Novel Approaches for Preventing or Limiting Events (Naples) II Trial Impact of a Single High Loading Dose of Atorvastatin on Periprocedural Myocardial Infarction

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

卷:54

Article

Briguori, Carlo^1,2,3  Visconti, Gabriella^1,2  Focaccio, Amelia^1,2  Golia, Bruno^1,2  Chieffo, Alaide³  Castelli, Alfredo³  Mussardo, Marco³  Montorfano, Matteo³  Ricciardelli, Bruno^1,2  Colombo, Antonio³ 

[1] Clin Mediterranea, Lab Intervent Cardiol, I-80121 Naples, Italy

[2] Clin Mediterranea, Dept Cardiol, I-80121 Naples, Italy

[3] Vita e Salute Univ, Lab Intervent Cardiol, Sch Med, San Raffaele Sci Inst, Milan, Italy

关键词: statin;    angioplasty;    stent;    complication;    myocardial infarction;   

DOI  :  10.1016/j.jacc.2009.07.005

来源: Elsevier

【 摘 要 】

Objectives Atorvastatin administered at least 7 days before the percutaneous coronary intervention (PCI) reduces the rate of periprocedural myocardial infarction (MI). It is unknown whether a single, high (80 mg) loading dose of atorvastatin may reduce the rate of periprocedural MI. Background Periprocedural MI is a prognostically important complication of PCI. Methods The day before the elective PCI, 668 statin-naive patients were randomly assigned to atorvastatin 80 mg (atorvastatin group; n = 338) or no statin treatment (control group; n = 330). Creatine kinase-myocardial isoenzyme (CK-MB) (upper limit of normal [ULN] 3.5 ng/ml) and cardiac troponin I (ULN 0.10 ng/ml) were assessed before and 6 and 12 h after the intervention. Periprocedural MI was defined as a CK-MB elevation >3x ULN alone or associated with chest pain or ST-segment or T-wave abnormalities. Results The incidence of a periprocedural MI was 9.5% in the atorvastatin group and 15.8% in the control group (odds ratio: 0.56; 95% confidence interval: 0.35 to 0.89; p = 0.014). Median CK-MB peak after PCI was 2.10 ng/ml (interquartile range 1.00 to 12.50 ng/ml) in the atorvastatin group and 3.20 ng/ml (interquartile range 1.37 to 16.07 ng/ml) in the control group (p = 0.014). The incidence of cardiac troponin I elevation >3x ULN was 26.6% in the atorvastatin group and 39.1% in the control group (odds ratio: 0.56; 95% confidence interval: 0.40 to 0.78; p < 0.001). Conclusions A single, high (80 mg) loading (within 24 h) dose of atorvastatin reduces the incidence of periprocedural MI in elective PCI. (J Am Coll Cardiol 2009;54:2157-63) (C) 2009 by the American College of Cardiology Foundation

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