Vascular Responses to Long- and Short-Term Exposure to Fine Particulate Matter MESA Air (Multi-Ethnic Study of Atherosclerosisi and Air Pollution)

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

卷:60

Article

Krishnan, Ranjini M.^1,2  Adar, Sara D.^2,3  Szpiro, Adam A.⁴  Jorgensen, Neal W.⁴  Van Hee, Victor C.^1,2  Barr, R. Graham⁵  O'Neill, Marie S.^3,6  Herrington, David M.^7,9  Polak, Joseph F.⁸  Kaufman, Joel D.^1,2,9 

[1] Univ Washington, Dept Med, Seattle, WA 98105 USA

[2] Univ Washington, Dept Environm & Occupat Hlth Sci, Seattle, WA 98195 USA

[3] Univ Michigan, Dept Epidemiol, Ann Arbor, MI 48109 USA

[4] Univ Washington, Dept Biostat, Seattle, WA 98195 USA

[5] Columbia Univ, Dept Med & Epidemiol, New York, NY USA

[6] Univ Michigan, Dept Environm Hlth Sci, Ann Arbor, MI 48109 USA

[7] Wake Forest Hlth Univ, Dept Internal Med Cardiol, Winston Salem, NC USA

[8] Tufts Med Ctr, Dept Radiol, Boston, MA USA

[9] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA

关键词: air pollution;    atherosclerosis;    cardiovascular mortality;    endothelial function;    flow-mediated dilation;    traffic;   

DOI  :  10.1016/j.jacc.2012.08.973

来源: Elsevier

【 摘 要 】

Objectives This study evaluated the association of long- and short-term air pollutant exposures with flow-mediated dilation (FMD) and baseline arterial diameter (BAD) of the brachial artery using ultrasound in a large multicity cohort. Background Exposures to ambient air pollution, especially long-term exposure to particulate matter <2.5 mu m in aerodynamic diameter (PM2.5), are linked with cardiovascular mortality. Short-term exposure to PM2.5 has been associated with decreased FMD and vasoconstriction, suggesting that adverse effects of PM2.5 may involve endothelial dysfunction. However, long-term effects of PM2.5 on endothelial dysfunction have not been investigated. Methods FMD and BAD were measured by brachial artery ultrasound at the initial examination of the Multi-Ethnic Study of Atherosclerosis. Long-term PM2.5 concentrations were estimated for the year 2000 at each participant's residence (n = 3,040) using a spatio-temporal model informed by cohort-specific monitoring. Short-term PM2.5 concentrations were based on daily central-site monitoring in each of the 6 cities. Results An interquartile increase in long-term PM2.5 concentration (3 mu g/m(3)) was associated with a 0.3% decrease in FMD (95% confidence interval [CI] of difference: -0.6 to -0.03; p = 0.03), adjusting for demographic characteristics, traditional risk factors, sonographers, and 1/BAD. Women, nonsmokers, younger participants, and those with hypertension seemed to show a greater association of PM2.5 with FMD. FMD was not significantly associated with short-term variation in PM2.5 (-0.1% per 12 mu g/m(3) daily increase [95% CI: -0.2 to 0.04] on the day before examination). Conclusions Long-term PM2.5 exposure was significantly associated with decreased endothelial function according to brachial ultrasound results. These findings may elucidate an important pathway linking air pollution and cardiovascular mortality. (Multi-Ethnic Study of Atherosclerosis [MESA]; NCT00005487) (J Am Coll Cardiol 2012;60:2158-66) (C) 2012 by the American College of Cardiology Foundation

【 授权许可】

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