Alirocumab in Patients With Polyvascular Disease and Recent Acute Coronary Syndrome ODYSSEY OUTCOMES Trial

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

卷:74

Article

Jukema, J. Wouter¹  Szarek, Michael²  Zijlstra, Laurien E.¹  Bhatt, Deepak L.^4,5  Bittner, Vera A.⁶  Diaz, Rafael⁷  Edelberg, Jay M.⁸  Hanotin, Corinne¹²  Harrington, Robert A.¹³  Moryusef, Angle⁸  White, Harvey D.¹⁹  Zeiher, Andreas M.²⁰  Schwartz, Gregory G.²¹  Steg, P. Gabriel^23,24  Tricoci, Pierluigi⁸⁹  Mahaffey, Kenneth W.⁹⁰  Lecorps, Guillaume¹²  Pordy, Robert¹⁵  Drexel, Heinz^26,172  Sinnaeve, Peter²⁷  Dilic, Mirza²⁸  Gotcheva, Nina N.²⁹  Prieto, Juan-Carlos³⁰  Yong, Huo³¹  Lopez-Jaramillo, Patricio³²  Pecin, Ivan³³  Reiner, Zeljko³⁴  Poulsen, Steen Hvitfeldt³⁶  Viigimaa, Margus³⁷  Nieminen, Markku S.³⁸  Danchin, Nicolas³⁹  Chumburidze, Vakhtang⁴⁰  Tse, Hung-Fat⁴⁴  Xavier, Denis⁴⁶  Zahger, Doron⁴⁷  Valgimigli, Marco⁴⁸  Kim, Hyo Soo⁵⁰  Erglis, Andrejs⁵³  Laucevicius, Aleksandras⁵⁴  Lopez, Ramos⁵⁷  Ramos Lopez, Gabriel Arturo⁵⁷  Alings, Marco⁵⁸  Chua, Terrance⁶⁶  Murin, Jan⁶⁷  Fras, Zlatko⁶⁸  Dalby, Anthony J.⁶⁹  Tunon, Jose⁷⁰  de Silva, H. Asita^3,71  Chiang, Chern-En⁷⁴  Sritara, Piyamitr⁷⁵  Guneri, Sema⁷⁶  Parkhomenko, Alexander⁷⁷  Ray, Kausik K.⁷⁸  Moriarty, Patrick M.⁷⁹  Roe, Matthew T.^18,80  Chaitman, Bernard⁸²  Kelsey, Sheryl F.⁸³  Olsson, Anders G.⁸⁴  Rouleau, Jean-Lucien⁸⁵  Simoons, Maarten L.⁸⁶  Alexander, Karen⁸⁷  Meloni, Chiara¹⁷  Rosenson, Robert⁸⁸  Sijbrands, Eric J. G.⁸⁶  Alexander, John H.⁸⁹  Armaganijan, Luciana⁹¹  Bagai, Akshay¹¹  Bahit, Maria Cecilia⁹¹  Brennan, J. Matthew⁸⁹  Clifton, Shaun⁸⁹  DeVore, Adam D.⁸⁹  Deloatch, Shalonda⁸⁹  Dickey, Sheila⁸⁹  Dombrowski, Keith⁸⁹  Ducrocq, Gregory^89,22  Eapen, Zubin⁸⁹  Endsley, Patricia⁸⁹  Eppinger, Arleen⁸⁹  Harrison, Robert W.⁸⁹  Hess, Connie Ng⁸¹  Hlatky, Mark A.⁹⁰  Jordan, Joseph Dedrick⁹²  Knowles, Joshua W.⁹⁰  Kolls, Bradley J.⁸⁹  Kong, David F.⁸⁹  Leonardi, Sergio⁹³  Lillis, Linda⁸⁹  Maron, David J.⁹⁰  Marcus, Jill⁸⁹  Mathews, Robin⁸⁹  Mehta, Rajendra H.^89,286  Mentz, Robert J.⁸⁹  Moreira, Humberto Graner⁹¹  Patel, Chetan B.⁸⁹  Pereira, Sabrina Bernardez⁹¹  Perkins, Lynn⁸⁹  Povsic, Thomas J.⁸⁹  Puymirat, Etienne⁹⁴  Jones, William Schuyler⁸⁹  Shah, Bimal R.⁸⁹  Sherwood, Matthew W.⁸⁹  Stringfellow, Kenya⁸⁹  Sujjavanich, Darin⁸⁹  Toma, Mustafa⁹⁵  Van Diepen, Sean F. P.⁹  Wilson, Matthew D.⁸⁹  Yan, Andrew Tze-Kay¹¹  Lopes, Renato D.^89,238  Trotter, Charlene⁸⁹  Schiavi, Lilia B.⁹⁶  Garrido, Marcelo⁹⁷  Alvarisqueta, Andres F.⁹⁸  Sassone, Sonia A.⁹⁹  Bordonava, Anselmo P.¹⁰⁰  Alves De Lima, Alberto E.¹⁰¹  Schmidberg, Jorge M.¹⁰²  Duronto, Ernesto A.¹⁰³  Caruso, Orlando C.¹⁰⁴  Novaretto, Leonardo P.¹⁰⁵  Angel Hominal, Miguel¹⁰⁶  Montana, Oscar R.¹⁰⁷  Caccavo, Alberto¹⁰⁸  Gomez Vilamajo, Oscar A.¹⁰⁹  Lorenzatti, Alberto J.¹¹⁰  Cartasegna, Luis R.^111,112  Paterlini, Gustavo A.¹¹³  Mackinnon, Ignacio J.¹¹⁴  Caime, Guillermo D.¹¹⁵  Amuchastegui, Marcos¹¹⁶  Salomone, Rodolfo¹¹⁶  Codutti, Oscar R.¹¹⁷  Jure, Horacio O.¹¹⁸  Bono, Julio O. E.¹¹⁹  Hrabar, Adrian D.¹²⁰  Vallejos, Julio A.¹²¹  Ahuad Guerrero, Rodolfo A.¹²²  Novoa, Federico¹²³  Patocchi, Cristian A.¹²⁴  Zaidman, Cesar J.¹²⁵  Giuliano, Maria E.¹²⁶  Dran, Ricardo D.¹²⁷  Vico, Marisa L.¹²⁸  Carnero, Gabriela S.¹²⁹  Guzman, Pablo N.¹³⁰  Medrano Allende, Juan C.¹³¹  Garcia Brasca, Daniela F.¹³²  Bustamante Labarta, Miguel H.¹³³  Nani, Sebastian¹³⁴  Blumberg, Eduardo D. S.¹³⁵  Colombo, Hugo R.¹³⁶  Liberman, Alberto¹³⁷  Luciardi, Hector L.¹³⁸  Waisman, Gabriel D.¹³⁹  Berli, Mario A.¹⁴⁰  Duran, Ruben O. Garcia¹⁴¹  Cestari, Horacio G.¹⁴²  Luquez, Hugo A.¹⁴³  Giordano, Jorge A.¹⁴⁴  Saavedra, Silvia S.¹⁴⁵  Zapata, Gerardo¹⁴⁶  Costamagna, Osvaldo¹⁴⁷  Llois, Susana¹⁴⁸  Waites, Jonathon H.¹⁴⁹  Collins, Nicholas¹⁵⁰  Soward, Allan¹⁵¹  Aylward, Philip E.