Healthy Lifestyle in the Primordial Prevention of Cardiovascular Disease Among Young Women

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

卷:65

Article

Chomistek, Andrea K.¹  Chiuve, Stephanie E.²  Eliassen, A. Heather^3,4,5  Mukamal, Kenneth J.⁶  Willett, Walter C.^2,3,4,5  Rimm, Eric B.^2,3,4,5 

[1] Indiana Univ, Sch Publ Hlth, Dept Epidemiol & Biostatist, Bloomington, IN 47405 USA

[2] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA

[3] Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA 02115 USA

[4] Harvard Univ, Sch Med, Boston, MA USA

[5] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[6] Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA 02215 USA

关键词: coronary disease;    diabetes;    epidemiology;    hypercholesterolemia;    hypertension;    risk factors;   

DOI  :  10.1016/j.jacc.2014.10.024

来源: Elsevier

【 摘 要 】

BACKGROUND Overall mortality rates from coronary heart disease (CHD) in the United States have declined in recent decades, but the rate has plateaued among younger women. The potential for further reductions in mortality rates among young women through changes in lifestyle is unknown. OBJECTIVES The aim of this study was to estimate the proportion of CHD cases and clinical cardiovascular disease (CVD) risk factors among young women that might be attributable to poor adherence to a healthy lifestyle. METHODS A prospective analysis was conducted among 88,940 women ages 27 to 44 years at baseline in the Nurses' Health Study II who were followed from 1991 to 2011. Lifestyle factors were updated repeatedly by questionnaire. A healthy lifestyle was defined as not smoking, a normal body mass index, physical activity >= 2.5 h/week, television viewing <= 7 h/week, diet in the top 40% of the Alternative Healthy Eating Index-2010, and 0.1 to 14.9 g/day of alcohol. To estimate the proportion of CHD and clinical CVD risk factors (diabetes, hypertension, and hypercholesterolemia) that could be attributed to poor adherence to a healthy lifestyle, we calculated the population-attributable risk percent. RESULTS During 20 years of follow-up, we documented 456 incident CHD cases. In multivariable-adjusted models, nonsmoking, a healthy body mass index, exercise, and a healthy diet were independently and significantly associated with lower CHD risk. Compared with women with no healthy lifestyle factors, the hazard ratio for CHD for women with 6 lifestyle factors was 0.08 (95% confidence interval: 0.03 to 0.22). Approximately 73% (95% confidence interval: 39% to 89%) of CHD cases were attributable to poor adherence to a healthy lifestyle. Similarly, 46% (95% confidence interval: 43% to 49%) of clinical CVD risk factor cases were attributable to a poor lifestyle. CONCLUSIONS Primordial prevention through maintenance of a healthy lifestyle among young women may substantially lower the burden of CVD. (C) 2015 by the American College of Cardiology Foundation.

【 授权许可】

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