, Zagreb Sch Med, Zagreb, Croatia

[38] Univ Zagreb, Univ Hosp Ctr Zagreb, Sch Med, Zagreb, Croatia

[39] Na Homolce Hosp, Prague, Czech Republic

[40] Aarhus Univ Hosp Skejby, Aarhus N, Denmark

[41] SA Pohja Eesti Reg Haigla, Tallinn, Estonia

[42] HUCH, Div Cardiol, Heart & Lung Ctr, Helsinki, Finland

[43] FACT, Hop Europeen Georges Pompidou, Paris, France

[44] Chapidze Emergency Cardiol Ctr, Tbilisi, Georgia

[45] Univ Klinikum Aachen, Aachen, Germany

[46] Univ Gen Hosp Ioannina, Ioannina, Greece

[47] Clin Privada, Unidad Diagnost Cardiol, Guatemala City, Guatemala

[48] Univ Hong Kong, Queen Mary Hosp, Hong Kong, Peoples R China

[49] Magyar Honvedseg Egeszsegugyi Kozpont, Budapest, Hungary

[50] St Johns Med Coll, Bangalore, Karnataka, India

[51] Univ Ferrara, Unit Operat Cardiol, Ferrara, Italy

[52] Kyoto Univ, Grad Sch Med, Kyoto, Kyoto, Japan

[53] Seoul Natl Univ Hosp, Seoul, South Korea

[54] SMG Seoul Natl Univ, Boramae Med Ctr, Seoul, South Korea

[55] Pauls Stradins Clin Univ Hosp, Riga, Latvia

[56] Vilnius Univ Hosp, Santaros Klin, Vilnius, Lithuania

[57] Univ Clin Cardiol, Skopje, North Macedonia

[58] Univ Teknol MARA UiTM Selayang Campus, Batu Caves, Malaysia

[59] UCSI Univ, Kuala Lumpur, Malaysia

[60] Med Off, Guadalajara, Jalisco, Mexico

[61] Amphia Ziekenhuis Molengracht, Breda, Netherlands

[62] Oslo Univ Sykehus HF, Oslo, Norway

[63] Hosp Nacl IV Alberto Sabogal Sologuren, Callao, Peru

[64] Cardinal Santos Med Ctr, San Juan, Philippines

[65] Grochowski Hosp, Postgrad Med Sch, Warsaw, Poland

[66] Ctr Hosp Leiria Pombal, Leiria, Portugal

[67] Clin Emergency Hosp Bucharest, Bucharest, Romania

[68] Russian Cardiol Sci Prod Complex, Moscow, Russia

[69] Clin Ctr Serbia, Belgrade, Serbia

[70] Natl Heart Ctr, Singapore, Singapore

[71] Univ Nemocn Bratislava, Interna Klin 1, Bratislava, Slovakia

[72] Univ Med Ctr Ljubljana, Div Med, Dept Vasc Med, Prevent Cardiol Unit, Ljubljana, Slovenia