^25,152  Hii, Chris L. S.¹⁵³  Shaw, James¹⁵⁴  Arstall, Margaret A.¹⁵⁵  Horowitz, John¹⁵⁶  Rogers, James F.¹⁵⁷  Colquhoun, David¹⁵⁸  Oqueli Flores, Romulo E.¹⁵⁹  Roberts-Thomson, Philip¹⁶⁰  Raffel, Owen¹⁶¹  Lehman, Sam J.¹⁶²  Aroney, Constantine¹⁶³  Coverdale, Steven G. M.¹⁶⁴  Garrahy, Paul J.¹⁶⁵  Starmer, Gregory¹⁶⁶  Sader, Mark¹⁶⁷  Carroll, Patrick A.¹⁶⁸  Dick, Ronald¹⁶⁹  Zweiker, Robert¹⁷⁰  Hoppe, Uta¹⁷¹  Huber, Kurt¹⁷³  Berger, Rudolf¹⁷⁴  Weidinger, Franz¹⁷⁵  Faes, Dirk¹⁷⁶  Hermans, Kurt¹⁷⁷  Pirenne, Bruno¹⁷⁸  Leone, Attilio¹⁷⁹  Hoffer, Etienne¹⁸⁰  Vrolix, Mathias C. M.¹⁸¹  De Wolf, Luc¹⁸²  Wollaert, Bart¹⁸³  Castadot, Marc¹⁸⁴  Dujardin, Karl¹⁸⁵  Beauloye, Christophe¹⁸⁶  Vervoort, Geert¹⁸⁷  Striekwold, Harry¹⁸⁸  Convens, Carl¹⁸⁹  Roosen, John¹⁹⁰  Barbato, Emanuele¹⁹¹  Claeys, Marc¹⁹²  Cools, Frank¹⁹³  Terzic, Ibrahim¹⁹⁴  Barakovic, Fahir¹⁹⁵  Midzic, Zlatko¹⁹⁶  Pojskic, Belma¹⁹⁷  Fazlibegovic, Emir¹⁹⁸  Durak-Nalbantic, Azra²⁸  Vulic, Dusko¹⁹⁹  Muslibegovic, Adis²⁰⁰  Goronja, Boris¹⁹⁹  Reis, Gilmar²⁰¹  Sousa, Luciano²⁰²  Nicolau, Jose C.²⁰³  Giorgeto, Flavio E.²⁰⁴  Silva, Ricardo P.²⁰⁵  Maia, Lilia Nigro²⁰⁶  Rech, Rafael²⁰⁷  Rossi, Paulo R. F.²⁰⁸  Cerqueira, Maria Jose A. G.²⁰⁹  Duda, Norberto²¹⁰  Kalil, Renato²¹¹  Kormann, Adrian²¹²  Abrantes, Jose Antonio M.²¹³  Pimentel Filho, Pedro²¹⁴  Soggia, Ana Priscila²¹⁵  de Santos, Mayler O. N.²¹⁶  Neuenschwander, Fernando²¹⁷  Bodanese, Luiz C.²¹⁸  Michalaros, Yorghos L.²¹⁹  Eliaschewitz, Freddy G.²²⁰  Vidotti, Maria H.²²¹  Leaes, Paulo E.²²²  Botelho, Roberto V.²²³  Kaiser, Sergio²²⁴  Fernandes Manenti, Euler Roberto F.²²⁵  Precoma, Dalton B.²²⁶  Moura Jorge, Jose C.²²⁷  Silva, Pedro G. M. de B.²²⁸  Silveira, Jose A.²²⁹  Saporito, Wladmir^230,239  Marin Neto, Jose A.²³¹  Feitosa, Gilson S.²³²  Ritt, Luiz Eduardo F.²³³  de Souza, Juliana A.²³⁴  Costa, Fernando²³⁵  Souza, Weimar K. S. B.²³⁶  Reis, Helder J. L.²³⁷  Machado, Leandro²³⁹  Aidar Ayoub, Jose Carlos²⁴⁰  Todorov, Georgi V.²⁴¹  Nikolov, Fedya P.²⁴²  Velcheva, Elena S.²⁴³  Tzekova, Maria L.²⁴⁴  Benov, Haralambi O.²⁴⁵  Petranov, Stanislav L.²⁴⁶  Tumbev, Haralin S.²⁴⁷  Shehova-Yankova, Nina S.²⁴⁸  Markov, Dimitar T.²⁴⁹  Raev, Dimitar H.²⁵⁰  Mollov, Mihail N.²⁵¹  Kichukov, Kostadin N.²⁵²  Ilieva-Pandeva, Katya A.²⁵³  Ivanova, Raya²⁵⁴  Mincheva, Valentina M.²⁵⁵  Lazov, Petar V.²⁵⁶  Dimov, Bojidar I.²⁵⁷  Senaratne, Manohara²⁵⁸  Stone, James²⁵⁹  Pearce, Stephen²⁶⁰  Dion, Danielle²⁶¹  Savard, Daniel²⁶²  Pesant, Yves²⁶³  Pandey, Amritanshu²⁶⁴  Robinson, Simon²⁶⁵  Gosselin, Gilbert²⁶⁶  Vizel, Saul²⁶⁷  Hoag, Gordon²⁶⁸  Bourgeois, Ronald²⁶⁹  Morisset, Anne²⁷⁰  Sabbah, Eric²⁷¹  Sussex, Bruce²⁷²  Kouz, Simon²⁷³  MacDonald, Paul²⁷⁴  Diaz, Ariel²⁷⁵  Michaud, Nicolas²⁷⁶  Fell, David²⁷⁷  Leung, Raymond²⁷⁸  Vuurmans, Tycho²⁷⁹  Lai, Christopher²⁸⁰  Nigro, Frank²⁸⁰  Davies, Richard²⁸¹  Nogareda, Gustavo²⁸²  Vijayaraghavan, Ram²⁸³  Ducas, John²⁸⁴  Lepage, Serge²⁸⁵  Mehta, Shamir²⁸⁶  Cha, James²⁸⁷  Dupuis, Robert²⁸⁸  Fong, Peter²⁸⁹  Rodes-Cabau, Josep²⁹⁰  Fadlallah, Hussein²⁹¹  Cleveland, David²⁹²  Thao Huynh²⁹³  Bata, Iqbal²⁹⁴  Hameed, Adnan²⁹⁵  Pincetti, Cristian²⁹⁶  Potthoff, Sergio²⁹⁷  Prieto, Juan C.^16,298  Acevedo, Monica²⁹⁹  Aguirre, Arnoldo³⁰⁰  Vejar, Margarita³⁰¹  Yanez, Mario³⁰²  Araneda, Guillermo³⁰³  Fernandez, Mauricio³⁰⁴  Perez, Luis³⁰⁵  Varleta, Paola³⁰⁶  Florenzano, Fernando³⁰⁷  Huidobro, Laura³⁰⁸  Raffo, Carlos A.