Coronary Computed Tomography Angiography From Clinical Uses to Emerging Technologies JACC State-of-the-Art Review

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

卷:76

Review

Abdelrahman, Khaled M.¹  Chen, Marcus Y.¹  Dey, Amit K.¹  Virmani, Renu²  Finn, Aloke V.²  Khamis, Ramzi Y.³  Choi, Andrew D.^4,5  Min, James K.^6,7  Williams, Michelle C.^8,9  Buckler, Andrew J.¹⁰  Taylor, Charles A.¹¹  Rogers, Campbell¹¹  Samady, Habib¹²  Antoniades, Charalambos¹³  Shaw, Leslee J.^6,7  Budoff, Matthew J.¹⁴  Hoffmann, Udo¹⁵  Blankstein, Ron^16,17  Narula, Jagat¹⁸  Mehta, Nehal N.¹ 

[1] NHLBI, NIH, Bldg 10, Bethesda, MD 20892 USA

[2] CVPath Inst, Dept Pathol, Gaithersburg, MD USA

[3] Imperial Coll London, Natl Heart & Lung Inst, Vasc Sci Sect, London, England

[4] George Washington Univ, Sch Med, Div Cardiol, Washington, DC USA

[5] George Washington Univ, Sch Med, Dept Radiol, Washington, DC USA

[6] New York Presbyterian Hosp, Dept Radiol, New York, NY USA

[7] Weill Cornell Med, New York, NY USA

[8] Univ Edinburgh, British Heart Fdn Ctr Cardiovasc Sci, Edinburgh, Midlothian, Scotland

[9] Univ Edinburgh, Queens Med Res Inst, Edinburgh Imaging, Edinburgh, Midlothian, Scotland

[10] Elucid Bioimaging, Boston, MA USA

[11] HeartFlow Inc, Redwood City, CA USA

[12] Emory Univ, Sch Med, Div Cardiol, Atlanta, GA 30322 USA

[13] Univ Oxford, Radcliffe Dept Med, Div Cardiovasc Med, Oxford, England

[14] Harbor UCLA Med Ctr, Lundquist Inst, Torrance, CA 90509 USA

[15] Harvard Med Sch, Massachusetts Gen Hosp, Dept Radiol, Boston, MA 02115 USA

[16] Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Cardiovasc Div, Boston, MA 02115 USA

[17] Harvard Med Sch, Brigham & Womens Hosp, Dept Radiol, Boston, MA 02115 USA

[18] Icahn Sch Med Mt Sinai, Mt Sinai Heart, Marie Josee & Henry R Kravis Ctr Cardiovasc Hlth, Zena & Michael Wiener Cardiovasc Inst, New York, NY 10029 USA

关键词: atherosclerosis;    coronary artery disease;    coronary computed tomography angiography;   

DOI  :  10.1016/j.jacc.2020.06.076

来源: Elsevier

【 摘 要 】

Evaluation of coronary artery disease (CAD) using coronary computed tomography angiography (CCTA) has seen a paradigm shift in the last decade. Evidence increasingly supports the clinical utility of CCTA across various stages of CAD, from the detection of early subctinicat disease to the assessment of acute chest pain. Additionally, CCTA can be used to noninvasively quantify plaque burden and identify high-risk plaque, aiding in diagnosis, prognosis, and treatment. This is especially important in the evaluation of CAD in immune-driven conditions with increased cardiovascular disease prevalence. Emerging applications of CCTA based on hemodynamic indices and plaque characterization may provide personalized risk assessment, affect disease detection, and further guide therapy. This review provides an update on the evidence, clinical applications, and emerging technologies surrounding CCTA as highlighted at the 2019 National Heart, Lung and Blood Institute CCTA Summit. Published by Elsevier on behalf of the American College of Cardiology Foundation.

【 授权许可】

Free