[73] Univ Ljubljana, Fac Med, Ljubljana, Slovenia

[74] Milpark Hosp, Johannesburg, South Africa

[75] Fdn Jimenez Diaz, Madrid, Spain

[76] Univ Kelaniya, Clin Trials Unit, Colombo, Sri Lanka

[77] Uppsala Univ Hosp, Uppsala, Sweden

[78] Univ Spital Basel, Basel, Switzerland

[79] Taipei Vet Gen Hosp, Gen Clin Res Ctr, Taipei, Taiwan

[80] Natl Yang Ming Univ, Taipei, Taiwan

[81] Ramathibodi Hosp, Bangkok, Thailand

[82] Dokuz Eylul Univ, Tip Fak, Izmir, Turkey

[83] MD Strazhesko Inst Cardiol AMS Ukraine, Kiev, Ukraine

[84] Imperial Coll London, London, England

[85] Univ Kansas, Med Ctr, Clin Pharmacol, Kansas City, KS 66103 USA

[86] Univ Colorado Denver, Denver, CO USA

[87] St Louis Univ, St Louis Univ Ctr Hlth Outcomes Res, St Louis, MO USA

[88] Univ Pittsburgh, Grad Sch Publ Hlth, Pittsburgh, PA 15260 USA

[89] Linkoping Univ, Dept Med & Hlth, Linkoping, Sweden

[90] Univ Montreal, Inst Cardiol, Montreal, PQ, Canada

[91] Erasmus MC, Rotterdam, Netherlands

[92] Duke Univ, Duke Clin Res Inst, Durham, NC USA

[93] Mt Sinai Sch Med, New York, NY USA

[94] Duke Univ, Durham, NC USA

[95] Brazilian Clin Res Inst, Sao Paulo, Brazil

[96] Hop Bichat Claude Bernard, AP HP, Paris, France

[97] Stanford Univ, Stanford, CA 94305 USA

[98] Univ N Carolina, Chapel Hill, NC USA

[99] Fdn IRCCS Policlin S Matteo, Pavia, Italy

[100] Hop Europeen Georges Pompidou, Paris, France

[101] Univ British Columbia, St Pauls Hosp, Vancouver, BC, Canada

[102] Clin Del Prado, Cordoba, Cordoba, Argentina

[103] Clin Privada Prov, Merlo, Buenos Aires, Argentina

[104] Ctr Invest Med Mar del Plata, Mar Del Plata, Buenos Aires, Argentina

[105] Consultorios Asoc Endocrinol & Inv Clin Aplicad, Caba, Buenos Aires, Argentina