³⁰⁹  Olivares, Claudia³¹⁰  Nahuelpan, Leonardo³¹¹  Montecinos, Humberto³¹²  Chen, Jiyan³¹³  Dong, Yugang³¹⁴  Huang, Weijian³¹⁵  Wang, Jianzhong³¹⁶  Huang, Shi'An³¹⁷  Yao, Zhuhua³¹⁸  Li, Xiang³¹⁹  Cui, Lan³¹⁹  Lin, Wenhua³²⁰  Sun, Yuemin³²¹  Wang, Jingfeng³²²  Li, Jianping³²³  Zhang, Xuelian³²⁴  Zhu, Hong³²⁵  Chen, Dandan³²⁶  Huang, Lan³²⁷  Dong, Shaohong³²⁸  Su, Guohai³²⁹  Xu, Biao³³⁰  Su, Xi³³¹  Cheng, Xiaoshu³³²  Lin, Jinxiu³³³  Zong, Wenxia³³⁴  Li, Huanming³³⁵  Feng, Yi³³⁶  Xu, Dingli³³⁷  Yang, Xinchun³³⁸  Ke, Yuannan³³⁹  Lin, Xuefeng³⁴⁰  Zhang, Zheng³⁴¹  Zheng, Zeqi³⁴²  Luo, Zhurong³⁴³  Chen, Yundai³⁴⁴  Ding, Chunhua³⁴⁵  Zheng, Yang³⁴⁶  Li, Xiaodong³⁴⁷  Peng, Daoquan³⁴⁸  Li, Ying³⁴⁹  Wei, Meng³⁵⁰  Liu, Shaowen³⁵¹  Yu, Yihua³⁵²  Qu, Baiming³⁵³  Jiang, Weihong³⁵⁴  Zhou, Yujie³⁵⁵  Zhao, Xingsheng³⁵⁶  Yuan, Zuyi³⁵⁷  Guo, Ying³⁵⁸  Xu, Xiping³⁵⁹  Shi, Xubo³⁶⁰  Ge, Junbo³⁶¹  Fu, Guosheng³⁶²  Bai, Feng³⁶³  Fang, Weiyi³⁶⁴  Shou, Xiling³⁶⁵  Yang, Xiangjun³⁶⁶  Wang, Jian'An³⁶⁷  Sun, Yingxian³⁶⁸  Lu, Qinghua³⁶⁹  Zhang, Ruiyan³⁷⁰  Zhu, Jianhua³⁷¹  Xu, Yizhou³⁷²  Fan, Zhongcai³⁷³  Li, Tianchang³⁷⁴  Wu, Chun³⁷⁵  Jaramillo, Nicolas³⁷⁶  Vallejo, Gregorio Sanchez³⁷⁷  Botia, Diana C. Luna³⁷⁸  Lopez, Rodrigo Botero³⁷⁹  De Salazar, Dora I. Molina³⁸⁰  Bonfanti, Alberto J. Cadena³⁸¹  Higuera, Juan Diego³⁸²  Silva, Sandra I. Barrera³⁸³  Lozada, Henry J. Garcia³⁸⁴  Arroyo, Julian A. Coronel³⁸⁵  Mendoza, Jose L. Accini³⁸⁶  Ruiz, Ricardo L. Fernandez³⁸⁷  Jatin, Fernando G. Manzur³⁸⁸  Herazo, Aristides Sotomayor³⁸⁹  Parada, Jeffrey Castellanos³⁹⁰  Triana, Miguel A. Urina³⁹¹  Strozzi, Maja³⁹²  Car, Sinisa³⁹³  Milicic, Davor³⁹⁴  Bencic, Martina Lovric³⁹²  Pintaric, Hrvoje³⁹⁵  Prvulovic, Deiti³⁹⁶  Sikic, Jozica³⁹⁷  Persic, Viktor³⁹⁸  Mileta, Dean³⁹⁹  Stambuk, Kresimir⁴⁰⁰  Zdravko, Babic⁴⁰¹  Tomulic, Vjekoslav⁴⁰²  Krstulovic, Stanka Mejic⁴⁰³  Starcevic, Boris⁴⁰⁴  Spinar, Jindrich⁴⁰⁵  Horak, David⁴⁰⁶  Stasek, Josef⁴⁰⁷  Alan, David⁴⁰⁸  Machova, Vilma⁴⁰⁹  Linhart, Ales⁴¹⁰  Novotny, Vojtech⁴¹¹  Kaucak, Vladimir⁴¹²  Rokyta, Richard⁴¹³  Naplava, Robert⁴¹⁴  Coufal, Zdenek⁴¹⁵  Adamkova, Vera⁴¹⁶  Podpera, Ivo⁴¹⁷  Zizka, Jiri⁴¹⁸  Motovska, Zuzana⁴¹⁹  Marusincova, Ivana⁴²⁰  Svab, Premysl⁴²¹  Ostadal, Petr^35,422  Heinc, Petr⁴²³  Marx, Nikolaus⁴¹  Liberopoulos, Evangelos⁴²  Valdovinos, Pablo Carlos Montenegro⁴³  Kiss, Robert Gabor⁴⁵  Kimura, Takeshi⁴⁹  Kim, Sang-Hyun⁵¹  Kedev, Sasko⁵²  Yusoff, Khalid^55,56  Gullestad, Lars⁵⁹  Halvorsen, Sigrun⁵⁹  Sy, Rody G.⁶⁰  Budaj, Andrzej⁶¹  Morais, Joao⁶²  Dorobantu, Maria⁶³  Karpov, Yuri^14,64  Ristic, Arsen D.⁶⁵  Tunon Fernandez, Jose⁷⁰  Muller, Christian⁷³  Lopes, Renato⁹¹  Egydio, Flavia⁹¹  Kawakami, Anelise⁹¹  Oliveira, Janaina⁹¹  Matthews, Alexander¹⁰  Ratky, Caroline¹⁰  Valiris, Janine¹⁰  Berdan, Lisa⁸⁰  Hepditch, Anita⁸⁰  Quintero, Kirby⁸⁰  Rorick, Tyrus⁸⁰  Westbrook, Melissa⁸⁰  Hagstrom, Emil⁷²  Bregeault, Marie-France¹²  Bougon, Nathalie¹²  Faustino, Douglas¹²  Fontecave, Sylvie¹²  Murphy, Judith¹²  Tamby, Jean-Francois¹²  Verrier, Melanie¹²  Agnetti, Veronique¹²  Andersen, Dorthe¹²  Badreddine, Emmy¹²  Bekkouche, Mhamed¹²  Bouancheau, Cecile¹²  Brigui, Imane¹²  Brocklehurst, Maddy¹²  Cianciarulo, Joseph¹²  Devaul, Dawn¹²  Domokos, Szilvia¹²  Gache, Cecile¹²  Gobillot, Caroline¹²  Guillou, Severine¹²  Healy, Jan¹²  Heath, Megan¹²  Jaiwal, Gayatri¹²  Javierre, Carine¹²  Labeirie, Julien¹²  Monier, Myriam¹²  Morales, Ulises¹²  Mrabti, Asmaa¹²  Mthombeni, Bicky¹²  Okan, Betim¹²  Smith, Lucile¹²  Sheller, Jennifer¹²  Sopena, Sebastien¹²  Pellan, Valerie¹²  Benbernou, Fadela¹²  Bengrait, Nafissa¹²  Lamoureux, Maud¹²  Kralova, Katarina¹²  Scemama, Michel¹²  Bejuit, Raphael¹²  Coulange, Anthony¹²  Berthou, Christelle¹²  Repincay, Jerome¹²  Lorenzato, Christelle¹²  Etienne, Alexis¹²  Gouet, Valerie¹²  Loizeau, Virginie¹²  Normand, Mickael¹²  Ourliac, Anne¹²  Rondel, Christelle¹²  Adamo, Antony¹²  Beltran, Pascale¹²  Barraud, Pauline¹²  Dubois-Gache, Helene¹²  Halle, Benjamin¹²  Metwally, Lamia¹²  Mourgues, Maxime¹²  Sotty, Marc¹²  Vincendet, Marion¹²  Cotruta, Raluca¹²  Zhu Chengyue¹²  Fournie-Lloret, Dominique¹²  Morrello, Christine¹²  Perthuis, Aurelie¹²  Picault, Patrick¹²  Zobouyan, Isabelle¹² 

