Preparing the United States for High-Sensitivity Cardiac Troponin Assays

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

卷:61

Review

Korley, Frederick K.¹  Jaffe, Allan S.^2,3,4 

[1] Johns Hopkins Univ, Sch Med, Dept Emergency Med, Baltimore, MD USA

[2] Mayo Clin & Mayo Grad Sch Med, Dept Med, Div Cardiovasc, Rochester, MN 55905 USA

[3] Mayo Clin & Mayo Grad Sch Med, Dept Med, Div Core Clin Lab Serv, Rochester, MN 55905 USA

[4] Mayo Clin & Mayo Grad Sch Med, Dept Lab Med & Pathol, Rochester, MN 55905 USA

关键词: high-sensitivity troponin;    ischemia;    myocardial infarction;   

DOI  :  10.1016/j.jacc.2012.09.069

来源: Elsevier

【 摘 要 】

It is only a matter of time before the use of high-sensitivity cardiac troponin assays (hs-cTn) becomes common throughout the United States. In preparation for this inevitability, this article raises a number of important issues regarding these assays that deserve consideration. These include: the need for the adoption of a universal nomenclature; the importance of defining uniform criteria for reference populations; the challenge of discriminating between acute and nonacute causes of hs-cTn elevations, and between type 1 and type 2 acute myocardial infarction (AMI); factors influencing the analytical precision of hs-cTn; ascertaining the optimal duration of the rule-out period for AMI; the need for further evaluation to determine the causes of a positive hs-cTn in non-AMI patients; and the use of hs-cTn to risk-stratify patients with disease conditions other than AMI. This review elaborates on these critical issues as a means of educating clinicians and researchers about them. (J Am Coll Cardiol 2013;61:1753-8) (C) 2013 by the American College of Cardiology Foundation

【 授权许可】

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