Intracoronary Cardiosphere-Derived Cells After Myocardial Infarction

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

卷:63

Article

Malliaras, Konstantinos¹  Makkar, Raj R.¹  Smith, Rachel R.¹  Cheng, Ke¹  Wu, Edwin²  Bonow, Robert O.²  Marban, Linda¹  Mendizabal, Adam³  Cingolani, Eugenio¹  Johnston, Peter V.⁴  Gerstenblith, Gary⁴  Schuleri, Karl H.⁴  Lardo, Albert C.^4,5  Marban, Eduardo¹ 

[1] Cedars Sinai Heart Inst, Los Angeles, CA 90048 USA

[2] Northwestern Univ, NW Mem Hosp, Feinberg Sch Med, Div Cardiol,Dept Med,Bluhm Cardiovasc Inst, Chicago, IL 60611 USA

[3] EMMES Corp, Rockville, MD USA

[4] Johns Hopkins Univ, Dept Med, Div Cardiol, Baltimore, MD USA

[5] Johns Hopkins Univ, Dept Biomed Engn, Baltimore, MD USA

关键词: cardiosphere-derived cells;    myocardial infarction;    myocardial regeneration;   

DOI  :  10.1016/j.jacc.2013.08.724

来源: Elsevier

【 摘 要 】

s This study sought to report full 1-year results, detailed magnetic resonance imaging analysis, and determinants of efficacy in the prospective, randomized, controlled CADUCEUS (CArdiosphere-Derived aUtologous stem CElls to reverse ventricUlar dySfunction) trial. Cardiosphere-derived cells (CDCs) exerted regenerative effects at 6 months in the CADUCEUS trial. Complete results at the final 1-year endpoint are unknown. Autologous CDCs (12.5 to 25 +/- 106) grown from endomyocardial biopsy specimens were infused via the intracoronary route in 17 patients with left ventricular dysfunction 1.5 to 3 months after myocardial infarction (MI) (plus 1 infused off-protocol 14 months post-MI). Eight patients were followed as routine-care control patients. In 13.4 months of follow-up, safety endpoints were equivalent between groups. At 1 year, magnetic resonance imaging revealed that CDC-treated patients had smaller scar size compared with control patients. Scar mass decreased and viable mass increased in CDC-treated patients but not in control patients. The single patient infused 14 months post-MI responded similarly. CDC therapy led to improved regional function of infarcted segments compared with control patients. Scar shrinkage correlated with an increase in viability and with improvement in regional function. Scar reduction correlated with baseline scar size but not with a history of temporally remote MI or time from MI to infusion. The changes in left ventricular ejection fraction in CDC-treated subjects were consistent with the natural relationship between scar size and ejection fraction post-MI. Intracoronary administration of autologous CDCs did not raise significant safety concerns. Preliminary indications of bioactivity include decreased scar size, increased viable myocardium, and improved regional function of infarcted myocardium at 1 year post-treatment. These results, which are consistent with therapeutic regeneration, merit further investigation in future trials. (CArdiosphere-Derived aUtologous stem CElls to reverse ventricUlar dySfunction [ CADUCEUS]; NCT00893360) (C) 2014 by the American College of Cardiology Foundation

【 授权许可】

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