Impact of Oxidative Stress on the Heart and Vasculature Part 2 of a 3-Part Series

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

卷:70

Review

Muenzel, Thomas¹  Camici, Giovanni G.²  Maack, Christoph³  Bonetti, Nicole R.²  Fuster, Valentin^4,5,6  Kovacic, Jason C.⁴ 

[1] Johannes Gutenberg Univ Mainz, Univ Med Ctr Mainz, Cardiol 1, Ctr Cardiol Mainz, Mainz, Germany

[2] Univ Zurich, Ctr Mol Cardiol, Wagistrasse 12, CH-8952 Schlieren, Switzerland

[3] Univ Klinikum Saarlandes, Klin Innere Med 3, Homburg, Germany

[4] Icahn Sch Med Mt Sinai, Zena & Michael A Wiener Cardiovasc Inst, New York, NY 10029 USA

[5] Icahn Sch Med Mt Sinai, Marie Josee & Henry R Kravis Cardiovasc Hlth Ctr, New York, NY 10029 USA

[6] Ctr Nacl Invest Cardiovasc, Madrid, Spain

关键词: cardiac;    reactive oxygen species;    vascular;   

DOI  :  10.1016/j.jacc.2017.05.035

来源: Elsevier

【 摘 要 】

Vascular disease and heart failure impart an enormous burden in terms of global morbidity and mortality. Although there are many different causes of cardiac and vascular disease, most causes share an important pathological mechanism: oxidative stress. In the failing heart, oxidative stress occurs in the myocardium and correlates with left ventricular dysfunction. Reactive oxygen species (ROS) negatively affect myocardial calcium handling, cause arrhythmia, and contribute to cardiac remodeling by inducing hypertrophic signaling, apoptosis, and necrosis. Similarly, oxidative balance in the vasculature is tightly regulated by a wealth of pro- and antioxidant systems that orchestrate region-specific ROS production and removal. Reactive oxygen species also regulate multiple vascular cell functions, including endothelial and smooth muscle cell growth, proliferation, and migration; angiogenesis; apoptosis; vascular tone; host defenses; and genomic stability. However, excessive levels of ROS promote vascular disease through direct and irreversible oxidative damage to macromolecules, as well as disruption of redox-dependent vascular wall signaling processes. (C) 2017 by the American College of Cardiology Foundation.

【 授权许可】

Free