[106] Clin FUSAVIM Privada, Villa Maria, Cordoba, Argentina

[107] Inst Cardiovasc Buenos Aires, Buenos Aires, Buenos Aires, Argentina

[108] Inst Med Aguero, Moron, Buenos Aires, Argentina

[109] Fdn Favaloro Docencia & Invest Med, Caba, Buenos Aires, Argentina

[110] Hosp Cent Mendoza, Mendoza, Mendoza, Argentina

[111] Sanatorio Santa Rosa, Santa Rosa, La Pampa, Argentina

[112] Ctr Invest Clin Litoral, Santa Fe, Santa Fe, Argentina

[113] Dim Clin Privada, Ramos Mejia, Buenos Aires, Argentina

[114] Clin Coronel Suarez, Coronel Suarez, Buenos Aires, Argentina

[115] Sanatorio San Martin SA, Venado Tuerto, Santa Fe, Argentina

[116] Inst Med DAMIC, Cordoba, Cordoba, Argentina

[117] Hosp Italiano La Plata, La Plata, Buenos Aires, Argentina

[118] Invest Clin Tucuman, San Miguel De Tucuman, Tucuman, Argentina

[119] Inst Invest Clin, Mar Del Plata, Buenos Aires, Argentina

[120] Inst Diagnost La Plata, La Plata, Buenos Aires, Argentina

[121] Hosp Privado Ctr Med Cordoba, Cordoba, Cordoba, Argentina

[122] Cordis Inst Corazon, Resistencia, Chaco, Argentina

[123] Clin Chutro SRL, Cordoba, Cordoba, Argentina

[124] Sanat Allende, Cordoba, Cordoba, Argentina

[125] Inst Invest Clin Quilmes, Quilmes, Buenos Aires, Argentina

[126] Inst Cardiol Corrientes, Corrientes, Corrientes, Argentina

[127] Corp Med San Martin, San Martin, Buenos Aires, Argentina

[128] Grp Med Alem, San Isidro, Buenos Aires, Argentina

[129] Hosp Reg Espanol Bahia Blanca, Bahia Blanca, Buenos Aires, Argentina

[130] Ctr Invest & Prevenc Cardiovasc, Caba, Buenos Aires, Argentina

[131] Fdn Estudios Clin, Inst Med, Rosario, Santa Fe, Argentina

[132] Sanat Mariano Pelliza, Olivos, Buenos Aires, Argentina

[133] Inst Invest Clin Zarate, Zarate, Buenos Aires, Argentina

[134] IMEP, Ciudadela, Buenos Aires, Argentina

[135] Sanat San Francisco, Santiago Del Estero, Santiago Estero, Argentina

[136] Clin & Maternidad Suizo Argentina, Caba, Buenos Aires, Argentina

[137] Hosp Italiano, Cordoba, Cordoba, Argentina

[138] Ctr Med Lebensohn, Junin, Buenos Aires, Argentina

[139] Clin Olivos, Olivos, Buenos Aires, Argentina

[140] Medeos, Caba, Buenos Aires, Argentina

[141] Clin Colombo, Cordoba, Cordoba, Argentina

[142] Inst Privado Invest Clin Cordoba, Cordoba, Cordoba, Argentina

[143] Ctr Modelo Cardiol, San Miguel De Tucuman, Tucuman, Argentina

[144] Hosp Italiano Buenos Aires, Buenos Aires, Buenos Aires, Argentina

[145] Hosp Prov Dr Jose Maria Cullen, Santa Fe, Santa Fe, Argentina

[146] Inst Invest Clin San Nicolas, San Nicolas, Buenos Aires, Argentina

[147] Sanatorio Guemes, Caba, Buenos Aires, Argentina

