Anatomic Versus Physiologic Assessment of Coronary Artery Disease

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

卷:62

Article

Gould, K. Lance¹  Johnson, Nils P.¹  Bateman, Timothy M.^2,3  Beanlands, Rob S.⁴  Bengel, Frank M.⁵  Bober, Robert⁶  Camici, Paolo G.^7,8  Cerqueira, Manuel D.⁹  Chow, Benjamin J. W.⁴  Di Carli, Marcelo F.^10,11  Dorbala, Sharmila^10,11  Gewirtz, Henry¹²  Gropler, Robert J.¹³  Kaufmann, Philipp A.¹⁴  Knaapen, Paul¹⁵  Knuuti, Juhani^16,17  Merhige, Michael E.¹⁸  Rentrop, K. Peter¹⁹  Ruddy, Terrence D.⁴  Schelbert, Heinrich R.²⁰  Schindler, Thomas H.²¹  Schwaiger, Markus²²  Sdringola, Stefano¹  Vitarello, John²³  Williams, Kim A.²⁴  Gordon, Donald²⁵  Dilsizian, Vasken²⁶  Narula, Jagat²⁷ 

[1] Univ Texas Houston, Med Sch Houston, Weatherhead PET Ctr Preventing & Reversing Athero, Div Cardiol,Dept Med, Houston, TX 77030 USA

[2] Cardiovasc Consultants PA, Mid Amer Heart Inst, Kansas City, MO USA

[3] Univ Missouri, Kansas City, MO 64110 USA

[4] Univ Ottawa, Inst Heart, Dept Med Cardiol, Ottawa, ON, Canada

[5] Hannover Med Sch, Klin Nukl Med, D-30623 Hannover, Germany

[6] Ochsner Med Ctr, New Orleans, LA USA

[7] Univ Vita Salute San Raffaele, Milan, Italy

[8] Ist Sci San Raffaele, I-20132 Milan, Italy

[9] Cleveland Clin Fdn, Dept Mol & Funct Imaging, Cleveland, OH 44195 USA

[10] Brigham & Womens Hosp, Div Cardiovasc Med, Cardiovasc Imaging Program, Boston, MA 02115 USA

[11] Brigham & Womens Hosp, Div Nucl Med, Boston, MA 02115 USA

[12] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Cardiol Div,Dept Med, Boston, MA USA

[13] Washington Univ, Sch Med, Mallinckrodt Inst Radiol, Div Radiol Sci, St Louis, MO USA

[14] Univ Zurich Hosp, Cardiac Imaging & Zurich Ctr Integrat Human Physi, CH-8091 Zurich, Switzerland

[15] Vrije Univ Amsterdam Med Ctr, Dept Cardiol, Amsterdam, Netherlands

[16] Univ Turku, Turku PET Ctr, Turku, Finland

[17] Turku Univ Hosp, FIN-20520 Turku, Finland

[18] Heart Ctr Niagara, Niagara Falls, NY USA

[19] Gramercy Cardiac Diagnost, New York, NY USA

[20] Univ Calif Los Angeles, David Geffen Sch Med, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA

[21] Univ Hosp Geneva, Div Cardiol, Dept Med Specialties, Geneva, Switzerland

[22] Tech Univ Munich, Nukl Med Klin & Poliklin, D-80290 Munich, Germany

[23] Cardiovasc Specialists Frederick, Frederick, MD USA

[24] Wayne State Univ, Sch Med, Div Cardiovasc Med, Detroit, MI USA

[25] Cardiovasc Associates Southeast, Birmingham, AL USA

[26] Univ Maryland, Sch Med, Dept Diagnost Radiol & Nucl Med, Baltimore, MD 21201 USA

[27] Mt Sinai Sch Med, Zena & Michael A Weiner Cardiovasc Inst, New York, NY USA

关键词: coronary flow;    coronary physiology;    ischemia;    PET perfusion imaging;    revascularization;   

DOI  :  10.1016/j.jacc.2013.07.076

来源: Elsevier

【 摘 要 】

Angiographic severity of coronary artery stenosis has historically been the primary guide to revascularization or medical management of coronary artery disease. However, physiologic severity defined by coronary pressure and/ or flow has resurged into clinical prominence as a potential, fundamental change from anatomically to physiologically guided management. This review addresses clinical coronary physiology-pressure and flowd-as clinical tools for treating patients. We clarify the basic concepts that hold true for whatever technology measures coronary physiology directly and reliably, here focusing on positron emission tomography and its interplay with intracoronary measurements.

【 授权许可】

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