Does a Ripple of Ca2+ Leak Develop Into a Rogue Wave That Can Trigger Pathological Hypertrophy?

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

卷:63

Editorial Material

Yano, Masafumi¹  Okuda, Shinichi¹ 

[1] Yamaguchi Univ, Grad Sch Med, Dept Med & Clin Sci, Div Cardiol, Ube, Yamaguchi 7558505, Japan

关键词: calcium;    heart failure;    hypertension;    remodeling;    ryanodine receptor;   

DOI  :  10.1016/j.jacc.2013.10.064

来源: Elsevier

【 摘 要 】

Calcium (Ca2+) is known to be a key messenger in cardiac excitation-contraction coupling. Alterations in excitation-contraction coupling reportedly play a crucial role in the pathogenesis of heart failure and lethal arrhythmias, such as catecholaminergic polymorphic ventricular tachycardia (CPVT) (1,2). The common pathophysiologic phenomenon occurring in the 2 above-mentioned heart diseases is termed as a diastolic Ca2+ leak, which involves an aberrant release of Ca2+ during diastole via the cardiac ryanodine receptor (RyR2) ( 3).

【 授权许可】

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