[148] Ctr Med Luquez, Cordoba, Cordoba, Argentina

[149] Clin Inst Med Adrogue, Almirante Brown, Buenos Aires, Argentina

[150] Sanat Parque SA, Salta, Salta, Argentina

[151] Coffs Harbour Hlth Campus, Coffs Harbour, NSW, Australia

[152] John Hunter Hosp, New Lambton Hts, NSW, Australia

[153] Mildura Cardiol, Mildura, Vic, Australia

[154] Calvary Clin, Bruce, ACT, Australia

[155] Alfred Hosp, Prahran, Vic, Australia

[156] Northern Cardiol & Specialist Clin, Elizabeth Vale, SA, Australia

[157] Queen Elizabeth Hosp, Woodville, SA, Australia

[158] Gosford Hosp, Gosford, NSW, Australia

[159] Wesley Med Ctr, Auchenflower, Qld, Australia

[160] Ballarat Hlth Serv, Ballarat, Vic, Australia

[161] Royal Hobart Hosp, Hobart, Tas, Australia

[162] Prince Charles Hosp, Chermside, Qld, Australia

[163] Adelaide Med Res, Ashford, SA, Australia

[164] Nambour Gen Hosp, Nambour, Qld, Australia

[165] Princess Alexandra Hosp, Woolloongabba, Qld, Australia

[166] Cairns Hosp, Cairns, Qld, Australia

[167] St George Hosp, Kogarah, NSW, Australia

[168] Redcliffe Hosp, Redcliffe, Qld, Australia

[169] Univ Klinikum Graz, Graz, Austria

[170] Univ Klinikum Salzburg, Salzburg, Austria

[171] Vorarlberg Inst Vaskulare Forsch VIVIT, Feldkirch, Austria

[172] Wilhelminenspital Stadt Wien, Vienna, Austria

[173] KH Barmherzigen Bruder Eisenstadt, Kardiol & Nephrol, Eisenstadt, Austria

[174] Krankenanstalt Rudolfstiftung Stadt Wien, Vienna, Austria

[175] Mariaziekenhuis Vzw, Overpelt, Belgium

[176] AZ St Lucas, Ghent, Belgium

[177] Clin St Pierre, Ottignies, Belgium

[178] CHU Tivoli, La Louviere, Belgium

[179] CHR Citadelle, Liege, Belgium

[180] ZOL, Genk, Belgium

[181] Private Practice, Tienen, Belgium

[182] ZNA Stuivenberg, Antwerp, Belgium

[183] Clin St Jean, Brussels, Belgium

[184] AZ Delta, Roeselare, Belgium

[185] UCL St Luc, Brussels, Belgium

[186] AZ St Maarten, Mechelen, Belgium

[187] Heilig Hart Ziekenhuis, Mol, Belgium

[188] ZNA Middelheim, Antwerp, Belgium

[189] Imelda Hosp, Bonheiden, Belgium

[190] OL Vrouwziekenhuis Campus Aalst, Aalst, Belgium

[191] UZ Antwerpen, Edegem, Belgium

[192] AZ Klina, Brasschaat, Belgium

[193] Heart Ctr BH, Tuzla, Bosnia & Herceg

[194] Univ Med Ctr Tuzla, Tuzla, Bosnia & Herceg

[195] Cantonal Hosp Dr Irfan Ljubijank Bihac, Bihac, Bosnia & Herceg

[196] Cantonal Hosp Zenica, Zenica, Bosnia & Herceg

[197] Univ Clin Hosp Mostar, Mostar, Bosnia & Herceg

[198] Clin Ctr Banja Luka, Banja Luka, Bosnia & Herceg

[199] Reg Med Ctr Dr Safet Mujic, Mostar, Bosnia & Herceg

