Effects of Statins on Memory, Cognition, and Brain Volume in the Elderly

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

卷:74

Article

Samaras, Katherine^1,2,3  Makkar, Steve R.⁴  Crawford, John D.⁴  Kochan, Nicole A.⁴  Slavin, Melissa J.⁴  Wen, Wei⁴  Trollor, Julian N.^4,5  Brodaty, Henry^4,6  Sachdev, Perminder S.^4,6,7 

[1] St Vincents Hosp, Dept Endocrinol, Sydney, NSW, Australia

[2] Garvan Inst Med Res, Diabet & Metab, Sydney, NSW, Australia

[3] Univ New South Wales Sydney, St Vincents Clin Sch, Sydney, NSW, Australia

[4] Univ New South Wales Sydney, Sch Psychiat, Ctr Hlth Brain Ageing, Sydney, NSW, Australia

[5] Univ New South Wales Sydney, Dept Dev Disabil Neuropsychiat, Sydney, NSW, Australia

[6] Univ New South Wales Sydney, Dementia Collaborat Res Ctr, Sydney, NSW, Australia

[7] Prince Wales Hosp, Neuropsychiat Inst, Euroa Ctr, Sydney, NSW, Australia

关键词: brain;    cognition;    dementia;    hydroxymethylglutaryl coenzyme A reductase inhibitors;    memory;    statins;   

DOI  :  10.1016/j.jacc.2019.09.041

来源: Elsevier

【 摘 要 】

BACKGROUND There is widespread consumer concern that statin use may be associated with impaired memory and cognitive decline. OBJECTIVES This study sought to examine the association between statin use and changes in memory and global cognition in the elderly population over 6 years and brain volumes over 2 years. Interactions between statin use and known dementia risk factors were examined. METHODS Prospective observational study of community-dwelling elderly Australians age 70 to 90 years (the MAS [Sydney Memory and Ageing Study], n = 1,037). Outcome measures were memory and global cognition (by neuropsychotogical testing every 2 years) and total brain, hippocampat and parahippocampat volumes (by magnetic resonance) in a subgroup (n = 526). Analyses applied linear mixed modeling, including the covariates of age, sex, education, body mass index, heart disease, diabetes, hypertension, stroke, smoking, and apotipoprotein E epsilon 4 carriage. Interactions were sought between statin use and dementia risk factors. RESULTS Over 6 years there was no difference in the rate of decline in memory or global cognition between statin users and never users. Statin initiation during the observation period was associated with blunting the rate of memory decline. Exploratory analyses found statin use was associated with attenuated decline in specific memory test performance in participants with heart disease and apotipoprotein E epsilon 4 carriage. There was no difference in brain volume changes between statin users and never users. CONCLUSIONS In community-dwelling elderly Australians, statin therapy was not associated with any greater decline in memory or cognition over 6 years. These data are reassuring for consumers concerned about statin use and risk of memory decline. Crown Copyright (C) 2019 Published by Elsevier on behalf of the American College of Cardiology Foundation. Mt rights reserved.

【 授权许可】

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