[1] Leiden Univ, Dept Cardiol, Med Ctr, POB 9600, NL-2300 RC Leiden, Netherlands

[2] SUNY, Downstate Sch Publ Hlth, Brooklyn, NY USA

[3] Univ Kelaniya, Fac Med, Clin Trials Unit, Kelaniya, Sri Lanka

[4] Brigham & Womens Hosp, Heart & Vasc Ctr, 75 Francis St, Boston, MA 02115 USA

[5] Harvard Med Sch, Boston, MA 02115 USA

[6] Univ Alabama Birmingham, Div Cardiovasc Dis, Birmingham, AL 35294 USA

[7] Cardiovasc Inst Rosario, Latinoamer Cardiol Studies, Rosario, Santa Fe, Argentina

[8] Sanofi, Bridgewater, NJ USA

[9] Univ Alberta, Canadian VIGOUR Ctr, Edmonton, AB, Canada

[10] Covance, Marlow, Bucks, England

[11] Univ Toronto, St Michaels Hosp, Toronto, ON, Canada

[12] Sanofi, Paris, France

[13] Stanford Univ, Dept Med, Stanford Ctr Clin Res, Stanford, CA 94305 USA

[14] Russian Cardiol Sci Product Complex, Moscow, Russia

[15] Regeneron Pharmaceut Inc, Tarrytown, NY USA

[16] Univ Chile Clin Hosp, Santiago, Chile

[17] Duke Univ, Med Ctr, Duke Clin Res Inst, Durham, NC USA

[18] Duke Univ, Sch Med, Dept Med, Div Cardiol, Durham, NC 27706 USA

[19] Auckland City Hosp, Green Lane Cardiovasc Serv, Auckland, New Zealand

[20] Goethe Univ, Dept Med 3, Frankfurt, Germany

[21] Univ Colorado, Sch Med, Div Cardiol, Aurora, CO USA

[22] Hop Bichat Claude Bernard, AP HP, Paris, France

[23] Paris Diderot Univ, Sorbonne Paris Cite, FACT, INSERM U1148, Paris, France

[24] Royal Brompton Hosp, Imperial Coll, Natl Heart & Lung Inst, London, England

[25] Flinders Univ S Australia, South Australian Hlth & Med Res Inst, Med Ctr, Adelaide, SA, Australia

[26] Landeskrankenhaus Feldkirch, Feldkirch, Austria

[27] UZ Leuven, Leuven, Belgium

[28] Univ Clin Ctr Sarajevo, Sarajevo, Bosnia & Herceg

[29] MHAT Nat Cardiol Hosp EAD, Sofia, Bulgaria

[30] Univ Chile, Hosp Clin, Santiago, Chile

[31] Peking Univ, First Hosp, Beijing, Peoples R China

[32] Fundac Oftalmol Santander FOSCAL, Floridablanca, Colombia

[33] Univ Zagreb, Univ Hosp Ctr Zagreb, Zagreb Sch Med, Zagreb, Croatia

[34] Univ Zagreb, Univ Ctr Zagreb, Sch Med, Zagreb, Croatia

[35] Na Homolce Hosp, Prague, Czech Republic

[36] Aarhus Univ Skejby, Aarhus, Denmark

[37] North Estonia Med Ctr, Tallinn, Estonia

[38] Heart & Lung Ctr, Div Cardiol, HUCH, Helsinki, Finland

[39] Hop Europeen Georges Pompidou, FACT, F CRIN Network, Paris, France

[40] Chapidze Emergency Cardiol Ctr, Tbilisi, Georgia

[41] Univ Aachen, Aachen, Germany

[42] Univ Gen Hosp Ioannina, Ioannina, Greece

[43] Unidad Diagnost Cardiol, Clin Privada, Guatemala City, Guatemala

[44] Univ Hong Kong, Queen Mary Hosp, Hong Kong, Peoples R China

[45] Magyar Honvedseg Egeszsegugyi Kozpont, Budapest, Hungary

[46] St Johns Med Coll, Bangalore, Karnataka, India

[47] Ben Gurion Univ Negev, Soroka Univ Med Ctr, Fac Hlth Sci, Beer Sheva, Israel

[48] Univ Ferrara, Unit Operativa Cardiologia, Ferrara, Italy

[49] Kyoto Univ, Grad Sch Med, Kyoto, Kyoto, Japan

[50] Seoul Natl Univ Hosp, Seoul, South Korea

[51] SMG Seoul Natl Univ, Boramae Med Ctr, Seoul, South Korea

[52] Univ Clin Cardiol, Skopje, North Macedonia

[53] Univ Latvia, Pauls Stradins Clin Univ Hosp, Riga, Latvia

[54] Vilnius Univ Hosp Santaros Klinikos, Vilnius, Lithuania

[55] Univ Teknol MARA UiTM Selayang Campus, Batu Caves, Malaysia

[56] UCSI Univ, Kuala Lumpur, Malaysia

[57] Med Off, Guadalajara, Jalisco, Mexico

[58] Amphia Ziekenhuis Molengracht, Breda, Netherlands

[59] Oslo Univ HF, Oslo, Norway

[60] Cardinal Santos Med Ctr, San Juan, PR USA

[61] Grochowski Hosp, Postgrad Med Sch, Warsaw, Poland

[62] Ctr Hosp Leiria Pombal, Leiria, Portugal

[63] Clin Emergency Hosp Bucharest, Bucharest, Romania

[64] Russian Cardiol Sci Prod Complex, Moscow, Russia

[65] Clin Ctr Serbia, Belgrade, Serbia

[66] Natl Heart Ctr, Singapore, Singapore

[67] Univ Nemocn Bratislava, Interna Klin 1, Bratislava, Slovakia

[68] Univ Med Ctr Ljubljana, Div Med, Dept Vasc Med, Prevent Cardiol Unit, Ljubljana, Slovenia

[69] Milpark Hosp, Johannesburg, South Africa

[70] Fdn Jimenez Diaz, Madrid, Spain

[71] Univ Kelaniya, Clin Trials Unit, Kelaniya, Sri Lanka

[72] Uppsala Univ, Dept Med Sci, Uppsala Clin Res Ctr, Uppsala, Sweden

[73] Univ Basel, Basel, Switzerland

[74] Natl Yang Ming Univ, Taipei Vet Gen Hosp, Gen Clin Res Ctr, Taipei, Taiwan

[75] Ramathibodi Hosp, Bangkok, Thailand

[76] Dokuz Eylul Univ Tip Fakultesi, Izmir, Turkey

[77] MD Strazhesko Inst Cardiol AMS Ukraine, Kiev, Ukraine

[78] Imperial Coll London, London, England

[79] Univ Kansas, Med Ctr, Clin Pharmacol, Kansas City, KS USA

[80] Duke Clin Res Inst, Durham, NC USA

[81] Univ Colorado Denver, Denver, CO USA

[82] St Louis Univ, Ctr Hlth Outcomes Res, St Louis, MO USA

[83] Univ Pittsburgh, Grad Sch Publ Hlth, Pittsburgh, PA USA

[84] Linkoping Univ, Dept Med & Hlth, Linkoping, Sweden

[85] Univ Montreal, Inst Cardiol, Montreal, PQ, Canada

[86] Erasmus MC, Rotterdam, Netherlands

[87] Duke Univ, Duke Clin Res Inst, Durham, NC USA

[88] Mt Sinai Sch Med, New York, NY USA

[89] Duke Univ, Durham, NC USA

[90] Stanford Univ, Stanford, CA 94305 USA

[91] Brazilian Clin Res Inst, Sao Paulo, Brazil

[92] Univ N Carolina, Chapel Hill, NC USA

[93] Fdn IRCCS Policlin S Matteo, Pavia, Italy

[94] Hop Europeen Georges Pompidou, Paris, France

[95] Univ British Columbia, St Pauls Hosp, Vancouver, BC, Canada

[96] Clin Prado, Cordoba, Argentina

[97] Clin Privada Prov, Merlo, Buenos Aires, DF, Argentina

[98] Ctr Invest Med Mar Plata, Mar Del Plata, Buenos Aires, Argentina

[99] Consultorios Asoc Endocrinol Inv Clin Aplicad, CABA, Buenos Aires, DF, Argentina