[200] CARDRESEARCH Cardiol Assistencial & Pesquisa, Belo Horizonte, MG, Brazil

[201] Hosp Coracao Brasil, Brasilia, DF, Brazil

[202] INCOR Inst Coracao, Sao Paulo, Brazil

[203] Hosp Sao Francisco De Assis, Belo Horizonte, MG, Brazil

[204] Hosp Univ Walter Cantidio, Fortaleza, Ceara, Brazil

[205] Hosp Base Sao Jose Rio Preto, Sao Paulo, Brazil

[206] Hosp Univ Ulbra, Canoas, Brazil

[207] Hosp Evangelico Curitiba, Curitiba, Parana, Brazil

[208] Inst Ensino Pesquisa Clin Ceara Ltda, Fortaleza, Ceara, Brazil

[209] Hosp Sao Vicente De Paulo, Passo Fundo, RS, Brazil

[210] Inst Cardiol Do Rio Grande Do Sul, Porto Alegre, RS, Brazil

[211] Hosp Santa Isabel, Soc Div Providencia, Blumenau, Santa Catarina, Brazil

[212] Santa Casa Misericordia Pelotas, Pelotas, RS, Brazil

[213] Hosp Nossa Senhora Conceicao, Porto Alegre, RS, Brazil

[214] Soc Beneficiente Senhoras Hosp Sirio Libanes, Sao Paulo, Brazil

[215] Ctr Cardiol & Radiol Intervencionista LTDA, Aparecida Goiania, Brazil

[216] Hosp Vera Cruz NUPEC, Belo Horizonte, MG, Brazil

[217] Hosp Sao Lucas PUCRS, Porto Alegre, RS, Brazil

[218] Inst Ensino Consultoria & Pesquisa Clin LTDA ME, Belo Horizonte, MG, Brazil

[219] CPCLIN, Sao Paulo, Brazil

[220] Clin LOEMA, Campinas, Brazil

[221] Santa Casa Porto Alegre, Porto Alegre, RS, Brazil

[222] Inst Coracao Triangulo, Uberlandia, MG, Brazil

[223] CCBR Brasil, Rio De Janeiro, Brazil

[224] IMV Inst Med Vasc Hosp Mae de Deus, Porto Alegre, RS, Brazil

[225] Soc Hosp Angelina Caron, Campina Grande Do Sul, Parana, Brazil

[226] Santa Casa Curitiba, Curitiba, Parana, Brazil

[227] Esho Empresa Serv Hosp SA, Sao Paulo, SP, Brazil

[228] Fac Med ABC CEMEC, Sao Bernardo Do Campo, SP, Brazil

[229] Inst Molestias Cardiovasc Tatui IMC, Tatui, SP, Brazil

[230] HCFMRP, Riberao, Preto, Brazil

[231] Hosp Santa Izabel Santa Casa Misericordia Bahia, Salvador, BA, Brazil

[232] Ctr Cardiol Clin & Pesquisa Dra Juliana Souz, Brasilia, DF, Brazil

[233] FGM Clin Paulista Doencas Cardiovasc, Sao Paulo, Brazil

[234] Barroso & Sebba Ltda, Goiania, Go, Brazil

[235] Hosp Clin Gaspar Vianna, Belem, Para, Brazil

[236] Univ Fed Sao Paulo UNIFESP EPM, Sao Paulo, Brazil

[237] Hosp Estadual Mario Covas, Santo Andre, Brazil

[238] Inst Molestias Cardiovasc IMC Sao Jose do Rio Pre, Sao Jose Do Rio Preto, Brazil

[239] 2 MHAT, Sofia, Bulgaria

[240] Univ Multiprofile Hosp Act Treatment Sveti Georgi, Plovdiv, Bulgaria

[241] Specialized Hosp Act Treatment Cardiol, Pleven, Bulgaria

[242] UMHAT Dr Georgi Stranski, Pleven, Bulgaria

[243] Multiprof Distr Hosp Act Treatment Dr St Cherkezo, Veliko Tarnovo, Bulgaria

