Improved Outcomes of Heart Transplantation in Adults With Congenital Heart Disease Receiving Regionalized Care

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

卷:74

Article

Nguyen, Vidang P.¹  Dolgner, Stephen J.^2,3  Dardas, Todd F.¹  Verrier, Edward D.⁴  McMullan, D. Michael⁵  Krieger, Eric V.^1,3 

[1] Univ Washington, Dept Med, Div Cardiol, Seattle, WA USA

[2] Univ Washington, Dept Pediat, Seattle, WA 98195 USA

[3] Seattle Childrens Hosp, Div Cardiol, Seattle, WA USA

[4] Univ Washington, Div Cardiothorac Surg, Seattle, WA 98195 USA

[5] Seattle Childrens Hosp, Div Cardiac Surg, Seattle, WA USA

关键词: Adult Congenital Heart Association;    adult congenital heart disease;    center;    heart transplantation;    United Network of Organ Sharing;   

DOI  :  10.1016/j.jacc.2019.09.062

来源: Elsevier

【 摘 要 】

BACKGROUND The number of adult congenital heart disease (CHD) patients undergoing heart transplantation is increasing rapidly. CHD patients have higher surgical risk at transplantation. High-volume adult CHD transplant centers may have better transplant outcomes. OBJECTIVES This study aimed to evaluate the effect of center CHD transplant volume and expertise on transplant outcomes in CHD patients. METHODS The authors studied heart transplantations in CHD patients age >= 18 years using the United Network of Organ Sharing (UNOS) database for the primary outcomes of waitlist mortality and post-transplant outcomes at 30 days and 1 year. Transplant centers were assessed by status as the highest CHD transplant volume center in a UNOS region versus all others, presence of Adult Congenital Heart Association accreditation, and adult versus pediatric hospital designation. RESULTS Between January of 2000 and June of 2018, 1,746 adult CHD patients were listed for transplant; 1,006 (57.6%) of these underwent heart transplantation. After adjusting for age, sex, listing status, and inotrope requirement, waitlist mortality risk was lower at Adult Congenital Heart Association accredited centers (hazard ratio: 0.730; p = 0.020). Post-transplant 30-day mortality was lower at the highest volume CHD transplant center in each UNOS region (hazard ratio: 0.706; p = 0.014). CONCLUSIONS Designated expertise in CHD care is associated with improved waitlist outcomes for CHD patients listed for transplantation. Post-transplant survival was improved at the highest volume regional center. These findings suggest a possible advantage of regionalization of CHD transplantation. (C) 2019 by the American College of Cardiology Foundation.

【 授权许可】

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