[100] Clin FUSAVIM Privada, Cordoba, Argentina

[101] Inst Cardiovasc Buenos Aires Ciudad Buenos Aires, Buenos Aires, DF, Argentina

[102] Inst Med Aguero, Moron, Buenos Aires, DF, Argentina

[103] Fdn Favaloro Docencia Invest Med, CABA, Buenos Aires, DF, Argentina

[104] Hosp Cent Mendoza, Mendoza, Argentina

[105] Sanatorio Santa Rosa, Santa Rosa, La Pampa, Argentina

[106] Ctr Invest Clin Iitoral, Santa Fe, Santa Fe, Argentina

[107] Dim Clin Privada, Ramos Mejia, Buenos Aires, DF, Argentina

[108] Clin Coronel Suarez, Coronel Suarez, Buenos Aires, DF, Argentina

[109] Sanatorio San Martin SA, Venado Tuerto, Santa Fe, NM USA

[110] Inst Med DAMIC, Cordoba, Argentina

[111] Hosp Italiano Plata, La Plata, Buenos Aires, Argentina

[112] Hosp Italiano La Plata, La Plata, Buenos Aires, Argentina

[113] Invest Clin Tucuman, San Miguel De Tucuman, Tucuman, Argentina

[114] Inst Invest Clin, Mar Del Plata, Buenos Aires, Argentina

[115] Inst Diagnost La Plata, La Plata, Buenos Aires, Argentina

[116] Hosp Privado Ctr Med Cordoba, Cordoba, Argentina

[117] Cordis Inst Corazon, Resistencia, Chaco, Argentina

[118] Clin Chutro SRL, Cordoba, Argentina

[119] Sanatorio Allende, Cordoba, Argentina

[120] Inst Invest Clin Quilmes, Quilmes, Buenos Aires, Argentina

[121] Inst Cardiol Corrientes, Corrientes, Argentina

[122] Corporac Med San Martin, San Martin, Buenos Aires, Argentina

[123] Consultorio Privado, San Isidro, Buenos Aires, Argentina

[124] Hosp Reg Espanol Bahia Blanca, Bahia Blanca, Buenos Aires, Argentina

[125] Ctr Invest Prevenc Cardiovasc, Caba, Buenos Aires, Argentina

[126] Inst Med Fdn Estudios Clin, Rosario, Santa Fe, Argentina

[127] Sanatorio Mariano Pelliza, Olivos, Buenos Aires, Argentina

[128] Inst Invest Clin Zarate, Zarate, Buenos Aires, Argentina

[129] IMEP Inst Med Elsa Perez, Ciudadela, Buenos Aires, Argentina

[130] Sanatorio San Francisco, Santiago Del Estero, Argentina

[131] Clin Maternidad Suizo Argentina, Caba, Buenos Aires, Argentina

[132] Hosp Italiano, Cordoba, Argentina

[133] Ctr Med Lebensohn, Buenos Aires, DF, Argentina

[134] Clin Olivos, Buenos Aires, DF, Argentina

[135] Medeos, Caba, Buenos Aires, Argentina

[136] Clin Colombo, Cordoba, Argentina

[137] Inst Privado Invest Clin Cordoba, Cordoba, Argentina

[138] Ctr Modelo Cardiol, San Miguel De Tucuman, Tucuman, Argentina

[139] Hosp Italiano Buenos Aires, Buenos Aires, DF, Argentina

[140] Hosp Prov Dr Jose Maria Cullen, Santa Fe, Santa Fe, Argentina

[141] Inst Invest Clin San Nicolas, San Nicolas, Buenos Aires, Argentina

[142] Sanatorio Guemes, Caba, Buenos Aires, Argentina

[143] Ctr Med Luquez, Cordoba, Argentina

[144] Clin Inst Med Adrogue, Almirante Brown, Buenos Aires, Argentina

[145] Sanatorio Parque SA, Salta, Argentina

[146] Inst Cardiovasc Rosario, Rosario, Santa Fe, Argentina

[147] Clin Parra Ctr Invest Clin Rafaela, Santa Fe, Argentina

[148] Hosp Interzonal Gen Agudos Eva Peron, San Martin, Buenos Aires, Argentina

[149] Coffs Harbour Hlth Campus, Coffs Harbour, NSW, Australia

[150] John Hunter Hosp, New Lambton Hts, NSW, Australia

[151] Mildura Cardiol, Mildura, Vic, Australia

[152] South Australian Hlth & Med Res Inst, Flinders Univ & Med Ctr, Adelaide, SA, Australia