[244] Multiprofile Hosp Act Treatment Burgas AD, Burgas, Bulgaria

[245] Specialized Hosp Act Cardio Treatment Cardiolife, Varna, Bulgaria

[246] MHAT Bratan Shukerov AD, Cardio Dept Inrtens Unite, Smoljan, Bulgaria

[247] UMHAT Tzaritza Yoanna ISUL EAD, Sofia, Bulgaria

[248] MHAT Sveti Vrach EOOD, Sandanski, Bulgaria

[249] First Multiprofile Hosp Act Treatment Sofia EAD, Sofia, Bulgaria

[250] MHAT Lyulin EAD Dept Internal Dis, Sofia, Bulgaria

[251] MHAT Blagoevgrad AD, Blagoevgrad, Bulgaria

[252] UMHAT Alexandrovska EAD, Sofia, Bulgaria

[253] NMT Hosp Tsar Boris III, Sofia, Bulgaria

[254] Multiprofile Hosp Act Treatment Pazardzhik AD, Pazardzhik, Bulgaria

[255] Fifth MHAT Sofia EAD, Sofia, Bulgaria

[256] Dr MPJ Senaratne Professional Corp, Edmonton, AB, Canada

[257] TotalCardiology, Calgary, AB, Canada

[258] Surrey Mem Hosp, Surrey, BC, Canada

[259] Ctr Hosp Beauce Etchemin, St Georges De Beauce, PQ, Canada

[260] CardioVasc HR, St Jean, PQ, Canada

[261] St Jerome Med Res Inc, St Jerome, PQ, Canada

[262] Cambridge Cardiac Care Ctr, Cambridge, ON, Canada

[263] Victoria Heart Inst Fdn, Victoria, BC, Canada

[264] Ctr Hosp Pierre Le Gardeur, Terrebonne, PQ, Canada

[265] Vizel Cardiac Res, Cambridge, ON, Canada

[266] Discovery Clin Serv, Victoria, BC, Canada

[267] GA Res Associates Ltd, Moncton, NB, Canada

[268] Ctr Sante & Serv Sociaux Haute Yamaska, Granby, PQ, Canada

[269] Ctr Depistage & Rech Cardiovasc Rive Sud, Longueuil, PQ, Canada

[270] Gen Hosp Hlth Sci Ctr, St John, NF, Canada

[271] Ctr Hosp Reg Lanaudiere, Joliette, PQ, Canada

[272] Cape Breton Reg Hosp, Sydney, NS, Canada

[273] Ctr Hosp Reg Trois Rivieres, Trois Rivieres, PQ, Canada

[274] Clin Cardiol Levis, Levis, PQ, Canada

[275] Newmarket Cardiol Res Grp, Newmarket, ON, Canada

[276] Royal Alexandra Hosp, Edmonton, AB, Canada

[277] Royal Columbian Hosp, New Westminster, BC, Canada

[278] Thunder Bay Reg Hlth Sci Ctr, Thunder Bay, ON, Canada

[279] Ottawa Heart Inst, Ottawa, ON, Canada

[280] Red Deer Reg Hosp Ctr, Red Deer, AB, Canada

[281] Scarborough Cardiol Res, Scarborough, ON, Canada

[282] St Boniface Gen Hosp, Winnipeg, MB, Canada

[283] Hotel Dieu Ctr Hosp Univ Sherbrooke, Sherbrooke, PQ, Canada

[284] Hamilton Gen Hosp, Hamilton, ON, Canada

[285] Lakeridge Hlth Oshawa, Oshawa, ON, Canada

[286] Ctr Sante & Serv Sociaux Reg Thetford Rech, Thetford Mines, PQ, Canada

[287] St Johns Hosp, St John, NB, Canada

[288] Laval Hosp, Quebec Heart Inst, Quebec City, PQ, Canada

[289] Rech GCP Res, Montreal, PQ, Canada

[290] Penticton Reg Hosp, Penticton, BC, Canada

[291] Montreal Gen Hosp, Montreal, PQ, Canada

[292] Queen Elizabeth 2 Hlth Sci Ctr, Halifax, NS, Canada

[293] Med Profess Corp, St Catharines, ON, Canada

[294] Ctr Invest Clin Cics, Temuco, Chile

[295] Corp Beneficencia Osorno, Osorno, Chile

[296] Univ Catolica, Ctr Invest Clin, Santiago, Chile

[297] Hosp Barros Luco, Santiago, Chile

[298] Hosp Salvador, Santiago, Chile

[299] Hosp Naval Almirante Nef Vina del Mar, Vina Del Mar, Chile

[300] Hosp Clin Magallanes, Punta Arenas, Chile

[301] Clin Alemana Santiago, Santiago, Chile

[302] Hosp Clin Reg Dr Guillermo Grant Benavente, Concepcion, Chile

[303] Psicomed Clin & Res Grp, Santiago, Chile

[304] Biomed Res Grp, Santiago, Chile

[305] Clin Univ Catolica Maule, Talca, Chile

[306] Estudios Clin V Reg Ltda, Vina Del Mar, Chile

[307] Hosp & CRS El Pino, Santiago, Chile

[308] Guangdong Gen Hosp, Guangzhou, Guangdong, Peoples R China

[309] Sun Yat Sen Univ, Affiliated Hosp 1, Guangzhou, Guangdong, Peoples R China

[310] Wenzhou Med Univ, Affiliated Hosp 1, Wenzhou, Peoples R China

[311] Siping Cent Peoples Hosp, Siping, Peoples R China

[312] Guangdong Med Univ, Affiliated Hosp, Zhanjiang, Peoples R China

[313] Tianjin Union Med Ctr, Tianjin, Peoples R China

[314] Yanbian Univ Hosp, Yanji, Peoples R China

[315] TEDA Int Cardiovasc Hosp, Tianjin, Peoples R China

[316] Tianjin Med Univ, Gen Hosp, Tianjin, Peoples R China

[317] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Guangzhou, Guangdong, Peoples R China

