Relative Wall Thickness and the Risk for Ventricular Tachyarrhythmias in Patients With Left Ventricular Dysfunction

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

卷:67

Article

Biton, Yitschak^1,2  Goldenberg, Ilan^1,2  Kutyifa, Valentina¹  Baman, Jayson R.¹  Solomon, Scott⁴  Moss, Arthur J.¹  Szepietowska, Barbara¹  McNitt, Scott¹  Polonsky, Bronislava¹  Zareba, Wojciech¹  Barsheshet, Alon^1,5,3 

[1] Univ Rochester, Med Ctr, Heart Res Follow Up Program, Div Cardiol,Dept Med, Rochester, NY 14642 USA

[2] Sheba Med Ctr, Inst Heart, Ramat Gan, Israel

[3] Tel Aviv Univ, Sackler Sch Med, IL-69978 Tel Aviv, Israel

[4] Harvard Univ, Brigham & Womens Hosp, Sch Med, Boston, MA 02115 USA

[5] Rabin Med Ctr, Dept Cardiol, Petah Tiqwa, Israel

关键词: cardiac resynchronization therapy;    heart failure;    implantable cardioverter-defibrillator;    mortality;    ventricular fibrillation;    ventricular tachycardia;   

DOI  :  10.1016/j.jacc.2015.10.076

来源: Elsevier

【 摘 要 】

BACKGROUND Relative wall thickness (RWT), defined as 2 times posterior wall thickness divided by the left ventricular (LV) diastolic diameter, is a measure of LV geometry and may be a marker for adverse events in patients with LV dysfunction. OBJECTIVES The aim of this study was to investigate the relationship between RWT and the risk for ventricular tachyarrhythmia (VA) in patients enrolled in the MADIT-CRT (Multicenter Automatic Defibrillator Implantation Trial With Cardiac Resynchronization Therapy) study. METHODS The study population comprised 1,260 patients with mild heart failure and left bundle branch block. RESULTS In a multivariable model, RWT was the most powerful echocardiographic measure for estimating the risk of VAs compared with commonly used echocardiographic variables. Patients with low RWT (<0.24) had 83% (p < 0.001) increased risk for VA and 68% (p < 0.001) increase in VA risk or death (VA/death) compared with patients with higher RWT values. Each 0.01-unit decrease in RWT was associated with 12% (p < 0.001) and 10% (p < 0.001) increases in the risk of VA and VA/death, respectively. Treatment with cardiac resynchronization therapy with defibrillator (CRT-D; CRT with implantable cardioverter-defibrillator) was associated with a greater increase in RWT compared with implantable cardioverter-defibrillator at 12 months (4.6 +/- 6.8% vs. 1.5 +/- 2.7%; p < 0.001), and every 10% increase in RWT in CRT-D patients was associated with 34% (p = 0.027) and 36% (p = 0.009) reductions in the risk of subsequent VA and VA/death, respectively. CONCLUSIONS In patients with mild heart failure and left bundle branch block, decreased RWT was associated with an increase in the risk of VA and VA/death. CRT-D therapy was associated with a favorable increase in RWT and reduction in risk of VA and VA/death. (Multicenter Automatic Defibrillator Implantation Trial With Cardiac Resynchronization Therapy [MADIT-CRT]; NCT00180271) (C) 2016 by the American College of Cardiology Foundation.

【 授权许可】

Free