[153] Calvary Clin, Bruce, Australia

[154] Alfred Hosp, Prahran, Vic, Australia

[155] Northern Cardiol & Specialist Clin, Elizabeth Vale, Australia

[156] Queen Elizabeth Hosp, Woodville, SA, Australia

[157] Gosford Hosp, Gosford, Australia

[158] Wesley Med Ctr, Auchenflower, QLD, Australia

[159] Ballarat Hlth Serv, Ballarat, Vic, Australia

[160] Royal Hobart Hosp, Hobart, Tas, Australia

[161] Prince Charles Hosp, Chermside, Qld, Australia

[162] Adelaide Med Res, Adelaide, SA, Australia

[163] Holy Spirit Northside Hosp, Chermside, Qld, Australia

[164] Nambour Gen Hosp, Nambour, Qld, Australia

[165] Princess Alexandra Hosp, Woolloongabba, Qld, Australia

[166] Cairns Hosp, Cairns, Qld, Australia

[167] St George Hosp, Kogarah, NSW, Australia

[168] Redcliffe Hosp, Redcliffe, Qld, Australia

[169] Epworth Healthcare, Richmond, Vic, Australia

[170] Univ Klinikum Graz, Graz, Austria

[171] Univ Klinikum Salzburg, Salzburg, Austria

[172] Vorarlberg Inst Vaskulare Forsch VIVIT, Feldkirch, Austria

[173] Wilhelminenspital Stadt Wien, Vienna, Austria

[174] KH Barmherzigen Bruder Eisenstadt, Kardiol & Nephrol, Eisenstadt, Austria

[175] Krankenanstalt Rudolfstiftung Stadt Wien, Vienna, Austria

[176] Mariaziekenhuis Vzw, Overpelt, Belgium

[177] AZ St Lucas, Ghent, Belgium

[178] Clin St Pierre, Ottignies, Belgium

[179] CHU Tivoli, La Louviere, Belgium

[180] CHR Citadelle, Liege, Belgium

[181] ZOL, Genk, Belgium

[182] Private Practice, Tienen, Belgium

[183] ZNA Stuivenberg, Antwerp, Belgium

[184] Clin St Jean, Brussels, Belgium

[185] AZ Delta, Roeselare, Belgium

[186] UCL St Luc, Brussels, Belgium

[187] AZ St Maarten, Mechelen, Belgium

[188] Heilig Hart Ziekenhuis, Mol, Belgium

[189] ZNA Middelheim, Antwerp, Belgium

[190] Imelda Hosp, Bonheiden, Belgium

[191] OL Vrouwziekenhuis Campus Aalst, Aalst, Belgium

[192] UZ Antwerpen, Edegem, Belgium

[193] AZ Klina, Brasschaat, Belgium

[194] Heart Ctr BH, Tuzla, Bosnia & Herceg

[195] Univ Med Ctr Tuzla, Tuzla, Bosnia & Herceg

[196] Cantonal Hosp Dr Irfan Ljubijank Bihac, Bihac, Bosnia & Herceg

[197] Cantonal Hosp Zenica, Zenica, Bosnia & Herceg

[198] Univ Clin Hosp Mostar, Mostar, Bosnia & Herceg

[199] Clin Ctr Banja Luka, Banja Luka, Bosnia & Herceg

[200] Reg Med Ctr Dr Safet Mujic, Mostar, Bosnia & Herceg

[201] CARDRESEARCH Cardiol Assistencial Pesquisa, Belo Horizonte, MG, Brazil

[202] Hosp Coracao Brasil, Brasilia, DF, Brazil

[203] INCOR Inst Coracao, Sao Paulo, Brazil

[204] Hosp Sao Francisco De Assis, Belo Horizonte, MG, Brazil

[205] Hosp Univ Walter Cantidio, Fortaleza, Ceara, Brazil

[206] Hosp Base Sao Jose do Rio Preto, Sao Paulo, Brazil

[207] Hosp Univ Ulbra, Canoas, Brazil

[208] Hosp Evangelico Curitiba, Curitiba, Parana, Brazil

[209] Inst Ensino Pesquisa Clin Ceara Ltda, Fortaleza, Ceara, Brazil

[210] Hosp Sao Vicente De Paulo, Passo Fundo, RS, Brazil

[211] Inst Cardiol Do Rio Grande Do Sul, Porto Alegre, RS, Brazil

[212] Hosp Santa Isabel, Soc Div Providencia, Blumenau, Santa Catarina, Brazil

[213] Santa Casa Misericordia Pelotas, Pelotas, RS, Brazil

[214] Hosp Nossa Senhora Conceicao, Porto Alegre, RS, Brazil

[215] Soc Beneficiente Senhoras Hosp Sirio Libane, Sao Paulo, Brazil

[216] Ctr Cardiol & Radiol Intervencionista LTDA, Aparecida Goiania, Brazil

[217] Hosp Vera Cruz NUPEC, Belo Horizonte, MG, Brazil

[218] Hosp Sao Lucas PUCRS, Porto Alegre, RS, Brazil

[219] Inst Ensino Consultoria & Pesquisa Clin LTDA ME, Belo Horizonte, MG, Brazil

[220] CPCLIN, Sao Paulo, Brazil

[221] Clin LOEMA, Campinas, Brazil

[222] Santa Casa Porto Alegre, Porto Alegre, RS, Brazil

[223] Inst Coracao Triangulo, Uberlandia, MG, Brazil

[224] CCBR Brasil, Rio De Janeiro, Brazil

[225] IMV Inst Med Vasc Hosp Mae Deus, Porto Alegre, RS, Brazil

[226] Soc Hosp Angelina Caron, Campina Grande Do Sul, Parana, Brazil

[227] Santa Casa Curitiba, Curitiba, Parana, Brazil

[228] Esho Empresa Serv Hosp SA, Sao Paulo, Brazil

[229] Fac Med ABC CEMEC, Sao Bernardo Campo, Sao Paulo, Brazil

[230] Inst Molestias Cardiovasc Tatui IMC, Tatui, Brazil

[231] HCFMRP, Ribeirao Preto, Brazil

[232] Hosp Santa Izabel, Santa Casa Misericordia Bahia, Salvador, BA, Brazil

[233] Hosp Cardio Pulmonar, Salvador, BA, Brazil

[234] Ctr Cardiol Clin & Pesquisa Dra Juliana Souza, Brasilia, DF, Brazil

[235] FGM Clin Paulista Doencas Cardiovasc, Sao Paulo, Brazil

[236] Barroso & Sebba Ltda, Goiania, Go, Brazil

[237] Hosp Clin Gaspar Vianna, Belem, Para, Brazil

[238] Univ Fed Sao Paulo UNIFESP EPM, Sao Paulo, Brazil

[239] Hosp Estadual Mario Covas, Santo Andre, Brazil

[240] Inst Molestias Cardiovasc, Sao Jose Do Rio Preto, Brazil

[241] 2 MHAT, Sofia, Bulgaria

[242] Univ Multiprofile Hosp Act Treatment Sveti Georgi, Plovdiv, Bulgaria

[243] Specialized Hosp Act Treatment Cardiol, Pleven, Bulgaria

[244] UMHAT Dr Georgi Stranski, Pleven, Bulgaria

[245] Multiprof Distr Hosp Active Treatment Dr St Cherk, Veliko Tarnovo, Bulgaria