[318] Peking Univ, Hosp 1, Beijing, Peoples R China

[319] Jilin Prov Peoples Hosp, Changchun, Jilin, Peoples R China

[320] Xuzhou Med Coll, Affiliated Hosp, Xuzhou, Jiangsu, Peoples R China

[321] Guizhou Prov Peoples Hosp, Guiyang, Guizhou, Peoples R China

[322] Third Mil Med Univ, Xinqiao Hosp, Chongqing, Peoples R China

[323] Shenzhen Peoples Hosp, Shenzhen, Peoples R China

[324] Shandong Univ, Jinan Cent Hosp Affiliated, Jinan, Shandong, Peoples R China

[325] Affiliated Hosp NJMU, Nanjing Drum Tower Hosp, Nanjing, Jiangsu, Peoples R China

[326] Wuhan Asian Heart Hosp, Wuhan, Hubei, Peoples R China

[327] Nanchang Univ, Affiliated Hosp 2, Nanchang, Jiangxi, Peoples R China

[328] Fujian Med Univ, Affiliated Hosp 1, Fuzhou, Fujian, Peoples R China

[329] Third Peoples Hosp Hubei Prov, Wuhan, Hubei, Peoples R China

[330] Tianjin 4th Ctr Hosp, Tianjin, Peoples R China

[331] Southeast Univ, Zhongda Hosp, Nanjing, Jiangsu, Peoples R China

[332] Southern Med Univ, Nanfang Hosp, Guangzhou, Guangdong, Peoples R China

[333] Beijing Chaoyang Hosp, Beijing, Peoples R China

[334] China Japan Friendship Hosp, Beijing, Peoples R China

[335] Baotou Med Coll, Affiliated Hosp 1, Baotou, Peoples R China

[336] Lanzhou Univ, Hosp 1, Lanzhou, Gansu, Peoples R China

[337] Nanchang Univ, Affiliated Hosp 1, Nanchang, Jiangxi, Peoples R China

[338] Nanjing Mil Command, Fuzhou Gen Hosp, Nanjing, Jiangsu, Peoples R China

[339] Chinese Peoples Liberat Army Gen Hosp, Beijing, Peoples R China

[340] China Aerosp Corp, Cent Hosp, Beijing, Peoples R China

[341] Jilin Univ, Hosp 1, Changchun, Jilin, Peoples R China

[342] China Med Univ, Shengjing Hosp, Shenyang, Liaoning, Peoples R China

[343] Cent South Univ, Xiangya Hosp 2, Changsha, Hunan, Peoples R China

[344] Shanghai East Hosp, Shanghai, Peoples R China

[345] Shanghai Sixth Peoples Hosp, Shanghai, Peoples R China

[346] Shanghai First Peoples Hosp, Shanghai, Peoples R China

[347] Zhejiang Hosp, Hangzhou, Zhejiang, Peoples R China

[348] Zhejiang Prov Peoples Hosp, Hangzhou, Zhejiang, Peoples R China

[349] Cent South Univ, Xiangya Hosp 3, Changsha, Hunan, Peoples R China

[350] Capital Med Univ, Beijing Anzhen Hosp, Beijing, Peoples R China

[351] Inner Mongolia Peoples Hosp, Hohhot, Peoples R China

[352] Xi An Jiao Tong Univ, Affiliated Hosp 1, Xian, Shaanxi, Peoples R China

[353] Hunan Prov Peoples Hosp, Changsha, Hunan, Peoples R China

[354] First Peoples Hosp Yueyang, Yueyang, Peoples R China

[355] Capital Med Univ, Beijing Tongren Hosp, Beijing, Peoples R China

[356] Fudan Univ, Zhongshan Hosp, Shanghai, Peoples R China

[357] Zhejiang Univ, Sir Run Run Shaw Hosp, Hangzhou, Zhejiang, Peoples R China

[358] Lanzhou Univ, Hosp 2, Lanzhou, Gansu, Peoples R China

[359] Shanghai Jiao Tong Univ, Shanghai Chest Hosp, Shanghai, Peoples R China

[360] Shaanxi Prov Peoples Hosp, Xian, Shaanxi, Peoples R China

[361] Soochow Univ, Affiliated Hosp 1, Suzhou, Peoples R China

[362] Zhejiang Univ, Affiliated Hosp 2, Hangzhou, Zhejiang, Peoples R China

[363] Ctr Med Ejercicio & Rehabilitac Cardiaca, Medellin, Colombia

[364] Fdn Cardiomet Eje Cafetero CEQUIN, Armenia, Quindio, Colombia

[365] Hosp Santa Clara, Bogota, Colombia

[366] IPS Rodrigo Botero SAS, Medellin, Colombia

[367] Asociac IPS Med Internistas Caldas, Manizales, Colombia

[368] Clin Costa ltda, Barranquilla, Colombia

[369] Fdn Oftalmolog FOSCAL, Bucaramanga, Colombia

[370] Caja Compensac Familiar CAFAM, Bogota, Colombia

[371] Fdn Ctr Invest Biomed Riescard, Espinal Tolima, Colombia

[372] IPS Ctr Med Julian Coronel SA, Cali, Valle, Colombia

[373] IPS Ctr Cient Asistencial Jose Luis Accini SAS, Barranquilla, Colombia

[374] Ctr Cardiovasc Colombiano Clin Santa Maria, Medellin, Colombia

[375] Ctr Med Imbanaco Cali SA, Cali, Valle, Colombia

[376] Ctr Diagnost Cardiol LTDA, Cartagena, Colombia

[377] Ctr Cardiovasc Aristides Sotomayor Santa Lucia SA, Cartagena, Bolivar, Colombia

[378] SIMEDICS IPS SAS, Bogota, Colombia

[379] Fdn Caribe Invest Biomed, Barranquilla, Colombia

[380] FN Brno, Brno, Czech Republic

[381] Krajska Nemocnice Liberec, Liberec, Czech Republic

[382] Fak Nemocnice Hradec Kralove, Hradec Kralove, Czech Republic

[383] Fak Nemocnice Motole, Prague, Czech Republic

[384] InterkardioML SRO, Interni Kardiol Ambulance, Marianske Lazne, Czech Republic

