Risk Factor Variability and Cardiovascular Outcome JACC Review Topic of the Week

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

卷:73

Review

Messerli, Franz H.^1,2,3  Hofstetter, Louis¹  Rimoldi, Stefano F.¹  Rexhaj, Emrush¹  Bangalore, Sripal⁴ 

[1] Univ Hosp, Dept Cardiol & Clin Res, Bern, Switzerland

[2] Jagiellonian Univ, Krakow, Poland

[3] Icahn Sch Med, Mt Sinai Hlth Med Ctr, Div Cardiol, New York, NY USA

[4] NYU, Sch Med, Leon H Charney Div Cardiol, New York, NY USA

关键词: blood pressure;    body weight;    cholesterol;    glycemia;    heart rate;    mortality;   

DOI  :  10.1016/j.jacc.2019.02.063

来源: Elsevier

【 摘 要 】

Until recently, intraindividual visit-to-visit variability of cardiovascular risk factors has been dismissed as random fluctuation. This simplistic concept was challenged by demonstrating that visit-to-visit blood pressure variability, independent of average blood pressure, was a powerful risk factor for stroke. Subsequently, variability of other cardiovascular risk factors such as cholesterol, glycemia, and body weight was documented to increase risk independent of their absolute values. Variability of these risk factors has been demonstrated to be a powerful predictor for all-cause and cardiovascular mortality, stroke, coronary artery disease, heart failure, end-stage renal disease, and dementia. With the notable exception of heart rate, cardiovascular risk factors must now be defined by 2 components: the magnitude and duration of sustained risk factor elevation and, equally important, the variability of the same risk factor over time. (C) 2019 by the American College of Cardiology Foundation.

【 授权许可】

Free