[246] Multiprofile Hosp Act Treatment Burgas AD, Burgas, Bulgaria

[247] Specialized Hosp Act Cardio Treatment Cardiolife, Varna, Bulgaria

[248] MHAT Bratan Shukerov AD, Cardio Dept Inrtens Unite, Smoljan, Bulgaria

[249] UMHAT Tzaritza Yoanna ISUL EAD, Sofia, Bulgaria

[250] MHAT Sveti Vrach EOOD, Sandanski, Bulgaria

[251] First Multiprofile Hosp Act Treatment Sofia EAD, Sofia, Bulgaria

[252] MHAT Lyulin EAD, Dept Internal Dis, Sofia, Bulgaria

[253] MHAT Blagoevgrad AD, Blagoevgrad, Bulgaria

[254] UMHAT Alexandrovska EAD, Sofia, Bulgaria

[255] NMT Hosp Tsar Boris III, Sofia, Bulgaria

[256] Multiprofile Hosp Act Treatment Pazardzhik AD, Pazardzhik, Bulgaria

[257] Fifth MHAT Sofia EAD, Sofia, Bulgaria

[258] Dr MPJ Senaratne Profess Corp, Edmonton, AB, Canada

[259] TotalCardiology, Calgary, AB, Canada

[260] Surrey Mem Hosp, Surrey, BC, Canada

[261] Ctr Hosp Beauce Etchemin, St Georges De Beauce, PQ, Canada

[262] CardioVasc HR, St Jean, PQ, Canada

[263] St Jerome Med Res Inc, St Jerome, PQ, Canada

[264] Cambridge Cardiac Care Ctr, Cambridge, ON, Canada

[265] Victoria Heart Inst Fdn, Victoria, BC, Canada

[266] Ctr Hosp Pierre Gardeur, Terrebonne, PQ, Canada

[267] Vizel Cardiac Res, Cambridge, ON, Canada

[268] Discovery Clin Serv, Victoria, BC, Canada

[269] GA Res Associates Ltd, Moncton, NB, Canada

[270] Ctr Sante & Serv Soc Haute Yamaska, Granby, PQ, Canada

[271] Ctr Depistage & Rech Cardiovasc Rive Sud, Longueuil, PQ, Canada

[272] Gen Hosp Hlth Sci Ctr, St John, NF, Canada

[273] Ctr Hosp Reg Lanaudiere, Joliette, PQ, Canada

[274] Cape Breton Reg Hosp, Sydney, NS, Canada

[275] Ctr Hosp Reg Trois Rivieres, Trois Rivieres, PQ, Canada

[276] Clin Cardiol Levis, Levis, PQ, Canada

[277] Newmarket Cardiol Res Grp, Newmarket, ON, Canada

[278] Royal Alexandra Hosp, Edmonton, AB, Canada

[279] Royal Columbian Hosp, New Westminster, BC, Canada

[280] Thunder Bay Reg Hlth Sci Ctr, Thunder Bay, ON, Canada

[281] Ottawa Heart Inst, Ottawa, ON, Canada

[282] Red Deer Reg Hosp Ctr, Red Deer, AB, Canada

[283] Scarborough Cardiol Res, Scarborough, ON, Canada

[284] St Boniface Gen Hosp, Winnipeg, MB, Canada

[285] Ctr Hosp Univ Sherbrooke, Hotel Dieu, Sherbrooke, PQ, Canada

[286] Hamilton Gen Hosp, Hamilton, ON, Canada

[287] Lakeridge Hlth Oshawa, Oshawa, ON, Canada

[288] Ctr Sante & Serv Soc Reg Thetford Rech, Thetford Mines, PQ, Canada

[289] St Johns Hosp, St John, NB, Canada

[290] Laval Hosp, Quebec Heart Inst, Quebec City, PQ, Canada

[291] Rech GCP Res, Montreal, PQ, Canada

[292] Penticton Reg Hosp, Penticton, BC, Canada

[293] Montreal Gen Hosp, Montreal, PQ, Canada

[294] Queen Elizabeth 2 Hlth Sci Ctr, Halifax, NS, Canada

[295] Med Profess Corp, St Catharines, ON, Canada

[296] Ctr Invest Clin Cics, Temuco, Chile

[297] Corp Beneficencia Osorno, Osorno, Chile

[298] Hosp Clin Univ Chile, Santiago, Chile

[299] Ctr Invest Clin Univ, Santiago, Chile

[300] Hosp Barros Luco, Santiago, Chile

[301] Hosp Salvador, Santiago, Chile

[302] Hosp Naval Almirante Nef Vina Del Mar, Vina Del Mar, Chile

[303] Hosp Clin Magallanes, Punta Arenas, Chile

[304] Clin Alemana Santiago, Santiago, Chile

[305] Hosp Clin Reg Dr Guillermo Grant Benavente, Concepcion, Chile

[306] Psicomed Clin & Res Grp, Santiago, Chile

[307] Biomed Res Grp, Santiago, Chile

[308] Clin Univ Catol Maule, Talca, Chile

[309] Estudios Clin Region Ltda, Vina Del Mar, Chile

[310] Hosp & CRS El Pino, Santiago, Chile

[311] Hosp Base Valdivia, Valdivia, Chile

[312] Complejo Asistencial Dr Sotero Del Rio, Santiago, Chile

[313] Guangdong Gen Hosp, Guangzhou, Peoples R China

[314] Sun Yat Sen Univ, Affiliated Hosp 1, Guangzhou, Peoples R China

[315] Wenzhou Med Univ, Affiliated Hosp 1, Wenzhou, Peoples R China

[316] Siping Cent Peoples Hosp, Siping, Peoples R China

[317] Guangdong Med Univ, Affiliated Hosp, Zhanjiang, Peoples R China

[318] Tianjin Union Med Ctr, Tianjin, Peoples R China

[319] Yanbian Univ Hosp, Yanji, Peoples R China

[320] TEDA Int Cardiovasc Hosp, Tianjin, Peoples R China

[321] Tianjin Med Univ, Gen Hosp, Tianjin, Peoples R China

[322] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Guangzhou, Peoples R China