[385] Vseobecna Fak Nemocnice Praze, Prague, Czech Republic

[386] Nemocnice Pardubickeho Kraje AS, Pardubice, Czech Republic

[387] Mestska Nemocnice Ostrava, Ostrava, Czech Republic

[388] Fak Nemocnice Plzen, Plzen, Czech Republic

[389] Ctr Choroby Srdce Cev, Kromeriz, Czech Republic

[390] Krajska Nemocnice Tomase Bati AS, Zlin, Czech Republic

[391] Inst Klin Expt Med, Prague, Czech Republic

[392] Oblastni Nemocnice Kladno AS, Kladno, Czech Republic

[393] Thomayerova Nemocnice, Prague, Czech Republic

[394] Fak Nemocnice Kralovske Vinohrady, Prague, Czech Republic

[395] KARDIO SEVER SRO, Ceska Lipa, Czech Republic

[396] Kardiol Ambulance, Rakovnik, Czech Republic

[397] Nemocnice Na Homolce, Prague, Czech Republic

[398] Fak Nemocnice Olomouc, Olomouc, Czech Republic

[399] Kardiol SRO, Cesky Krumlov, Czech Republic

[400] Cardioctr Kladno SRO, PP Klin Kladno, Kladno, Czech Republic

[401] Dep Cardiol, Aalborg, Denmark

[402] Rigshosp Hjertecentret, Copenhagen, Denmark

[403] Region Hosp Herning, Herning, Denmark

[404] Hvidovre Univ Hosp, Hvidovre, Denmark

[405] Reg Hosp Silkeborg, Silkeborg, Denmark

[406] Gentofte Univ Hosp, Hellerup, Denmark

[407] Naestved Sygehus, Naestved, Denmark

[408] Sygehus Lillebaelt, Vejle Sygehus, Vejle, Denmark

[409] Glostrup Cty Hosp, Glostrup, Denmark

[410] Sjaellands Univ Hosp Koge, Koge, Denmark

[411] Holbaek Sygehus, Holbaek, Denmark

[412] Slagelse Sygehus, Slagelse, Denmark

[413] Reg Hosp Viborg, Viborg, Denmark

[414] Hillerod Hosp, Hillerod, Denmark

[415] Sygehus Sonderjylland, Aabenraa, Denmark

[416] Odense Univ Hosp, Odense C, Denmark

[417] SA Viljandi Haigla, Viljandimaa, Estonia

[418] SA Parnu Haigla, Parnu, Estonia

[419] AS Ida Tallinna Keskhaigla, Tallinn, Estonia

[420] SA Tartu Ulikooli Kliinikum, Tartu, Estonia

[421] Mustamae Tervisekeskus OU, Tallinn, Estonia

[422] Helsinki Univ Hosp, Biomed, Helsinki, Finland

[423] Helsinki Univ Hosp, Div Cardiol, Helsinki, Finland

[424] Turku Univ Hosp, Ctr Heart, Turku, Finland

[425] Tampere Univ Hosp, Ctr Heart, Tampere, Finland

[426] Tampere Univ Hosp, Internal Med, Tampere, Finland

[427] Univ Hosp Oulu, Oulu, Finland

[428] Univ Oulu, Oulu, Finland

[429] Hop Cardiol Haut Leveque, Pessac, France

[430] Hop Louis Pasteur, Nice, France

[431] Nouvel Hop Civil, Strasbourg, France

[432] Hop La Pitie Salpetriere, Paris, France

[433] CHU Albert Michallon, Grenoble, France

[434] CHU Brest, Hop Cavale Blanche, Brest, France

[435] CHU Dijon Bocage Cent, Dijon, France

[436] Hop Bichat Claude Bernard, Paris, France

[437] Hop Arnaud Villeneuve, Montpellier, France

[438] Ctr Hosp Cambrai, Cambrai, France

[439] Ctr Hosp Gen, Pau, France

[440] Hop St Antoine, Paris, France

[441] Hop Nord Marseille, Marseille, France

[442] CH Compiegne Noyon, Compiegne, France

[443] CHU Jean Minjoz, Besancon, France

[444] CHU Dupuytren, Limoges, France

[445] CHU Nantes, Nantes, France

[446] Clin St Hilaire, Rouen, France

[447] Inst Hosp Jacques Cartier, Massy, France

关键词: acute coronary syndromes;    alirocumab;    low-density lipoprotein cholesterol;    major adverse cardiovascular events;    proprotein convertase subtilisin/kexin type 9 inhibition;   

DOI  :  10.1016/j.jacc.2019.10.057

来源: Elsevier

【 摘 要 】

BACKGROUND Lipoprotein(a) concentration is associated with cardiovascular events. Alirocumab, a proprotein convertase subtilisin/kexin type 9 inhibitor, lowers lipoprotein(a) and low-density lipoprotein cholesterol (LDL-C). OBJECTIVES A pre-specified analysis of the placebo-controlled ODYSSEY Outcomes trial in patients with recent acute coronary syndrome (ACS) determined whether alirocumab-induced changes in lipoprotein(a) and LDL-C independently predicted major adverse cardiovascular events (MACE). METHODS One to 12 months after ACS, 18,924 patients on high-intensity statin therapy were randomized to alirocumab or placebo and followed for 2.8 years (median). Lipoprotein(a) was measured at randomization and 4 and 12 months thereafter. The primary MACE outcome was coronary heart disease death, nonfatal myocardial infarction, ischemic stroke, or hospitalization for unstable angina. RESULTS Baseline lipoprotein(a) levels (median: 21.2 mg/dl; interquartile range [IQR]: 6.7 to 59.6 mg/dl) and LDL-C [corrected for cholesterol content in lipoprotein(a)] predicted MACE. Alirocumab reduced lipoprotein(a) by 5.0 mg/dl (IQR: 0 to 13.5 mg/dl), corrected LDL-C by 51.1 mg/dl (IQR: 33.7 to 67.2 mg/dl), and reduced the risk of MACE (hazard ratio [HR]: 0.85; 95% confidence interval [CI]: 0.78 to 0.93). Alirocumab-induced reductions of lipoprotein(a) and corrected LDL-C independently predicted lower risk of MACE, after adjustment for baseline concentrations of both lipoproteins and demographic and clinical characteristics. A 1-mg/dl reduction in lipoprotein(a) with alirocumab was associated with a HR of 0.994 (95% CI: 0.990 to 0.999; p = 0.0081). CONCLUSIONS Baseline lipoprotein(a) and corrected LDL-C levels and their reductions by alirocumab predicted the risk of MACE after recent ACS. Lipoprotein(a) lowering by alirocumab is an independent contributor to MACE reduction, which suggests that lipoprotein(a) should be an independent treatment target after ACS. (ODYSSEY Outcomes: Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab; NCT01663402) (C) 2020 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.

【 授权许可】

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