Cryoballoon Ablation as Initial Treatment for Atrial Fibrillation

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

卷:78

Review

Andrade, Jason G.^1,2,3  Wazni, Oussama M.⁴  Kuniss, Malte⁵  Hawkins, Nathaniel M.^1,2  Deyell, Marc W.^1,2  Chierchia, Gian-Battista^6,7  Nissen, Steven⁴  Verma, Atul⁸  Wells, George A.⁹  Turgeon, Ricky D.¹ 

[1] Univ British Columbia, Vancouver, BC, Canada

[2] Ctr Cardiovasc Innovat, Vancouver, BC, Canada

[3] Univ Montreal, Montreal Heart Inst, Montreal, PQ, Canada

[4] Cleveland Clin, Cleveland, OH USA

[5] Kerckhoff Klin, Bad Nauheim, Germany

[6] Univ Ziekenhuis Brussel, Brussels, Belgium

[7] Vrije Univ Brussel, Brussels, Belgium

[8] Univ Toronto, Southlake Reg Hlth Ctr, Newmarket, ON, Canada

[9] Univ Ottawa Heart Inst, Cardiovasc Res Methods Ctr, Ottawa, ON, Canada

关键词: ablation;    atrial fibrillation;    catheter ablation;    cryoballoon;    cryotherapy;    antiarrhythmic;   

DOI  :  10.1016/j.jacc.2021.06.038

来源: Elsevier

【 摘 要 】

Atrial fibrillation (AF), the most common sustained arrhythmia observed in clinical practice, is a chronic and progressive disorder characterized by exacerbations and remissions. Guidelines recommend antiarrhythmic drugs as the initial therapy for the maintenance of sinus rhythm; however, antiarrhythmic drugs have modest efficacy to maintain sinus rhythm and can be associated with significant adverse effects. An initial treatment strategy of cryoballoon catheter ablation in patients with treatment-naive AF has been shown to significantly improve arrhythmia outcomes (freedom from any, or symptomatic atrial tachyarrhythmia), produce clinically meaningful improvements in patient-reported outcomes (symptoms and quality of life), and significantly reduce subsequent health care resource use (hospitalization), and it does not increase the risk of serious or any adverse events compared with initial antiarrhythmic drug therapy. These findings are relevant to inform patients, providers, and health care systems regarding the initial choice of rhythm-control therapy in patients with treatment-naive AF. (J Am Coll Cardiol 2021;78:914-930) (c) 2021 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

【 授权许可】

Free