[323] Peking Univ, Hosp 1, Beijing, Peoples R China

[324] Peoples Hosp, Changchun, Peoples R China

[325] Xuzhou Med Coll, Affiliated Hosp, Xuzhou, Jiangsu, Peoples R China

[326] Guizhou Prov Peoples Hosp, Guiyang, Peoples R China

[327] Third Mil Med Univ, Xinqiao Hosp, Chongqing, Peoples R China

[328] Shenzhen Peoples Hosp, Shenzhen, Peoples R China

[329] Shandong Univ, Jinan Cent Hosp Affiliated, Jinan, Peoples R China

[330] NJMU, Nanjing Drum Tower Hosp, Affiliated Hosp, Nanjing, Peoples R China

[331] Wuhan Asian Heart Hosp, Wuhan, Peoples R China

[332] Nanchang Univ, Affiliated Hosp 2, Nanchang, Jiangxi, Peoples R China

[333] Fujian Med Univ, Affiliated Hosp 1, Fuzhou, Peoples R China

[334] Third Peoples Hosp Hubei Prov, Wuhan, Peoples R China

[335] Tianjin 4th Ctr Hosp, Tianjin, Peoples R China

[336] Southeast Univ, Zhongda Hosp, Nanjing, Peoples R China

[337] Southern Med Univ, Nanfang Hosp, Guangzhou, Peoples R China

[338] Beijing Chaoyang Hosp, Beijing, Peoples R China

[339] China Japan Friendship Hosp, Beijing, Peoples R China

[340] Baotou Med Coll, Affiliated Hosp 1, Baotou, Peoples R China

[341] Lanzhou Univ, Hosp 1, Lanzhou, Peoples R China

[342] Nanchang Univ, Affiliated Hosp 1, Nanchang, Jiangxi, Peoples R China

[343] Fuzhou Gen Hosp Nanjing Mil Command, Fuzhou, Peoples R China

[344] Chinese Peoples Liberat Army Gen Hosp, Beijing, Peoples R China

[345] China Aerosp Corp, Cent Hosp, Beijing, Peoples R China

[346] Jilin Univ, Hosp 1, Changchun, Peoples R China

[347] China Med Univ, Shengjing Hosp, Shenyang, Peoples R China

[348] Cent South Univ, Xiangya Hosp 2, Changsha, Peoples R China

[349] Shanghai East Hosp, Shanghai, Peoples R China

[350] Shanghai Sixth Peoples Hosp, Shanghai, Peoples R China

[351] Shanghai First Peoples Hosp, Shanghai, Peoples R China

[352] Zhejiang Hosp, Hangzhou, Peoples R China

[353] Zhejiang Prov Peoples Hosp, Hangzhou, Peoples R China

[354] Cent South Univ, Xiangya Hosp 3, Changsha, Peoples R China

[355] Capital Med Univ, Beijing Anzhen Hosp, Beijing, Peoples R China

[356] Inner Mongolia Peoples Hosp, Hohhot, Peoples R China

[357] Xi An Jiao Tong Univ, Affiliated Hosp 1, Xian, Peoples R China

[358] Hunan Prov Peoples Hosp, Changsha, Peoples R China

[359] First Peoples Hosp Yueyang, Yueyang, Peoples R China

[360] Capital Med Univ, Beijing Tongren Hosp, Beijing, Peoples R China

[361] Fudan Univ, Zhongshan Hosp, Shanghai, Peoples R China

[362] Zhejiang Univ, Sir Run Run Shaw Hosp, Hangzhou, Peoples R China

[363] Lanzhou Univ, Hosp 2, Lanzhou, Peoples R China

[364] Shanghai Jiao Tong Univ, Shanghai Chest Hosp, Shanghai, Peoples R China

[365] Shaanxi Prov Peoples Hosp, Xian, Peoples R China

[366] Soochow Univ, Affiliated Hosp 1, Suzhou, Peoples R China

[367] Zhejiang Univ, Affiliated Hosp 2, Hangzhou, Peoples R China

[368] China Med Univ, Hosp 1, Shenyang, Peoples R China

[369] Shandong Univ, Hosp 2, Jinan, Peoples R China

[370] Shanghai Jiao Tong Univ, Ruijin Hosp Affiliated, Shanghai, Peoples R China

[371] Zhejiang Univ, Affiliated Hosp 1, Hangzhou, Peoples R China

[372] Hangzhou First Peoples Hosp, Hangzhou, Peoples R China

[373] Luzhou Med Coll, Affiliated Hosp, Luzhou, Peoples R China

[374] Navy Gen Hosp, Ctr Cardiol, Beijing, Peoples R China

[375] Peking Univ, Shenzhen Hosp, Shenzhen, Peoples R China

[376] Ctr Med Ejercicio & Rehabil Cardiaca, Medellin, Colombia

[377] Fdn Cardiomet Eje Cafetero CEQUIN, Armenia, Colombia

[378] Hosp Santa Clara, Bogota, Colombia

[379] IPS Rodrigo Botero SAS, Medellin, Colombia

[380] Asociac IPS Med Internistas Caldas, Manizales, Colombia

[381] Clin Costa Itda, Barranquilla, Colombia

[382] Fdn Oftalmolog FOSCAL, Bucaramanga, Colombia

[383] Caja Compensac Familiar CAFAM, Bogota, Colombia

[384] Fdn Ctr Invest Biomed Riescard, Espinal, Colombia

[385] IPS Ctr Med Julian Coronel SA, Cali, Colombia

[386] IPS Ctr Cient Asistencial Jose Luis Quing, Barranquilla, Colombia

[387] Ctr Cardiovasc Colombiano, Valle 156073, Colombia

[388] Ctr Diagnost Cardiol LTDA, Cartagena, Colombia

[389] Ctr Cardiovasc Aristides Sotomayor Santa L, Cartagena, Colombia

[390] SIMEDICS IPS SAS, Bogota, Colombia

[391] Fdn Caribe Invest Biomed, Barranquilla, Colombia

[392] Clin Hosp Ctr Zagreb, Zagreb, Croatia

[393] Gen Hosp Varazdin, Varazhdin, Croatia

[394] Univ Hosp Ctr Zagreb, Zagreb, Croatia

[395] Univ Hosp Ctr, Sestre Milosrdnice, Zagreb, Croatia

[396] Gen Hosp Slavonski Brod, Slavonski Brod, Croatia

[397] Clin Hosp Sveti Duh, Zagreb, Croatia

[398] Thalassotherapia Opatija, Opatija, Croatia

[399] Clin Hosp Merkur, Zagreb, Croatia

[400] Special Hosp Med Rehab Krapinske Toplice, Krapinske Toplice, Croatia

[401] Clin Hosp Ctr, Sestre Milosrdnice, Zagreb, Croatia

[402] Clin Hosp Ctr Rijeka, Rijeka, Croatia

[403] Gen Hosp Dubrovnik, Dubrovnik, Croatia

[404] Clin Hosp Dubrava, Zagreb, Croatia

[405] FN Brno, Brno, Czech Republic

[406] Krajska Nemocnice Liberec As, Liberec, Czech Republic

[407] Fak Nemocnice Hradec Kralove, Hradec Kralove, Czech Republic

[408] Fak Nemocnice Motole, Prague, Czech Republic

[409] InterkardioML Sro, Interni Kardiol Ambulance, Marianske Lazne, Czech Republic

[410] Vseobecna Fak Nemocnice Praze, Prague, Czech Republic

[411] Nemocnice Pardubickeho Kraje As, Pardubice, Czech Republic

[412] Mestska Nemocnice Ostrava, Ostrava, Czech Republic

[413] Fak Nemocnice Plzen, Plzen, Czech Republic

[414] Ctr Pro Choroby Srdce Cev, Kromeriz, Czech Republic

[415] Krajska Nemocnice Tomase Bati As, Zlin, Czech Republic

[416] Inst Klin Expt Med, Prague, Czech Republic

[417] Oblastni Nemocnice Kladno As, Kladno, Czech Republic

[418] Thomayerova Nemocnice, Prague, Czech Republic

[419] Fak Nemocnice Kralovske Vinohrady, Prague, Czech Republic

[420] Kardio Sever Ro, Ceska Lipa, Czech Republic

[421] Kardiol Ambulance, Rakovnik, Czech Republic

[422] Nemocnice Na Homolce, Prague, Czech Republic

[423] Fak Nemocnice Olomouc, Olomouc, Czech Republic

关键词: acute coronary syndrome;    alirocumab;    cerebrovascular disease;    death;    major adverse cardiac events;    peripheral artery disease;   

DOI  :  10.1016/j.jacc.2019.03.013

来源: Elsevier

【 摘 要 】

BACKGROUND Patients with acute coronary syndrome (ACS) and concomitant noncoronary atherosclerosis have a high risk of major adverse cardiovascular events (MACEs) and death. The impact of lipid lowering by proprotein convertase subtilisin-kexin type 9 inhibition in such patients is undetermined. OBJECTIVES This pre-specified analysis from ODYSSEY OUTCOMES (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab) determined whether polyvascular disease influenced risks of MACEs and death and their modification by alirocumab in patients with recent ACS and dyslipidemia despite intensive statin therapy. METHODS Patients were randomized to alirocumab or placebo 1 to 12 months after ACS. The primary MACEs endpoint was the composite of coronary heart disease death, nonfatal myocardial infarction, fatal or nonfatal ischemic stroke, or unstable angina requiring hospitalization. All-cause death was a secondary endpoint. RESULTS Median follow-up was 2.8 years. Of 18,924 patients, 17,370 had monovascular (coronary) disease, 1,405 had polyvascular disease in 2 beds (coronary and peripheral artery or cerebrovascular), and 149 had polyvascular disease in 3 beds (coronary, peripheral artery, cerebrovascular). With placebo, the incidence of MACEs by respective vascular categories was 10.0%, 22.2%, and 39.7%. With alirocumab, the corresponding absolute risk reduction was 1.4% (95% confidence interval [CI]: 0.6% to 2.3%), 1.9% (95% CI: -2.4% to 6.2%), and 13.0% (95% CI: -2.0% to 28.0%). With placebo, the incidence of death by respective vascular categories was 3.5%, 10.0%, and 21.8%; the absolute risk reduction with alirocumab was 0.4% (95% CI: -0.1% to 1.0%), 1.3% (95% CI: -1.8% to 4.3%), and 16.2% (95% CI: 5.5% to 26.8%). CONCLUSIONS In patients with recent ACS and dyslipidemia despite intensive statin therapy, polyvascular disease is associated with high risks of MACEs and death. The large absolute reductions in those risks with alirocumab are a potential benefit for these patients. (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab [ODYSSEY OUTCOMES]: NCT01663402) (C) 2019 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.

【 授权许可】

Free