Relationship of Lipoproteins to Cardiovascular Events The AIM-HIGH Trial (Atherothrombosis Intervention in Metabolic Syndrome With Low HDL/High Triglycerides and Impact on Global Health Outcomes)

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

卷:62

Article

Guyton, John R.¹  Slee, April E.²  Anderson, Todd³  Fleg, Jerome L.⁴  Goldberg, Ronald B.⁵  Kashyap, Moti L.^6,7  Marcovina, Santica M.⁸  Nash, Stephen D.⁹  O'Brien, Kevin D.⁸  Weintraub, William S.¹⁰  Xu, Ping²  Zhao, Xue-Qiao⁸  Boden, William E.¹¹ 

[1] Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA

[2] Axio Res, Seattle, WA USA

[3] Univ Calgary, Libin Cardiovasc Inst, Calgary, AB, Canada

[4] NHLBI, Bethesda, MD 20892 USA

[5] Univ Miami, Leonard M Miller Sch Med, Dept Med, Hollywood, FL USA

[6] Vet Affairs Med Ctr, Long Beach, CA USA

[7] Univ Calif Irvine, Dept Med, Irvine, CA 92717 USA

[8] Univ Washington, Dept Med, Seattle, WA USA

[9] SUNY Hlth Sci Ctr, Dept Med, Syracuse, NY 13210 USA

[10] Ctr Heart & Vasc Hlth, Newark, DE USA

[11] Samuel S Stratton VA Med Ctr, Dept Med, Albany, NY USA

关键词: cardiovascular events;    clinical trial;    GPR109A;    lipoproteins;    niacin;   

DOI  :  10.1016/j.jacc.2013.07.023

来源: Elsevier

【 摘 要 】

Objectives This study sought to examine the relationship between niacin treatment, lipoproteins, and cardiovascular (CV) outcomes in this secondary analysis of the AIM-HIGH (Atherothrombosis Intervention in Metabolic Syndrome With Low HDL/High Triglycerides and Impact on Global Health Outcomes) trial. Background During a 3-year follow-up in 3,414 patients with established CV disease and low high-density lipoprotein cholesterol (HDL-C) levels, combined niacin + low-density lipoprotein cholesterol (LDL-C)-lowering therapy did not reduce CV events compared with LDL-C-lowering therapy alone. Methods Subjects taking simvastatin and/or ezetimibe were randomized to receive extended-release (ER) niacin 1,500 to 2,000 mg or minimal immediate-release niacin (<= 150 mg) as placebo at bedtime. LDL-C levels in both groups were maintained from 40 to 80 mg/dl. Hazard ratios were estimated by using Cox proportional hazards models for relationships between lipoproteins and the composite endpoint of CV death, myocardial infarction, acute coronary syndrome, ischemic stroke, or symptom-driven revascularization. Results CV outcomes were not associated with ER niacin in any baseline lipoprotein tertile. In a subset of patients in both the highest triglyceride (>= 198 mg/dl) and lowest HDL-C (<33 mg/dl) tertiles, ER niacin showed a trend toward benefit (hazard ratio: 0.74, p = 0.073). In-trial LDL-C levels, non-HDL-C levels, and the total cholesterol/HDL-C ratio were positively associated with CV events in the control group, but these relationships were absent in the ER niacin group. Conclusions Baseline lipoprotein tertiles did not predict differential benefit or harm with ER niacin added to LDL-C-lowering therapy, but a small dyslipidemic subgroup may benefit. ER niacin attenuated expected relationships of lipoprotein risk factors with CV events, raising the possibility that nonlipoprotein actions of niacin could affect risk. (Niacin Plus Statin to Prevent Vascular Events [AIM-HIGH]; NCT00120289) (C) 2013 by the American College of Cardiology Foundation

【 授权许可】

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